INTERLEUKIN-2 – AND INTERFERON-ALPHA- INDUCED CHANGES OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN CHILDREN WITH ADVANCED MALIGNANCIES, TREATED WITH CHEMOTHERAPY AND WHOLE BODY HYPERTHERMIA

Abstract. The effect of cytokine preparations (Interleukin-2/IL-2/Proleukin and interferon-alpha/IFN-α 2b/ Intron A) on immune cell subpopulations has been studied in the children suffering with advanced malignancies during intensive chemotherapy cycles combined with whole body hyperthermia (thermoc...

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Autores principales:	R. S. Ismail-zade, M. V. Belevtsev, M. P. Potapnev, V. P. Savitskiy, E. A. Zhavrid, S. E. Buglova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	il-2 interferon-alpha whole-body hyperthermia malignancies children Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7475e8f5dfb74f3a8de1d60d6ba8d136
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spelling	oai:doaj.org-article:7475e8f5dfb74f3a8de1d60d6ba8d1362021-11-18T08:03:42ZINTERLEUKIN-2 – AND INTERFERON-ALPHA- INDUCED CHANGES OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN CHILDREN WITH ADVANCED MALIGNANCIES, TREATED WITH CHEMOTHERAPY AND WHOLE BODY HYPERTHERMIA1563-06252313-741X10.15789/1563-0625-2006-4-561-566https://doaj.org/article/7475e8f5dfb74f3a8de1d60d6ba8d1362014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/501https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The effect of cytokine preparations (Interleukin-2/IL-2/Proleukin and interferon-alpha/IFN-α 2b/ Intron A) on immune cell subpopulations has been studied in the children suffering with advanced malignancies during intensive chemotherapy cycles combined with whole body hyperthermia (thermochemotherapy). It was shown that IFN-α 2b promotes recovery of peripheral lymphocyte counts in the patients. However, no sufficient changes were observed for the lymphocyte subpopulations. Furthermore, more profound lymphopenia along with increased contents of activated (CD25+, HLA-DR+) T cells occurs in a group of children treated with IL-2, as compared to the patients who received IFN-α 2b. Besides that, some differential effects upon the CD4+/CD8+ T-cell ratios were observed in the patients treated with Proleukin or Intron A, with a tendency to increase in CD4+ T-cells for the patients treated with IL-2. It was concluded that differential immunomodulatory mechanisms mediate the effects of IL-2 and IFN-α 2b in the patients with malignancies undergoing combined chemobiotherapy with whole-body hyperthermia.R. S. Ismail-zadeM. V. BelevtsevM. P. PotapnevV. P. SavitskiyE. A. ZhavridS. E. BuglovaSPb RAACIarticleil-2interferon-alphawhole-body hyperthermiamalignancieschildrenImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 4, Pp 561-566 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	il-2 interferon-alpha whole-body hyperthermia malignancies children Immunologic diseases. Allergy RC581-607
spellingShingle	il-2 interferon-alpha whole-body hyperthermia malignancies children Immunologic diseases. Allergy RC581-607 R. S. Ismail-zade M. V. Belevtsev M. P. Potapnev V. P. Savitskiy E. A. Zhavrid S. E. Buglova INTERLEUKIN-2 – AND INTERFERON-ALPHA- INDUCED CHANGES OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN CHILDREN WITH ADVANCED MALIGNANCIES, TREATED WITH CHEMOTHERAPY AND WHOLE BODY HYPERTHERMIA
description	Abstract. The effect of cytokine preparations (Interleukin-2/IL-2/Proleukin and interferon-alpha/IFN-α 2b/ Intron A) on immune cell subpopulations has been studied in the children suffering with advanced malignancies during intensive chemotherapy cycles combined with whole body hyperthermia (thermochemotherapy). It was shown that IFN-α 2b promotes recovery of peripheral lymphocyte counts in the patients. However, no sufficient changes were observed for the lymphocyte subpopulations. Furthermore, more profound lymphopenia along with increased contents of activated (CD25+, HLA-DR+) T cells occurs in a group of children treated with IL-2, as compared to the patients who received IFN-α 2b. Besides that, some differential effects upon the CD4+/CD8+ T-cell ratios were observed in the patients treated with Proleukin or Intron A, with a tendency to increase in CD4+ T-cells for the patients treated with IL-2. It was concluded that differential immunomodulatory mechanisms mediate the effects of IL-2 and IFN-α 2b in the patients with malignancies undergoing combined chemobiotherapy with whole-body hyperthermia.
format	article
author	R. S. Ismail-zade M. V. Belevtsev M. P. Potapnev V. P. Savitskiy E. A. Zhavrid S. E. Buglova
author_facet	R. S. Ismail-zade M. V. Belevtsev M. P. Potapnev V. P. Savitskiy E. A. Zhavrid S. E. Buglova
author_sort	R. S. Ismail-zade
title	INTERLEUKIN-2 – AND INTERFERON-ALPHA- INDUCED CHANGES OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN CHILDREN WITH ADVANCED MALIGNANCIES, TREATED WITH CHEMOTHERAPY AND WHOLE BODY HYPERTHERMIA
title_short	INTERLEUKIN-2 – AND INTERFERON-ALPHA- INDUCED CHANGES OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN CHILDREN WITH ADVANCED MALIGNANCIES, TREATED WITH CHEMOTHERAPY AND WHOLE BODY HYPERTHERMIA
title_full	INTERLEUKIN-2 – AND INTERFERON-ALPHA- INDUCED CHANGES OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN CHILDREN WITH ADVANCED MALIGNANCIES, TREATED WITH CHEMOTHERAPY AND WHOLE BODY HYPERTHERMIA
title_fullStr	INTERLEUKIN-2 – AND INTERFERON-ALPHA- INDUCED CHANGES OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN CHILDREN WITH ADVANCED MALIGNANCIES, TREATED WITH CHEMOTHERAPY AND WHOLE BODY HYPERTHERMIA
title_full_unstemmed	INTERLEUKIN-2 – AND INTERFERON-ALPHA- INDUCED CHANGES OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN CHILDREN WITH ADVANCED MALIGNANCIES, TREATED WITH CHEMOTHERAPY AND WHOLE BODY HYPERTHERMIA
title_sort	interleukin-2 – and interferon-alpha- induced changes of peripheral blood lymphocyte subpopulations in children with advanced malignancies, treated with chemotherapy and whole body hyperthermia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7475e8f5dfb74f3a8de1d60d6ba8d136
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INTERLEUKIN-2 – AND INTERFERON-ALPHA- INDUCED CHANGES OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN CHILDREN WITH ADVANCED MALIGNANCIES, TREATED WITH CHEMOTHERAPY AND WHOLE BODY HYPERTHERMIA

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