Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve
Bicuspid aortic valve (BAV) is the most common human congenital cardiovascular malformation. Here, the authors perform a genome-wide association study for BAV and identify risk variants in the gene region of cardiac-specific transcription factor GATA4 and implicate GATA4 in heart valve development.
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Nature Portfolio
2017
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oai:doaj.org-article:746483d8d43040b4bb874c6651724a722021-12-02T15:38:53ZProtein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve10.1038/ncomms154812041-1723https://doaj.org/article/746483d8d43040b4bb874c6651724a722017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15481https://doaj.org/toc/2041-1723Bicuspid aortic valve (BAV) is the most common human congenital cardiovascular malformation. Here, the authors perform a genome-wide association study for BAV and identify risk variants in the gene region of cardiac-specific transcription factor GATA4 and implicate GATA4 in heart valve development.Bo YangWei ZhouJiao JiaoJonas B. NielsenMichael R. MathisMahyar HeydarpourGuillaume LettreLasse FolkersenSiddharth PrakashClaudia SchurmannLars FritscheGregory A. FarnumMaoxuan LinMohammad OthmanWhitney HornsbyAnisa DriscollAlexandra LevasseurMarc ThomasLinda FarhatMarie-Pierre DubéEric M. IsselbacherAnders Franco-CerecedaDong-chuan GuoErwin P. BottingerG. Michael DeebAnna BooherSachin KheterpalY. Eugene ChenHyun Min KangJacob KitzmanHeather J. CordellBernard D. KeavneyJudith A. GoodshipSanthi K. GaneshGonçalo AbecasisKim A. EagleAlan P. BoyleRuth J. F. LoosPer ErikssonJean-Claude TardifChad M. BrummettDianna M. MilewiczSimon C. BodyCristen J. WillerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
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DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
| spellingShingle |
Science Q Bo Yang Wei Zhou Jiao Jiao Jonas B. Nielsen Michael R. Mathis Mahyar Heydarpour Guillaume Lettre Lasse Folkersen Siddharth Prakash Claudia Schurmann Lars Fritsche Gregory A. Farnum Maoxuan Lin Mohammad Othman Whitney Hornsby Anisa Driscoll Alexandra Levasseur Marc Thomas Linda Farhat Marie-Pierre Dubé Eric M. Isselbacher Anders Franco-Cereceda Dong-chuan Guo Erwin P. Bottinger G. Michael Deeb Anna Booher Sachin Kheterpal Y. Eugene Chen Hyun Min Kang Jacob Kitzman Heather J. Cordell Bernard D. Keavney Judith A. Goodship Santhi K. Ganesh Gonçalo Abecasis Kim A. Eagle Alan P. Boyle Ruth J. F. Loos Per Eriksson Jean-Claude Tardif Chad M. Brummett Dianna M. Milewicz Simon C. Body Cristen J. Willer Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve |
| description |
Bicuspid aortic valve (BAV) is the most common human congenital cardiovascular malformation. Here, the authors perform a genome-wide association study for BAV and identify risk variants in the gene region of cardiac-specific transcription factor GATA4 and implicate GATA4 in heart valve development. |
| format |
article |
| author |
Bo Yang Wei Zhou Jiao Jiao Jonas B. Nielsen Michael R. Mathis Mahyar Heydarpour Guillaume Lettre Lasse Folkersen Siddharth Prakash Claudia Schurmann Lars Fritsche Gregory A. Farnum Maoxuan Lin Mohammad Othman Whitney Hornsby Anisa Driscoll Alexandra Levasseur Marc Thomas Linda Farhat Marie-Pierre Dubé Eric M. Isselbacher Anders Franco-Cereceda Dong-chuan Guo Erwin P. Bottinger G. Michael Deeb Anna Booher Sachin Kheterpal Y. Eugene Chen Hyun Min Kang Jacob Kitzman Heather J. Cordell Bernard D. Keavney Judith A. Goodship Santhi K. Ganesh Gonçalo Abecasis Kim A. Eagle Alan P. Boyle Ruth J. F. Loos Per Eriksson Jean-Claude Tardif Chad M. Brummett Dianna M. Milewicz Simon C. Body Cristen J. Willer |
| author_facet |
Bo Yang Wei Zhou Jiao Jiao Jonas B. Nielsen Michael R. Mathis Mahyar Heydarpour Guillaume Lettre Lasse Folkersen Siddharth Prakash Claudia Schurmann Lars Fritsche Gregory A. Farnum Maoxuan Lin Mohammad Othman Whitney Hornsby Anisa Driscoll Alexandra Levasseur Marc Thomas Linda Farhat Marie-Pierre Dubé Eric M. Isselbacher Anders Franco-Cereceda Dong-chuan Guo Erwin P. Bottinger G. Michael Deeb Anna Booher Sachin Kheterpal Y. Eugene Chen Hyun Min Kang Jacob Kitzman Heather J. Cordell Bernard D. Keavney Judith A. Goodship Santhi K. Ganesh Gonçalo Abecasis Kim A. Eagle Alan P. Boyle Ruth J. F. Loos Per Eriksson Jean-Claude Tardif Chad M. Brummett Dianna M. Milewicz Simon C. Body Cristen J. Willer |
| author_sort |
Bo Yang |
| title |
Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve |
| title_short |
Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve |
| title_full |
Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve |
| title_fullStr |
Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve |
| title_full_unstemmed |
Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve |
| title_sort |
protein-altering and regulatory genetic variants near gata4 implicated in bicuspid aortic valve |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/746483d8d43040b4bb874c6651724a72 |
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