Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing

Interaction between SETD2 and hnRNP L has previously been shown to be implicated in coupling gene transcription and mRNA processing. Here the authors elucidate the molecular basis of this functional interaction, showing that the RRM domain of hnRNP L possesses non-overlapping binding interfaces for...

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Autores principales:	Saikat Bhattacharya, Suman Wang, Divya Reddy, Siyuan Shen, Ying Zhang, Ning Zhang, Hua Li, Michael P. Washburn, Laurence Florens, Yunyu Shi, Jerry L. Workman, Fudong Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/746237619b684f9fad10fcff1640f5ab
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spelling	oai:doaj.org-article:746237619b684f9fad10fcff1640f5ab2021-11-14T12:34:11ZStructural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing10.1038/s41467-021-26799-32041-1723https://doaj.org/article/746237619b684f9fad10fcff1640f5ab2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26799-3https://doaj.org/toc/2041-1723Interaction between SETD2 and hnRNP L has previously been shown to be implicated in coupling gene transcription and mRNA processing. Here the authors elucidate the molecular basis of this functional interaction, showing that the RRM domain of hnRNP L possesses non-overlapping binding interfaces for engaging RNA and SETD2.Saikat BhattacharyaSuman WangDivya ReddySiyuan ShenYing ZhangNing ZhangHua LiMichael P. WashburnLaurence FlorensYunyu ShiJerry L. WorkmanFudong LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saikat Bhattacharya Suman Wang Divya Reddy Siyuan Shen Ying Zhang Ning Zhang Hua Li Michael P. Washburn Laurence Florens Yunyu Shi Jerry L. Workman Fudong Li Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing
description	Interaction between SETD2 and hnRNP L has previously been shown to be implicated in coupling gene transcription and mRNA processing. Here the authors elucidate the molecular basis of this functional interaction, showing that the RRM domain of hnRNP L possesses non-overlapping binding interfaces for engaging RNA and SETD2.
format	article
author	Saikat Bhattacharya Suman Wang Divya Reddy Siyuan Shen Ying Zhang Ning Zhang Hua Li Michael P. Washburn Laurence Florens Yunyu Shi Jerry L. Workman Fudong Li
author_facet	Saikat Bhattacharya Suman Wang Divya Reddy Siyuan Shen Ying Zhang Ning Zhang Hua Li Michael P. Washburn Laurence Florens Yunyu Shi Jerry L. Workman Fudong Li
author_sort	Saikat Bhattacharya
title	Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing
title_short	Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing
title_full	Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing
title_fullStr	Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing
title_full_unstemmed	Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing
title_sort	structural basis of the interaction between setd2 methyltransferase and hnrnp l paralogs for governing co-transcriptional splicing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/746237619b684f9fad10fcff1640f5ab
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Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing

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