Topological isolation of developmental regulators in mammalian genomes

The phenotypic consequence of 3D genome boundary disruption on developmental processes remains insufficiently understood. Here, the authors show that perturbation of a SOX17 boundary in human pluripotent stem cells interferes with proper differentiation and that germline variations affecting such bo...

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Autores principales:	Hua-Jun Wu, Alexandro Landshammer, Elena K. Stamenova, Adriano Bolondi, Helene Kretzmer, Alexander Meissner, Franziska Michor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74703824e0ed457c97e98fe375a89f8b
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spelling	oai:doaj.org-article:74703824e0ed457c97e98fe375a89f8b2021-12-02T18:50:52ZTopological isolation of developmental regulators in mammalian genomes10.1038/s41467-021-24951-72041-1723https://doaj.org/article/74703824e0ed457c97e98fe375a89f8b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24951-7https://doaj.org/toc/2041-1723The phenotypic consequence of 3D genome boundary disruption on developmental processes remains insufficiently understood. Here, the authors show that perturbation of a SOX17 boundary in human pluripotent stem cells interferes with proper differentiation and that germline variations affecting such boundaries are subject to selection, resulting in underrepresentation in the human population.Hua-Jun WuAlexandro LandshammerElena K. StamenovaAdriano BolondiHelene KretzmerAlexander MeissnerFranziska MichorNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hua-Jun Wu Alexandro Landshammer Elena K. Stamenova Adriano Bolondi Helene Kretzmer Alexander Meissner Franziska Michor Topological isolation of developmental regulators in mammalian genomes
description	The phenotypic consequence of 3D genome boundary disruption on developmental processes remains insufficiently understood. Here, the authors show that perturbation of a SOX17 boundary in human pluripotent stem cells interferes with proper differentiation and that germline variations affecting such boundaries are subject to selection, resulting in underrepresentation in the human population.
format	article
author	Hua-Jun Wu Alexandro Landshammer Elena K. Stamenova Adriano Bolondi Helene Kretzmer Alexander Meissner Franziska Michor
author_facet	Hua-Jun Wu Alexandro Landshammer Elena K. Stamenova Adriano Bolondi Helene Kretzmer Alexander Meissner Franziska Michor
author_sort	Hua-Jun Wu
title	Topological isolation of developmental regulators in mammalian genomes
title_short	Topological isolation of developmental regulators in mammalian genomes
title_full	Topological isolation of developmental regulators in mammalian genomes
title_fullStr	Topological isolation of developmental regulators in mammalian genomes
title_full_unstemmed	Topological isolation of developmental regulators in mammalian genomes
title_sort	topological isolation of developmental regulators in mammalian genomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74703824e0ed457c97e98fe375a89f8b
work_keys_str_mv	AT huajunwu topologicalisolationofdevelopmentalregulatorsinmammaliangenomes AT alexandrolandshammer topologicalisolationofdevelopmentalregulatorsinmammaliangenomes AT elenakstamenova topologicalisolationofdevelopmentalregulatorsinmammaliangenomes AT adrianobolondi topologicalisolationofdevelopmentalregulatorsinmammaliangenomes AT helenekretzmer topologicalisolationofdevelopmentalregulatorsinmammaliangenomes AT alexandermeissner topologicalisolationofdevelopmentalregulatorsinmammaliangenomes AT franziskamichor topologicalisolationofdevelopmentalregulatorsinmammaliangenomes
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Topological isolation of developmental regulators in mammalian genomes

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