14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
The cellular toxicity of Pseudomonas exotoxin-S and -T depends on their activation by 14-3-3 but the underlying molecular mechanism is not fully understood. Here, the authors show that a previously unrecognized 14-3-3:exotoxin binding interface is sufficient for complex formation and toxin activatio...
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Nature Portfolio
2018
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oai:doaj.org-article:744bcb86311e401b9b088850c4b2acfd2021-12-02T17:31:29Z14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface10.1038/s41467-018-06194-12041-1723https://doaj.org/article/744bcb86311e401b9b088850c4b2acfd2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06194-1https://doaj.org/toc/2041-1723The cellular toxicity of Pseudomonas exotoxin-S and -T depends on their activation by 14-3-3 but the underlying molecular mechanism is not fully understood. Here, the authors show that a previously unrecognized 14-3-3:exotoxin binding interface is sufficient for complex formation and toxin activation.Tobias KarlbergPeter HornyakAna Filipa PintoStefina MilanovaMahsa EbrahimiMikael LindbergNikolai PüllenAxel NordströmElinor LöverliRémi CaraballoEmily V. WongKatja NäreojaAnn-Gerd ThorsellMikael ElofssonEnrique M. De La CruzCamilla BjörkegrenHerwig SchülerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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Science Q Tobias Karlberg Peter Hornyak Ana Filipa Pinto Stefina Milanova Mahsa Ebrahimi Mikael Lindberg Nikolai Püllen Axel Nordström Elinor Löverli Rémi Caraballo Emily V. Wong Katja Näreoja Ann-Gerd Thorsell Mikael Elofsson Enrique M. De La Cruz Camilla Björkegren Herwig Schüler 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface |
description |
The cellular toxicity of Pseudomonas exotoxin-S and -T depends on their activation by 14-3-3 but the underlying molecular mechanism is not fully understood. Here, the authors show that a previously unrecognized 14-3-3:exotoxin binding interface is sufficient for complex formation and toxin activation. |
format |
article |
author |
Tobias Karlberg Peter Hornyak Ana Filipa Pinto Stefina Milanova Mahsa Ebrahimi Mikael Lindberg Nikolai Püllen Axel Nordström Elinor Löverli Rémi Caraballo Emily V. Wong Katja Näreoja Ann-Gerd Thorsell Mikael Elofsson Enrique M. De La Cruz Camilla Björkegren Herwig Schüler |
author_facet |
Tobias Karlberg Peter Hornyak Ana Filipa Pinto Stefina Milanova Mahsa Ebrahimi Mikael Lindberg Nikolai Püllen Axel Nordström Elinor Löverli Rémi Caraballo Emily V. Wong Katja Näreoja Ann-Gerd Thorsell Mikael Elofsson Enrique M. De La Cruz Camilla Björkegren Herwig Schüler |
author_sort |
Tobias Karlberg |
title |
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface |
title_short |
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface |
title_full |
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface |
title_fullStr |
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface |
title_full_unstemmed |
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface |
title_sort |
14-3-3 proteins activate pseudomonas exotoxins-s and -t by chaperoning a hydrophobic surface |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/744bcb86311e401b9b088850c4b2acfd |
work_keys_str_mv |
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