Myocardial Recovery and the Failing Heart: Medical, Device and Mechanical Methods
Background: Cardiac remodeling describes the molecular, cellular, and interstitial changes that cause the ventricle to develop pathologic geometry as heart failure progresses. Reverse remodeling, or the healing of a failing heart, leads to improved mortality and quality of life. Findings: Therapies...
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| Main Authors: | , |
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| Format: | article |
| Language: | EN |
| Published: |
Ubiquity Press
2014
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| Subjects: | |
| Online Access: | https://doaj.org/article/746ea9985a414359a30e50d5c6d8dbce |
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| Summary: | Background: Cardiac remodeling describes the molecular, cellular, and interstitial changes that cause the ventricle to develop pathologic geometry as heart failure progresses. Reverse remodeling, or the healing of a failing heart, leads to improved mortality and quality of life. Findings: Therapies that lead to reverse remodeling include medications such as β-blockers and angiotensin-converting enzyme inhibitors; cardiac resynchronization therapy with biventricular pacing; and mechanical support with left ventricular assist devices. Conclusions: Further study is needed to better predict which patients will benefit most from these therapies and will then go on to experience reverse remodeling and myocardial recovery. |
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