Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

Atherosclerosis is caused by low-density lipoprotein (LDL) buildup in the vessel wall, a process thought to be mediated by LDL receptor alone. Here, the authors show that the endothelium can uptake LDL via ALK1, a TGFβ signalling receptor, suggesting new therapies for blocking LDL accumulation in th...

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Autores principales:	Jan R. Kraehling, John H. Chidlow, Chitra Rajagopal, Michael G. Sugiyama, Joseph W. Fowler, Monica Y. Lee, Xinbo Zhang, Cristina M. Ramírez, Eon Joo Park, Bo Tao, Keyang Chen, Leena Kuruvilla, Bruno Larriveé, Ewa Folta-Stogniew, Roxana Ola, Noemi Rotllan, Wenping Zhou, Michael W. Nagle, Joachim Herz, Kevin Jon Williams, Anne Eichmann, Warren L. Lee, Carlos Fernández-Hernando, William C. Sessa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/745c383654124c2b97ea3d105429cf8d
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spelling	oai:doaj.org-article:745c383654124c2b97ea3d105429cf8d2021-12-02T14:38:33ZGenome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells10.1038/ncomms135162041-1723https://doaj.org/article/745c383654124c2b97ea3d105429cf8d2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13516https://doaj.org/toc/2041-1723Atherosclerosis is caused by low-density lipoprotein (LDL) buildup in the vessel wall, a process thought to be mediated by LDL receptor alone. Here, the authors show that the endothelium can uptake LDL via ALK1, a TGFβ signalling receptor, suggesting new therapies for blocking LDL accumulation in the vessel wall.Jan R. KraehlingJohn H. ChidlowChitra RajagopalMichael G. SugiyamaJoseph W. FowlerMonica Y. LeeXinbo ZhangCristina M. RamírezEon Joo ParkBo TaoKeyang ChenLeena KuruvillaBruno LarriveéEwa Folta-StogniewRoxana OlaNoemi RotllanWenping ZhouMichael W. NagleJoachim HerzKevin Jon WilliamsAnne EichmannWarren L. LeeCarlos Fernández-HernandoWilliam C. SessaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jan R. Kraehling John H. Chidlow Chitra Rajagopal Michael G. Sugiyama Joseph W. Fowler Monica Y. Lee Xinbo Zhang Cristina M. Ramírez Eon Joo Park Bo Tao Keyang Chen Leena Kuruvilla Bruno Larriveé Ewa Folta-Stogniew Roxana Ola Noemi Rotllan Wenping Zhou Michael W. Nagle Joachim Herz Kevin Jon Williams Anne Eichmann Warren L. Lee Carlos Fernández-Hernando William C. Sessa Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
description	Atherosclerosis is caused by low-density lipoprotein (LDL) buildup in the vessel wall, a process thought to be mediated by LDL receptor alone. Here, the authors show that the endothelium can uptake LDL via ALK1, a TGFβ signalling receptor, suggesting new therapies for blocking LDL accumulation in the vessel wall.
format	article
author	Jan R. Kraehling John H. Chidlow Chitra Rajagopal Michael G. Sugiyama Joseph W. Fowler Monica Y. Lee Xinbo Zhang Cristina M. Ramírez Eon Joo Park Bo Tao Keyang Chen Leena Kuruvilla Bruno Larriveé Ewa Folta-Stogniew Roxana Ola Noemi Rotllan Wenping Zhou Michael W. Nagle Joachim Herz Kevin Jon Williams Anne Eichmann Warren L. Lee Carlos Fernández-Hernando William C. Sessa
author_facet	Jan R. Kraehling John H. Chidlow Chitra Rajagopal Michael G. Sugiyama Joseph W. Fowler Monica Y. Lee Xinbo Zhang Cristina M. Ramírez Eon Joo Park Bo Tao Keyang Chen Leena Kuruvilla Bruno Larriveé Ewa Folta-Stogniew Roxana Ola Noemi Rotllan Wenping Zhou Michael W. Nagle Joachim Herz Kevin Jon Williams Anne Eichmann Warren L. Lee Carlos Fernández-Hernando William C. Sessa
author_sort	Jan R. Kraehling
title	Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
title_short	Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
title_full	Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
title_fullStr	Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
title_full_unstemmed	Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
title_sort	genome-wide rnai screen reveals alk1 mediates ldl uptake and transcytosis in endothelial cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/745c383654124c2b97ea3d105429cf8d
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Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

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