14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

The cellular toxicity of Pseudomonas exotoxin-S and -T depends on their activation by 14-3-3 but the underlying molecular mechanism is not fully understood. Here, the authors show that a previously unrecognized 14-3-3:exotoxin binding interface is sufficient for complex formation and toxin activatio...

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Autores principales: Tobias Karlberg, Peter Hornyak, Ana Filipa Pinto, Stefina Milanova, Mahsa Ebrahimi, Mikael Lindberg, Nikolai Püllen, Axel Nordström, Elinor Löverli, Rémi Caraballo, Emily V. Wong, Katja Näreoja, Ann-Gerd Thorsell, Mikael Elofsson, Enrique M. De La Cruz, Camilla Björkegren, Herwig Schüler
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Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/744bcb86311e401b9b088850c4b2acfd
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spelling oai:doaj.org-article:744bcb86311e401b9b088850c4b2acfd2021-12-02T17:31:29Z14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface10.1038/s41467-018-06194-12041-1723https://doaj.org/article/744bcb86311e401b9b088850c4b2acfd2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06194-1https://doaj.org/toc/2041-1723The cellular toxicity of Pseudomonas exotoxin-S and -T depends on their activation by 14-3-3 but the underlying molecular mechanism is not fully understood. Here, the authors show that a previously unrecognized 14-3-3:exotoxin binding interface is sufficient for complex formation and toxin activation.Tobias KarlbergPeter HornyakAna Filipa PintoStefina MilanovaMahsa EbrahimiMikael LindbergNikolai PüllenAxel NordströmElinor LöverliRémi CaraballoEmily V. WongKatja NäreojaAnn-Gerd ThorsellMikael ElofssonEnrique M. De La CruzCamilla BjörkegrenHerwig SchülerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tobias Karlberg
Peter Hornyak
Ana Filipa Pinto
Stefina Milanova
Mahsa Ebrahimi
Mikael Lindberg
Nikolai Püllen
Axel Nordström
Elinor Löverli
Rémi Caraballo
Emily V. Wong
Katja Näreoja
Ann-Gerd Thorsell
Mikael Elofsson
Enrique M. De La Cruz
Camilla Björkegren
Herwig Schüler
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
description The cellular toxicity of Pseudomonas exotoxin-S and -T depends on their activation by 14-3-3 but the underlying molecular mechanism is not fully understood. Here, the authors show that a previously unrecognized 14-3-3:exotoxin binding interface is sufficient for complex formation and toxin activation.
format article
author Tobias Karlberg
Peter Hornyak
Ana Filipa Pinto
Stefina Milanova
Mahsa Ebrahimi
Mikael Lindberg
Nikolai Püllen
Axel Nordström
Elinor Löverli
Rémi Caraballo
Emily V. Wong
Katja Näreoja
Ann-Gerd Thorsell
Mikael Elofsson
Enrique M. De La Cruz
Camilla Björkegren
Herwig Schüler
author_facet Tobias Karlberg
Peter Hornyak
Ana Filipa Pinto
Stefina Milanova
Mahsa Ebrahimi
Mikael Lindberg
Nikolai Püllen
Axel Nordström
Elinor Löverli
Rémi Caraballo
Emily V. Wong
Katja Näreoja
Ann-Gerd Thorsell
Mikael Elofsson
Enrique M. De La Cruz
Camilla Björkegren
Herwig Schüler
author_sort Tobias Karlberg
title 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
title_short 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
title_full 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
title_fullStr 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
title_full_unstemmed 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
title_sort 14-3-3 proteins activate pseudomonas exotoxins-s and -t by chaperoning a hydrophobic surface
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/744bcb86311e401b9b088850c4b2acfd
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