Dinosaur peptides suggest mechanisms of protein survival.

Eleven collagen peptide sequences recovered from chemical extracts of dinosaur bones were mapped onto molecular models of the vertebrate collagen fibril derived from extant taxa. The dinosaur peptides localized to fibril regions protected by the close packing of collagen molecules, and contained few...

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Autores principales:	James D San Antonio, Mary H Schweitzer, Shane T Jensen, Raghu Kalluri, Michael Buckley, Joseph P R O Orgel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74608424e5534a7d8f329ffdb7b4f4ad
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id	oai:doaj.org-article:74608424e5534a7d8f329ffdb7b4f4ad
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spelling	oai:doaj.org-article:74608424e5534a7d8f329ffdb7b4f4ad2021-11-18T06:52:26ZDinosaur peptides suggest mechanisms of protein survival.1932-620310.1371/journal.pone.0020381https://doaj.org/article/74608424e5534a7d8f329ffdb7b4f4ad2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21687667/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Eleven collagen peptide sequences recovered from chemical extracts of dinosaur bones were mapped onto molecular models of the vertebrate collagen fibril derived from extant taxa. The dinosaur peptides localized to fibril regions protected by the close packing of collagen molecules, and contained few acidic amino acids. Four peptides mapped to collagen regions crucial for cell-collagen interactions and tissue development. Dinosaur peptides were not represented in more exposed parts of the collagen fibril or regions mediating intermolecular cross-linking. Thus functionally significant regions of collagen fibrils that are physically shielded within the fibril may be preferentially preserved in fossils. These results show empirically that structure-function relationships at the molecular level could contribute to selective preservation in fossilized vertebrate remains across geological time, suggest a 'preservation motif', and bolster current concepts linking collagen structure to biological function. This non-random distribution supports the hypothesis that the peptides are produced by the extinct organisms and suggests a chemical mechanism for survival.James D San AntonioMary H SchweitzerShane T JensenRaghu KalluriMichael BuckleyJoseph P R O OrgelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20381 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q James D San Antonio Mary H Schweitzer Shane T Jensen Raghu Kalluri Michael Buckley Joseph P R O Orgel Dinosaur peptides suggest mechanisms of protein survival.
description	Eleven collagen peptide sequences recovered from chemical extracts of dinosaur bones were mapped onto molecular models of the vertebrate collagen fibril derived from extant taxa. The dinosaur peptides localized to fibril regions protected by the close packing of collagen molecules, and contained few acidic amino acids. Four peptides mapped to collagen regions crucial for cell-collagen interactions and tissue development. Dinosaur peptides were not represented in more exposed parts of the collagen fibril or regions mediating intermolecular cross-linking. Thus functionally significant regions of collagen fibrils that are physically shielded within the fibril may be preferentially preserved in fossils. These results show empirically that structure-function relationships at the molecular level could contribute to selective preservation in fossilized vertebrate remains across geological time, suggest a 'preservation motif', and bolster current concepts linking collagen structure to biological function. This non-random distribution supports the hypothesis that the peptides are produced by the extinct organisms and suggests a chemical mechanism for survival.
format	article
author	James D San Antonio Mary H Schweitzer Shane T Jensen Raghu Kalluri Michael Buckley Joseph P R O Orgel
author_facet	James D San Antonio Mary H Schweitzer Shane T Jensen Raghu Kalluri Michael Buckley Joseph P R O Orgel
author_sort	James D San Antonio
title	Dinosaur peptides suggest mechanisms of protein survival.
title_short	Dinosaur peptides suggest mechanisms of protein survival.
title_full	Dinosaur peptides suggest mechanisms of protein survival.
title_fullStr	Dinosaur peptides suggest mechanisms of protein survival.
title_full_unstemmed	Dinosaur peptides suggest mechanisms of protein survival.
title_sort	dinosaur peptides suggest mechanisms of protein survival.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/74608424e5534a7d8f329ffdb7b4f4ad
work_keys_str_mv	AT jamesdsanantonio dinosaurpeptidessuggestmechanismsofproteinsurvival AT maryhschweitzer dinosaurpeptidessuggestmechanismsofproteinsurvival AT shanetjensen dinosaurpeptidessuggestmechanismsofproteinsurvival AT raghukalluri dinosaurpeptidessuggestmechanismsofproteinsurvival AT michaelbuckley dinosaurpeptidessuggestmechanismsofproteinsurvival AT josephproorgel dinosaurpeptidessuggestmechanismsofproteinsurvival
_version_	1718424301020905472

Dinosaur peptides suggest mechanisms of protein survival.

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