Repurposing type I–F CRISPR–Cas system as a transcriptional activation tool in human cells

Class 1 type I CRISPR–Cas systems have not been as extensively developed for genome engineering as Class 2 systems. Here the authors modify the Type I–F CRISPR–Cas system for transcriptional activation of gene expression.

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Bibliographic Details
Main Authors: Yuxi Chen, Jiaqi Liu, Shengyao Zhi, Qi Zheng, Wenbin Ma, Junjiu Huang, Yizhi Liu, Dan Liu, Puping Liang, Zhou Songyang
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
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Online Access:https://doaj.org/article/745fca160c3f4701a3aaa2ef13877121
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