Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

The differentiation and function of regulatory T (Treg) cells are critically controlled by T cell receptor (TCR) signaling. Here the authors show that CARD11-BCL10-MALT1 (CBM) complexes are dispensable for effector Treg conversion under inflammatory conditions but are critical for mediating Treg sup...

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Autores principales: Marc Rosenbaum, Andreas Gewies, Konstanze Pechloff, Christoph Heuser, Thomas Engleitner, Torben Gehring, Lara Hartjes, Sabrina Krebs, Daniel Krappmann, Mark Kriegsmann, Wilko Weichert, Roland Rad, Christian Kurts, Jürgen Ruland
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/745f4f6f20b44529be4f9c3e0da19c9e
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