T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine

How transcription factor T-bet and Th17 cells contribute to colitis remains incompletely understood. Here the authors identify T-bet as a negative regulator of IL-23R pathway activation and show that T-bet deficient T cells drive colitogenic Th17 responses dependent on the cytokines IL-17A and IL-22...

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Autores principales:	Thomas Krausgruber, Chris Schiering, Krista Adelmann, Oliver J. Harrison, Agnieszka Chomka, Claire Pearson, Philip P. Ahern, Matthew Shale, Mohamed Oukka, Fiona Powrie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7468206667654e0d9f30482bda325b7b
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spelling	oai:doaj.org-article:7468206667654e0d9f30482bda325b7b2021-12-02T17:31:35ZT-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine10.1038/ncomms116272041-1723https://doaj.org/article/7468206667654e0d9f30482bda325b7b2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11627https://doaj.org/toc/2041-1723How transcription factor T-bet and Th17 cells contribute to colitis remains incompletely understood. Here the authors identify T-bet as a negative regulator of IL-23R pathway activation and show that T-bet deficient T cells drive colitogenic Th17 responses dependent on the cytokines IL-17A and IL-22.Thomas KrausgruberChris SchieringKrista AdelmannOliver J. HarrisonAgnieszka ChomkaClaire PearsonPhilip P. AhernMatthew ShaleMohamed OukkaFiona PowrieNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Krausgruber Chris Schiering Krista Adelmann Oliver J. Harrison Agnieszka Chomka Claire Pearson Philip P. Ahern Matthew Shale Mohamed Oukka Fiona Powrie T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine
description	How transcription factor T-bet and Th17 cells contribute to colitis remains incompletely understood. Here the authors identify T-bet as a negative regulator of IL-23R pathway activation and show that T-bet deficient T cells drive colitogenic Th17 responses dependent on the cytokines IL-17A and IL-22.
format	article
author	Thomas Krausgruber Chris Schiering Krista Adelmann Oliver J. Harrison Agnieszka Chomka Claire Pearson Philip P. Ahern Matthew Shale Mohamed Oukka Fiona Powrie
author_facet	Thomas Krausgruber Chris Schiering Krista Adelmann Oliver J. Harrison Agnieszka Chomka Claire Pearson Philip P. Ahern Matthew Shale Mohamed Oukka Fiona Powrie
author_sort	Thomas Krausgruber
title	T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine
title_short	T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine
title_full	T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine
title_fullStr	T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine
title_full_unstemmed	T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine
title_sort	t-bet is a key modulator of il-23-driven pathogenic cd4+ t cell responses in the intestine
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7468206667654e0d9f30482bda325b7b
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T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine

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