White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa

Abstract Anorexia nervosa (AN) is a difficult to treat, pernicious psychiatric disorder that has been linked to decision-making abnormalities. We examined the structural characteristics of habitual and goal-directed decision-making circuits and their connecting white matter tracts in 32 AN and 43 he...

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Autores principales:	Reza Tadayonnejad, Fabrizio Pizzagalli, Stuart B. Murray, Wolfgang M. Pauli, Geena Conde, Ausaf A. Bari, Michael Strober, John P. O’Doherty, Jamie D. Feusner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74759503c24249e6808c68841e5182e3
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spelling	oai:doaj.org-article:74759503c24249e6808c68841e5182e32021-12-02T17:06:31ZWhite matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa10.1038/s41598-021-95300-32045-2322https://doaj.org/article/74759503c24249e6808c68841e5182e32021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95300-3https://doaj.org/toc/2045-2322Abstract Anorexia nervosa (AN) is a difficult to treat, pernicious psychiatric disorder that has been linked to decision-making abnormalities. We examined the structural characteristics of habitual and goal-directed decision-making circuits and their connecting white matter tracts in 32 AN and 43 healthy controls across two independent data sets of adults and adolescents as an explanatory sub-study. Total bilateral premotor/supplementary motor area-putamen tracts in the habit circuit had a significantly higher volume in adults with AN, relative to controls. Positive correlations were found between both the number of tracts and white matter volume (WMV) in the habit circuit, and the severity of ritualistic/compulsive behaviors in adults and adolescents with AN. Moreover, we found a significant influence of the habit circuit WMV on AN ritualistic/compulsive symptom severity, depending on the preoccupations symptom severity levels. These findings suggest that AN is associated with white matter plasticity alterations in the habit circuit. The association between characteristics of habit circuit white matter tracts and AN behavioral symptoms provides support for a circuit based neurobiological model of AN, and identifies the habit circuit as a focus for further investigation to aid in development of novel and more effective treatments based on brain-behavior relationships.Reza TadayonnejadFabrizio PizzagalliStuart B. MurrayWolfgang M. PauliGeena CondeAusaf A. BariMichael StroberJohn P. O’DohertyJamie D. FeusnerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Reza Tadayonnejad Fabrizio Pizzagalli Stuart B. Murray Wolfgang M. Pauli Geena Conde Ausaf A. Bari Michael Strober John P. O’Doherty Jamie D. Feusner White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa
description	Abstract Anorexia nervosa (AN) is a difficult to treat, pernicious psychiatric disorder that has been linked to decision-making abnormalities. We examined the structural characteristics of habitual and goal-directed decision-making circuits and their connecting white matter tracts in 32 AN and 43 healthy controls across two independent data sets of adults and adolescents as an explanatory sub-study. Total bilateral premotor/supplementary motor area-putamen tracts in the habit circuit had a significantly higher volume in adults with AN, relative to controls. Positive correlations were found between both the number of tracts and white matter volume (WMV) in the habit circuit, and the severity of ritualistic/compulsive behaviors in adults and adolescents with AN. Moreover, we found a significant influence of the habit circuit WMV on AN ritualistic/compulsive symptom severity, depending on the preoccupations symptom severity levels. These findings suggest that AN is associated with white matter plasticity alterations in the habit circuit. The association between characteristics of habit circuit white matter tracts and AN behavioral symptoms provides support for a circuit based neurobiological model of AN, and identifies the habit circuit as a focus for further investigation to aid in development of novel and more effective treatments based on brain-behavior relationships.
format	article
author	Reza Tadayonnejad Fabrizio Pizzagalli Stuart B. Murray Wolfgang M. Pauli Geena Conde Ausaf A. Bari Michael Strober John P. O’Doherty Jamie D. Feusner
author_facet	Reza Tadayonnejad Fabrizio Pizzagalli Stuart B. Murray Wolfgang M. Pauli Geena Conde Ausaf A. Bari Michael Strober John P. O’Doherty Jamie D. Feusner
author_sort	Reza Tadayonnejad
title	White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa
title_short	White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa
title_full	White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa
title_fullStr	White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa
title_full_unstemmed	White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa
title_sort	white matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/74759503c24249e6808c68841e5182e3
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White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa

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