Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells

In secondary lymphoid organs T follicular helper (Tfh) cells help B cells to develop into memory B and plasma cells. Here, the authors show that inflamed lung becomes a reservoir of activated B cells with a germinal centre phenotype, and T cells that exhibit Tfh-like properties despite not expressin...

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Autores principales: Dana Vu Van, Katja C. Beier, Lea-Jean Pietzke, Maysun S. Al Baz, Randi K. Feist, Stephanie Gurka, Eckard Hamelmann, Richard A. Kroczek, Andreas Hutloff
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/745dc794203e438ea935aca0e77d92d9
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Sumario:In secondary lymphoid organs T follicular helper (Tfh) cells help B cells to develop into memory B and plasma cells. Here, the authors show that inflamed lung becomes a reservoir of activated B cells with a germinal centre phenotype, and T cells that exhibit Tfh-like properties despite not expressing classical Tfh markers.