A krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats.
Krill oil (KO) is a dietary source of n-3 polyunsaturated fatty acids, mainly represented by eicosapentaenoic acid and docosahexaenoic acid bound to phospholipids. The supplementation of a high-fat diet with 2.5% KO efficiently prevented triglyceride and cholesterol accumulation in liver of treated...
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2012
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oai:doaj.org-article:744f4eea5c3249f8b901285ace20cf3b2021-11-18T07:16:00ZA krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats.1932-620310.1371/journal.pone.0038797https://doaj.org/article/744f4eea5c3249f8b901285ace20cf3b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22685607/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Krill oil (KO) is a dietary source of n-3 polyunsaturated fatty acids, mainly represented by eicosapentaenoic acid and docosahexaenoic acid bound to phospholipids. The supplementation of a high-fat diet with 2.5% KO efficiently prevented triglyceride and cholesterol accumulation in liver of treated rats. This effect was accompanied by a parallel reduction of the plasma levels of triglycerides and glucose and by the prevention of a plasma insulin increase. The investigation of the molecular mechanisms of KO action in high-fat fed animals revealed a strong decrease in the activities of the mitochondrial citrate carrier and of the cytosolic acetyl-CoA carboxylase and fatty acid synthetase, which are both involved in hepatic de novo lipogenesis. In these animals a significant increase in the activity of carnitine palmitoyl-transferase I and in the levels of carnitine was also observed, suggesting a concomitant stimulation of hepatic fatty acid oxidation. The KO supplemented animals also retained an efficient mitochondrial oxidative phosphorylation, most probably as a consequence of a KO-induced arrest of the uncoupling effects of a high-fat diet. Lastly, the KO supplementation prevented an increase in body weight, as well as oxidative damage of lipids and proteins, which is often found in high-fat fed animals.Alessandra FerramoscaAnnalea ConteLena BurriKjetil BergeFrancesco De NuccioAnna Maria GiudettiVincenzo ZaraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e38797 (2012) |
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Medicine R Science Q |
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Medicine R Science Q Alessandra Ferramosca Annalea Conte Lena Burri Kjetil Berge Francesco De Nuccio Anna Maria Giudetti Vincenzo Zara A krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats. |
| description |
Krill oil (KO) is a dietary source of n-3 polyunsaturated fatty acids, mainly represented by eicosapentaenoic acid and docosahexaenoic acid bound to phospholipids. The supplementation of a high-fat diet with 2.5% KO efficiently prevented triglyceride and cholesterol accumulation in liver of treated rats. This effect was accompanied by a parallel reduction of the plasma levels of triglycerides and glucose and by the prevention of a plasma insulin increase. The investigation of the molecular mechanisms of KO action in high-fat fed animals revealed a strong decrease in the activities of the mitochondrial citrate carrier and of the cytosolic acetyl-CoA carboxylase and fatty acid synthetase, which are both involved in hepatic de novo lipogenesis. In these animals a significant increase in the activity of carnitine palmitoyl-transferase I and in the levels of carnitine was also observed, suggesting a concomitant stimulation of hepatic fatty acid oxidation. The KO supplemented animals also retained an efficient mitochondrial oxidative phosphorylation, most probably as a consequence of a KO-induced arrest of the uncoupling effects of a high-fat diet. Lastly, the KO supplementation prevented an increase in body weight, as well as oxidative damage of lipids and proteins, which is often found in high-fat fed animals. |
| format |
article |
| author |
Alessandra Ferramosca Annalea Conte Lena Burri Kjetil Berge Francesco De Nuccio Anna Maria Giudetti Vincenzo Zara |
| author_facet |
Alessandra Ferramosca Annalea Conte Lena Burri Kjetil Berge Francesco De Nuccio Anna Maria Giudetti Vincenzo Zara |
| author_sort |
Alessandra Ferramosca |
| title |
A krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats. |
| title_short |
A krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats. |
| title_full |
A krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats. |
| title_fullStr |
A krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats. |
| title_full_unstemmed |
A krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats. |
| title_sort |
krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/744f4eea5c3249f8b901285ace20cf3b |
| work_keys_str_mv |
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1718423733457125376 |