Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats

Abstract. Sahraoui H, Madani T, Fantazi K, Chaouch Khouane A, Ameur Ameur A, Paschino P, Vacca GM, Gaouar SBS, Dettori ML. 2020. Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats. Biodiversitas 21...

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Autores principales:	Hossem SAHRAOUI, TOUFIK MADANI, KHALED FANTAZI, ASMA CHAOUCH KHOUANE, ABDELKADER AMEUR AMEUR, PIETRO PASCHINO, GIUSEPPE MASSIMO VACCA, SEMIR BECHIR SUHEIL GAOUAR, MARIA LUISA DETTORI
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2020
Materias:	brucellosis, disease innate resistance, genetic selection, polymorphism, native goat breeds, slc11a1 gene Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7453ec72e0fd473085cf8449e8b87617
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spelling	oai:doaj.org-article:7453ec72e0fd473085cf8449e8b876172021-11-22T00:52:01ZGenetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats1412-033X2085-472210.13057/biodiv/d211219https://doaj.org/article/7453ec72e0fd473085cf8449e8b876172020-11-01T00:00:00Zhttps://smujo.id/biodiv/article/view/6934https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Sahraoui H, Madani T, Fantazi K, Chaouch Khouane A, Ameur Ameur A, Paschino P, Vacca GM, Gaouar SBS, Dettori ML. 2020. Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats. Biodiversitas 21: 5630-5636. Goat rearing is among the major agricultural activities practiced in Algeria. However, brucellosis represents an important threat to the goat sector and to public health. The aim of our work was to characterize the genetic variability of the A microsatellite at the 3' untranslated region (3' UTR) of SLC11A1 gene in Algerian native goat breeds as it was associated with Brucellosis genetic resistance in goat. Genomic DNA samples of 90 goats belonging to the four Algerian native breeds; Mekatia (n = 32), Arbia (n = 30), Dwarf of Kabylia (n = 14) and Mozabit (n = 14) have been analyzed. Polymorphism of region A microsatellite was determined by capillary electrophoresis identifying 8 alleles and 20 genotypes. Genetic parameters were also estimated. Polymorphic information content was PIC = 0.60, the observed and the expected heterozygosity were Ho = 0.569 and He = 0.595, respectively, and the values of FIS, FIT and FST were 0.044, 0.064, and 0.021, respectively. The A microsatellite was highly polymorphic and alleles associated genetic resistance against brucellosis in other breeds or species have been identified. These results open a promising opportunity to implement a genetic improvement program to reduce goat brucellosis spread in Algeria.Hossem SAHRAOUITOUFIK MADANIKHALED FANTAZIASMA CHAOUCH KHOUANEABDELKADER AMEUR AMEURPIETRO PASCHINOGIUSEPPE MASSIMO VACCASEMIR BECHIR SUHEIL GAOUARMARIA LUISA DETTORIMBI & UNS Soloarticlebrucellosis, disease innate resistance, genetic selection, polymorphism, native goat breeds, slc11a1 geneBiology (General)QH301-705.5ENBiodiversitas, Vol 21, Iss 12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	brucellosis, disease innate resistance, genetic selection, polymorphism, native goat breeds, slc11a1 gene Biology (General) QH301-705.5
spellingShingle	brucellosis, disease innate resistance, genetic selection, polymorphism, native goat breeds, slc11a1 gene Biology (General) QH301-705.5 Hossem SAHRAOUI TOUFIK MADANI KHALED FANTAZI ASMA CHAOUCH KHOUANE ABDELKADER AMEUR AMEUR PIETRO PASCHINO GIUSEPPE MASSIMO VACCA SEMIR BECHIR SUHEIL GAOUAR MARIA LUISA DETTORI Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats
description	Abstract. Sahraoui H, Madani T, Fantazi K, Chaouch Khouane A, Ameur Ameur A, Paschino P, Vacca GM, Gaouar SBS, Dettori ML. 2020. Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats. Biodiversitas 21: 5630-5636. Goat rearing is among the major agricultural activities practiced in Algeria. However, brucellosis represents an important threat to the goat sector and to public health. The aim of our work was to characterize the genetic variability of the A microsatellite at the 3' untranslated region (3' UTR) of SLC11A1 gene in Algerian native goat breeds as it was associated with Brucellosis genetic resistance in goat. Genomic DNA samples of 90 goats belonging to the four Algerian native breeds; Mekatia (n = 32), Arbia (n = 30), Dwarf of Kabylia (n = 14) and Mozabit (n = 14) have been analyzed. Polymorphism of region A microsatellite was determined by capillary electrophoresis identifying 8 alleles and 20 genotypes. Genetic parameters were also estimated. Polymorphic information content was PIC = 0.60, the observed and the expected heterozygosity were Ho = 0.569 and He = 0.595, respectively, and the values of FIS, FIT and FST were 0.044, 0.064, and 0.021, respectively. The A microsatellite was highly polymorphic and alleles associated genetic resistance against brucellosis in other breeds or species have been identified. These results open a promising opportunity to implement a genetic improvement program to reduce goat brucellosis spread in Algeria.
format	article
author	Hossem SAHRAOUI TOUFIK MADANI KHALED FANTAZI ASMA CHAOUCH KHOUANE ABDELKADER AMEUR AMEUR PIETRO PASCHINO GIUSEPPE MASSIMO VACCA SEMIR BECHIR SUHEIL GAOUAR MARIA LUISA DETTORI
author_facet	Hossem SAHRAOUI TOUFIK MADANI KHALED FANTAZI ASMA CHAOUCH KHOUANE ABDELKADER AMEUR AMEUR PIETRO PASCHINO GIUSEPPE MASSIMO VACCA SEMIR BECHIR SUHEIL GAOUAR MARIA LUISA DETTORI
author_sort	Hossem SAHRAOUI
title	Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats
title_short	Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats
title_full	Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats
title_fullStr	Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats
title_full_unstemmed	Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats
title_sort	genetic variability in the a microsatellite at slc11a1 gene and possible implications with innate resistance against brucellosis in algerian native goats
publisher	MBI & UNS Solo
publishDate	2020
url	https://doaj.org/article/7453ec72e0fd473085cf8449e8b87617
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Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats

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