Real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process

Abstract The online real-time particle size analysis of the microencapsules manufacturing process using the continuous solvent evaporation method was performed using focused beam reflectance measurement (FBRM). In this paper, we use FBRM measurements to investigate the effects of polymer type and co...

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Autores principales:	Muhaimin Muhaimin, Anis Yohana Chaerunisaa, Roland Bodmeier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74696acb168445888b207f94f961c5fb
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spelling	oai:doaj.org-article:74696acb168445888b207f94f961c5fb2021-12-02T17:37:40ZReal-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process10.1038/s41598-021-98984-92045-2322https://doaj.org/article/74696acb168445888b207f94f961c5fb2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98984-9https://doaj.org/toc/2045-2322Abstract The online real-time particle size analysis of the microencapsules manufacturing process using the continuous solvent evaporation method was performed using focused beam reflectance measurement (FBRM). In this paper, we use FBRM measurements to investigate the effects of polymer type and compare the size distributions to those obtained using other sizing methods such as optical microscope and laser diffraction. FBRM was also utilized to measure the length-weighted chord length distribution (CLD) and particle size distribution (PSD) online during particle solidification, which could not be done with laser diffraction or nested sieve analysis. The chord lengths and CLD data were taken at specific times using an online FBRM probe mounted below the microparticle. The timing of the FBRM determinations was coordinated with the selection of microparticle samples for particle size analysis by optical microscope and laser diffraction calculation as a reference. For all three produced batches tested, FBRM, laser diffraction, and sieve analysis yielded similar results. Hardening time for the transformation of emulsion droplets into solid microparticles occurred within the first 10.5, 19, 25, 30, and 55 min, according to FBRM results. The FBRM CLDs revealed that a larger particle size mean resulted in a longer CLD and a lower peak of particle number. The FBRM data revealed that the polymer type had a significant impact on microparticle CLD and the transformation process.Muhaimin MuhaiminAnis Yohana ChaerunisaaRoland BodmeierNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muhaimin Muhaimin Anis Yohana Chaerunisaa Roland Bodmeier Real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process
description	Abstract The online real-time particle size analysis of the microencapsules manufacturing process using the continuous solvent evaporation method was performed using focused beam reflectance measurement (FBRM). In this paper, we use FBRM measurements to investigate the effects of polymer type and compare the size distributions to those obtained using other sizing methods such as optical microscope and laser diffraction. FBRM was also utilized to measure the length-weighted chord length distribution (CLD) and particle size distribution (PSD) online during particle solidification, which could not be done with laser diffraction or nested sieve analysis. The chord lengths and CLD data were taken at specific times using an online FBRM probe mounted below the microparticle. The timing of the FBRM determinations was coordinated with the selection of microparticle samples for particle size analysis by optical microscope and laser diffraction calculation as a reference. For all three produced batches tested, FBRM, laser diffraction, and sieve analysis yielded similar results. Hardening time for the transformation of emulsion droplets into solid microparticles occurred within the first 10.5, 19, 25, 30, and 55 min, according to FBRM results. The FBRM CLDs revealed that a larger particle size mean resulted in a longer CLD and a lower peak of particle number. The FBRM data revealed that the polymer type had a significant impact on microparticle CLD and the transformation process.
format	article
author	Muhaimin Muhaimin Anis Yohana Chaerunisaa Roland Bodmeier
author_facet	Muhaimin Muhaimin Anis Yohana Chaerunisaa Roland Bodmeier
author_sort	Muhaimin Muhaimin
title	Real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process
title_short	Real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process
title_full	Real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process
title_fullStr	Real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process
title_full_unstemmed	Real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process
title_sort	real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74696acb168445888b207f94f961c5fb
work_keys_str_mv	AT muhaiminmuhaimin realtimeparticlesizeanalysisusingfocusedbeamreflectancemeasurementasaprocessanalyticaltechnologytoolforcontinuousmicroencapsulationprocess AT anisyohanachaerunisaa realtimeparticlesizeanalysisusingfocusedbeamreflectancemeasurementasaprocessanalyticaltechnologytoolforcontinuousmicroencapsulationprocess AT rolandbodmeier realtimeparticlesizeanalysisusingfocusedbeamreflectancemeasurementasaprocessanalyticaltechnologytoolforcontinuousmicroencapsulationprocess
_version_	1718379890070257664

Real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process

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