Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

Mechanism-based inhibitors of glycoside hydrolases are useful probes for basic research and represent potential drug candidates. Here, the authors present a series of mechanism-based covalent α-galactosidase inhibitors and elucidate the kinetic and structural basis of their inhibitory activity.

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Autores principales:	Weiwu Ren, Robert Pengelly, Marco Farren-Dai, Saeideh Shamsi Kazem Abadi, Verena Oehler, Oluwafemi Akintola, Jason Draper, Michael Meanwell, Saswati Chakladar, Katarzyna Świderek, Vicent Moliner, Robert Britton, Tracey M. Gloster, Andrew J. Bennet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/744697e101804594badef9eae41b0671
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spelling	oai:doaj.org-article:744697e101804594badef9eae41b06712021-12-02T14:40:02ZRevealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level10.1038/s41467-018-05702-72041-1723https://doaj.org/article/744697e101804594badef9eae41b06712018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05702-7https://doaj.org/toc/2041-1723Mechanism-based inhibitors of glycoside hydrolases are useful probes for basic research and represent potential drug candidates. Here, the authors present a series of mechanism-based covalent α-galactosidase inhibitors and elucidate the kinetic and structural basis of their inhibitory activity.Weiwu RenRobert PengellyMarco Farren-DaiSaeideh Shamsi Kazem AbadiVerena OehlerOluwafemi AkintolaJason DraperMichael MeanwellSaswati ChakladarKatarzyna ŚwiderekVicent MolinerRobert BrittonTracey M. GlosterAndrew J. BennetNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weiwu Ren Robert Pengelly Marco Farren-Dai Saeideh Shamsi Kazem Abadi Verena Oehler Oluwafemi Akintola Jason Draper Michael Meanwell Saswati Chakladar Katarzyna Świderek Vicent Moliner Robert Britton Tracey M. Gloster Andrew J. Bennet Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
description	Mechanism-based inhibitors of glycoside hydrolases are useful probes for basic research and represent potential drug candidates. Here, the authors present a series of mechanism-based covalent α-galactosidase inhibitors and elucidate the kinetic and structural basis of their inhibitory activity.
format	article
author	Weiwu Ren Robert Pengelly Marco Farren-Dai Saeideh Shamsi Kazem Abadi Verena Oehler Oluwafemi Akintola Jason Draper Michael Meanwell Saswati Chakladar Katarzyna Świderek Vicent Moliner Robert Britton Tracey M. Gloster Andrew J. Bennet
author_facet	Weiwu Ren Robert Pengelly Marco Farren-Dai Saeideh Shamsi Kazem Abadi Verena Oehler Oluwafemi Akintola Jason Draper Michael Meanwell Saswati Chakladar Katarzyna Świderek Vicent Moliner Robert Britton Tracey M. Gloster Andrew J. Bennet
author_sort	Weiwu Ren
title	Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
title_short	Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
title_full	Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
title_fullStr	Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
title_full_unstemmed	Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
title_sort	revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/744697e101804594badef9eae41b0671
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Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

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