Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study

Yuka Kudo,1,2 Atsuo Nakagawa,1,3 Taisei Wake,1 Natsumi Ishikawa,1 Chika Kurata,1 Mizuki Nakahara,4 Teruo Nojima,2 Masaru Mimura1 1Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 2Department of Psychiatry, Gunma Hospital, Gunma, 3Clinical and Translational Research Center,...

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Autores principales:	Kudo Y, Nakagawa A, Wake T, Ishikawa N, Kurata C, Nakahara M, Nojima T, Mimura M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Temperament and Personality Questionnaire major depression prospective study remission Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/74606924c4ef447caa97bce0c3a9f5fa
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spelling	oai:doaj.org-article:74606924c4ef447caa97bce0c3a9f5fa2021-12-02T02:57:31ZTemperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study1178-2021https://doaj.org/article/74606924c4ef447caa97bce0c3a9f5fa2016-12-01T00:00:00Zhttps://www.dovepress.com/temperament-personality-and-treatment-outcome-in-major-depression-a-6--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yuka Kudo,1,2 Atsuo Nakagawa,1,3 Taisei Wake,1 Natsumi Ishikawa,1 Chika Kurata,1 Mizuki Nakahara,4 Teruo Nojima,2 Masaru Mimura1 1Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 2Department of Psychiatry, Gunma Hospital, Gunma, 3Clinical and Translational Research Center, Keio University School of Medicine, Tokyo, 4Graduate School, Tokyo University of Social Welfare, Gunma, Japan Background: Despite available treatments, major depression is a highly heterogeneous disorder, which leads to problems in classification and treatment specificity. Previous studies have reported that personality traits predict and influence the course and treatment response of depression. The Temperament and Personality Questionnaire (T&P) assesses eight major constructs of personality traits observed in those who develop depression. The aim of this study was to investigate the influence of T&P’s eight constructs on the treatment outcome of depressed patients.Patients and methods: A preliminary 6-month prospective study was conducted with a sample of 51 adult patients with a diagnosis of major depressive disorder (MDD) without remarkable psychomotor disturbance using the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. All patients received comprehensive assessment including the T&P at baseline. We compared each T&P construct score between patients who achieved remission and those who did not achieve remission after 6 months of treatment for depression using both subjective and objective measures. All 51 (100%) patients received the 6-month follow-up assessment.Results: This study demonstrated that higher scores on T&P personal reserve predicted poorer treatment outcome in patients with MDD. Higher levels of personal reserve, rejection sensitivity, and self-criticism correlated with higher levels of depression. Higher levels of rejection sensitivity and self-criticism were associated with non-remitters; however, when we controlled for baseline depression severity, this relationship did not show significance.Conclusion: Although the results are preliminary, this study suggests that high scores on T&P personal reserve predict poorer treatment outcome and T&P rejection sensitivity and self-criticism correlate with the severity of depression. Longer follow-up studies with large sample sizes are required to improve the understanding of these relationships. Keywords: Temperament and Personality Questionnaire, classification, treatment outcome, personal reserve, self-criticism, rejection sensitivityKudo YNakagawa AWake TIshikawa NKurata CNakahara MNojima TMimura MDove Medical PressarticleTemperament and Personality Questionnairemajor depressionprospective studyremissionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 17-24 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Temperament and Personality Questionnaire major depression prospective study remission Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Temperament and Personality Questionnaire major depression prospective study remission Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kudo Y Nakagawa A Wake T Ishikawa N Kurata C Nakahara M Nojima T Mimura M Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
description	Yuka Kudo,1,2 Atsuo Nakagawa,1,3 Taisei Wake,1 Natsumi Ishikawa,1 Chika Kurata,1 Mizuki Nakahara,4 Teruo Nojima,2 Masaru Mimura1 1Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 2Department of Psychiatry, Gunma Hospital, Gunma, 3Clinical and Translational Research Center, Keio University School of Medicine, Tokyo, 4Graduate School, Tokyo University of Social Welfare, Gunma, Japan Background: Despite available treatments, major depression is a highly heterogeneous disorder, which leads to problems in classification and treatment specificity. Previous studies have reported that personality traits predict and influence the course and treatment response of depression. The Temperament and Personality Questionnaire (T&P) assesses eight major constructs of personality traits observed in those who develop depression. The aim of this study was to investigate the influence of T&P’s eight constructs on the treatment outcome of depressed patients.Patients and methods: A preliminary 6-month prospective study was conducted with a sample of 51 adult patients with a diagnosis of major depressive disorder (MDD) without remarkable psychomotor disturbance using the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. All patients received comprehensive assessment including the T&P at baseline. We compared each T&P construct score between patients who achieved remission and those who did not achieve remission after 6 months of treatment for depression using both subjective and objective measures. All 51 (100%) patients received the 6-month follow-up assessment.Results: This study demonstrated that higher scores on T&P personal reserve predicted poorer treatment outcome in patients with MDD. Higher levels of personal reserve, rejection sensitivity, and self-criticism correlated with higher levels of depression. Higher levels of rejection sensitivity and self-criticism were associated with non-remitters; however, when we controlled for baseline depression severity, this relationship did not show significance.Conclusion: Although the results are preliminary, this study suggests that high scores on T&P personal reserve predict poorer treatment outcome and T&P rejection sensitivity and self-criticism correlate with the severity of depression. Longer follow-up studies with large sample sizes are required to improve the understanding of these relationships. Keywords: Temperament and Personality Questionnaire, classification, treatment outcome, personal reserve, self-criticism, rejection sensitivity
format	article
author	Kudo Y Nakagawa A Wake T Ishikawa N Kurata C Nakahara M Nojima T Mimura M
author_facet	Kudo Y Nakagawa A Wake T Ishikawa N Kurata C Nakahara M Nojima T Mimura M
author_sort	Kudo Y
title	Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
title_short	Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
title_full	Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
title_fullStr	Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
title_full_unstemmed	Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
title_sort	temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/74606924c4ef447caa97bce0c3a9f5fa
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Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study

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