Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

The differentiation and function of regulatory T (Treg) cells are critically controlled by T cell receptor (TCR) signaling. Here the authors show that CARD11-BCL10-MALT1 (CBM) complexes are dispensable for effector Treg conversion under inflammatory conditions but are critical for mediating Treg sup...

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Autores principales:	Marc Rosenbaum, Andreas Gewies, Konstanze Pechloff, Christoph Heuser, Thomas Engleitner, Torben Gehring, Lara Hartjes, Sabrina Krebs, Daniel Krappmann, Mark Kriegsmann, Wilko Weichert, Roland Rad, Christian Kurts, Jürgen Ruland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/745f4f6f20b44529be4f9c3e0da19c9e
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spelling	oai:doaj.org-article:745f4f6f20b44529be4f9c3e0da19c9e2021-12-02T14:39:59ZBcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells10.1038/s41467-019-10203-22041-1723https://doaj.org/article/745f4f6f20b44529be4f9c3e0da19c9e2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10203-2https://doaj.org/toc/2041-1723The differentiation and function of regulatory T (Treg) cells are critically controlled by T cell receptor (TCR) signaling. Here the authors show that CARD11-BCL10-MALT1 (CBM) complexes are dispensable for effector Treg conversion under inflammatory conditions but are critical for mediating Treg suppressive activity in a MALT1 paracaspase-dependent manner.Marc RosenbaumAndreas GewiesKonstanze PechloffChristoph HeuserThomas EngleitnerTorben GehringLara HartjesSabrina KrebsDaniel KrappmannMark KriegsmannWilko WeichertRoland RadChristian KurtsJürgen RulandNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marc Rosenbaum Andreas Gewies Konstanze Pechloff Christoph Heuser Thomas Engleitner Torben Gehring Lara Hartjes Sabrina Krebs Daniel Krappmann Mark Kriegsmann Wilko Weichert Roland Rad Christian Kurts Jürgen Ruland Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
description	The differentiation and function of regulatory T (Treg) cells are critically controlled by T cell receptor (TCR) signaling. Here the authors show that CARD11-BCL10-MALT1 (CBM) complexes are dispensable for effector Treg conversion under inflammatory conditions but are critical for mediating Treg suppressive activity in a MALT1 paracaspase-dependent manner.
format	article
author	Marc Rosenbaum Andreas Gewies Konstanze Pechloff Christoph Heuser Thomas Engleitner Torben Gehring Lara Hartjes Sabrina Krebs Daniel Krappmann Mark Kriegsmann Wilko Weichert Roland Rad Christian Kurts Jürgen Ruland
author_facet	Marc Rosenbaum Andreas Gewies Konstanze Pechloff Christoph Heuser Thomas Engleitner Torben Gehring Lara Hartjes Sabrina Krebs Daniel Krappmann Mark Kriegsmann Wilko Weichert Roland Rad Christian Kurts Jürgen Ruland
author_sort	Marc Rosenbaum
title	Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
title_short	Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
title_full	Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
title_fullStr	Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
title_full_unstemmed	Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
title_sort	bcl10-controlled malt1 paracaspase activity is key for the immune suppressive function of regulatory t cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/745f4f6f20b44529be4f9c3e0da19c9e
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Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

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