Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics

ABSTRACT Over the past 10 years, microbiome research has focused on defining the structures associated with different disease states in multiple systems, but has fallen short on showing causation. Prior omic studies have generated many new hypotheses, but moving forward we need to start dissecting t...

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Autor principal:	Casey M. Theriot
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	Clostridium difficile bile acids metabolome microbiota obesity therapeutics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7465be709b0d4102b4c561f57fe92e83
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spelling	oai:doaj.org-article:7465be709b0d4102b4c561f57fe92e832021-12-02T19:46:20ZBeyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics10.1128/mSystems.00173-172379-5077https://doaj.org/article/7465be709b0d4102b4c561f57fe92e832018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00173-17https://doaj.org/toc/2379-5077ABSTRACT Over the past 10 years, microbiome research has focused on defining the structures associated with different disease states in multiple systems, but has fallen short on showing causation. Prior omic studies have generated many new hypotheses, but moving forward we need to start dissecting the function of each bacterium alone and in concert with complex bacterial communities in well-characterized systems. Over the next 5 years, we need a merging of new omic technologies for exploratory studies with classical bacterial genetics, bacterial physiology, protein engineering, and biochemistry to further define the biochemical mechanisms of the gut microbiota. The future of the systems microbiology field will focus on targeted engineering and editing of the microbiome to alter function, which will be leveraged to prevent and/or treat human diseases. This perspective will focus on my contribution to the microbiome field, both past and present, and where I think research in the field is headed in the near future.Casey M. TheriotAmerican Society for MicrobiologyarticleClostridium difficilebile acidsmetabolomemicrobiotaobesitytherapeuticsMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Clostridium difficile bile acids metabolome microbiota obesity therapeutics Microbiology QR1-502
spellingShingle	Clostridium difficile bile acids metabolome microbiota obesity therapeutics Microbiology QR1-502 Casey M. Theriot Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics
description	ABSTRACT Over the past 10 years, microbiome research has focused on defining the structures associated with different disease states in multiple systems, but has fallen short on showing causation. Prior omic studies have generated many new hypotheses, but moving forward we need to start dissecting the function of each bacterium alone and in concert with complex bacterial communities in well-characterized systems. Over the next 5 years, we need a merging of new omic technologies for exploratory studies with classical bacterial genetics, bacterial physiology, protein engineering, and biochemistry to further define the biochemical mechanisms of the gut microbiota. The future of the systems microbiology field will focus on targeted engineering and editing of the microbiome to alter function, which will be leveraged to prevent and/or treat human diseases. This perspective will focus on my contribution to the microbiome field, both past and present, and where I think research in the field is headed in the near future.
format	article
author	Casey M. Theriot
author_facet	Casey M. Theriot
author_sort	Casey M. Theriot
title	Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics
title_short	Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics
title_full	Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics
title_fullStr	Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics
title_full_unstemmed	Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics
title_sort	beyond structure: defining the function of the gut using omic approaches for rational design of personalized therapeutics
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/7465be709b0d4102b4c561f57fe92e83
work_keys_str_mv	AT caseymtheriot beyondstructuredefiningthefunctionofthegutusingomicapproachesforrationaldesignofpersonalizedtherapeutics
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Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics

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