Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma

There is an unmet clinical need to identify therapeutic options for the treatment of pancreatic cancer (PDAC). Here the authors present a systematic screening approach for the identification of potential PDAC cell surface target candidates for CAR-T cell based immunotherapy, followed by their functi...

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Autores principales:	Daniel Schäfer, Stefan Tomiuk, Laura N. Küster, Wa’el Al Rawashdeh, Janina Henze, German Tischler-Höhle, David J. Agorku, Janina Brauner, Cathrin Linnartz, Dominik Lock, Andrew Kaiser, Christoph Herbel, Dominik Eckardt, Melina Lamorte, Dorothee Lenhard, Julia Schüler, Philipp Ströbel, Jeannine Missbach-Guentner, Diana Pinkert-Leetsch, Frauke Alves, Andreas Bosio, Olaf Hardt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74706aa5d24748cbad4a75025edf6014
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spelling	oai:doaj.org-article:74706aa5d24748cbad4a75025edf60142021-12-02T13:33:01ZIdentification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma10.1038/s41467-021-21774-42041-1723https://doaj.org/article/74706aa5d24748cbad4a75025edf60142021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21774-4https://doaj.org/toc/2041-1723There is an unmet clinical need to identify therapeutic options for the treatment of pancreatic cancer (PDAC). Here the authors present a systematic screening approach for the identification of potential PDAC cell surface target candidates for CAR-T cell based immunotherapy, followed by their functional validation in preclinical models.Daniel SchäferStefan TomiukLaura N. KüsterWa’el Al RawashdehJanina HenzeGerman Tischler-HöhleDavid J. AgorkuJanina BraunerCathrin LinnartzDominik LockAndrew KaiserChristoph HerbelDominik EckardtMelina LamorteDorothee LenhardJulia SchülerPhilipp StröbelJeannine Missbach-GuentnerDiana Pinkert-LeetschFrauke AlvesAndreas BosioOlaf HardtNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Schäfer Stefan Tomiuk Laura N. Küster Wa’el Al Rawashdeh Janina Henze German Tischler-Höhle David J. Agorku Janina Brauner Cathrin Linnartz Dominik Lock Andrew Kaiser Christoph Herbel Dominik Eckardt Melina Lamorte Dorothee Lenhard Julia Schüler Philipp Ströbel Jeannine Missbach-Guentner Diana Pinkert-Leetsch Frauke Alves Andreas Bosio Olaf Hardt Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma
description	There is an unmet clinical need to identify therapeutic options for the treatment of pancreatic cancer (PDAC). Here the authors present a systematic screening approach for the identification of potential PDAC cell surface target candidates for CAR-T cell based immunotherapy, followed by their functional validation in preclinical models.
format	article
author	Daniel Schäfer Stefan Tomiuk Laura N. Küster Wa’el Al Rawashdeh Janina Henze German Tischler-Höhle David J. Agorku Janina Brauner Cathrin Linnartz Dominik Lock Andrew Kaiser Christoph Herbel Dominik Eckardt Melina Lamorte Dorothee Lenhard Julia Schüler Philipp Ströbel Jeannine Missbach-Guentner Diana Pinkert-Leetsch Frauke Alves Andreas Bosio Olaf Hardt
author_facet	Daniel Schäfer Stefan Tomiuk Laura N. Küster Wa’el Al Rawashdeh Janina Henze German Tischler-Höhle David J. Agorku Janina Brauner Cathrin Linnartz Dominik Lock Andrew Kaiser Christoph Herbel Dominik Eckardt Melina Lamorte Dorothee Lenhard Julia Schüler Philipp Ströbel Jeannine Missbach-Guentner Diana Pinkert-Leetsch Frauke Alves Andreas Bosio Olaf Hardt
author_sort	Daniel Schäfer
title	Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma
title_short	Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma
title_full	Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma
title_fullStr	Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma
title_full_unstemmed	Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma
title_sort	identification of cd318, tspan8 and cd66c as target candidates for car t cell based immunotherapy of pancreatic adenocarcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74706aa5d24748cbad4a75025edf6014
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Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma

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