MXene-assisted organic electrochemical transistor biosensor with multiple spiral interdigitated electrodes for sensitive quantification of fPSA/tPSA

Abstract Background The ratio of fPSA/tPSA in the "grey zone" of tPSA with the concentration range between 4 ng/ml and 10 ng/ml is significant for diagnosis of prostate cancer, and highly efficiency quantification of the ratio of fPSA/tPSA remain elusive mainly because of their extremely l...

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Autores principales:	Yi-Cheng Zhu, Biao Cai, Quan Jiang, Yuan Zhang, Jianjun Sha, Shaowei Xie
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Prostate specific antigen Organic electrochemical transistor Multiplexed spiral Biomarker Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/7476cc5d24ee4f6cadcc24e77c955b19
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spelling	oai:doaj.org-article:7476cc5d24ee4f6cadcc24e77c955b192021-11-28T12:26:47ZMXene-assisted organic electrochemical transistor biosensor with multiple spiral interdigitated electrodes for sensitive quantification of fPSA/tPSA10.1186/s12951-021-01121-x1477-3155https://doaj.org/article/7476cc5d24ee4f6cadcc24e77c955b192021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01121-xhttps://doaj.org/toc/1477-3155Abstract Background The ratio of fPSA/tPSA in the "grey zone" of tPSA with the concentration range between 4 ng/ml and 10 ng/ml is significant for diagnosis of prostate cancer, and highly efficiency quantification of the ratio of fPSA/tPSA remain elusive mainly because of their extremely low concentration in patients' peripheral blood with high biosample complexity. Methods We presented an interdigitated spiral-based MXene-assisted organic electrochemical transistors (isMOECTs) biosensor for highly sensitive determination of fPSA/tPSA. The combination of MXene and the interdigitated multiple spiral architecture synergistically assisted the amplification of amperometric signal of biosensor with dual functionalizations of anti-tPSA and anti-fPSA. Results The ultrasensitivity of the biosensor was enhanced by tunable multiple spiral architecture and MXene nanomaterials; and the sensor exhibited improved detection limit of tPSA and fPSA down to 0.01 pg/ml and acceptable performance of selectivity, repeatability and stability. Moreover, the isMOECTs displayed area under the curve (AUC) value of 0.8138, confirming the potential applications of isMOECTs in clinics. Conclusions The merits of isMOECTs biosensor demonstrated the reliability of MXene-assisted organic electrochemical transistor biosensor with multiple interdigitated spiral for ultrasensitive quantification of fPSA/tPSA, suggesting potential current and future point-of-care testing applications. Graphical AbstractYi-Cheng ZhuBiao CaiQuan JiangYuan ZhangJianjun ShaShaowei XieBMCarticleProstate specific antigenOrganic electrochemical transistorMultiplexed spiralBiomarkerBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prostate specific antigen Organic electrochemical transistor Multiplexed spiral Biomarker Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Prostate specific antigen Organic electrochemical transistor Multiplexed spiral Biomarker Biotechnology TP248.13-248.65 Medical technology R855-855.5 Yi-Cheng Zhu Biao Cai Quan Jiang Yuan Zhang Jianjun Sha Shaowei Xie MXene-assisted organic electrochemical transistor biosensor with multiple spiral interdigitated electrodes for sensitive quantification of fPSA/tPSA
description	Abstract Background The ratio of fPSA/tPSA in the "grey zone" of tPSA with the concentration range between 4 ng/ml and 10 ng/ml is significant for diagnosis of prostate cancer, and highly efficiency quantification of the ratio of fPSA/tPSA remain elusive mainly because of their extremely low concentration in patients' peripheral blood with high biosample complexity. Methods We presented an interdigitated spiral-based MXene-assisted organic electrochemical transistors (isMOECTs) biosensor for highly sensitive determination of fPSA/tPSA. The combination of MXene and the interdigitated multiple spiral architecture synergistically assisted the amplification of amperometric signal of biosensor with dual functionalizations of anti-tPSA and anti-fPSA. Results The ultrasensitivity of the biosensor was enhanced by tunable multiple spiral architecture and MXene nanomaterials; and the sensor exhibited improved detection limit of tPSA and fPSA down to 0.01 pg/ml and acceptable performance of selectivity, repeatability and stability. Moreover, the isMOECTs displayed area under the curve (AUC) value of 0.8138, confirming the potential applications of isMOECTs in clinics. Conclusions The merits of isMOECTs biosensor demonstrated the reliability of MXene-assisted organic electrochemical transistor biosensor with multiple interdigitated spiral for ultrasensitive quantification of fPSA/tPSA, suggesting potential current and future point-of-care testing applications. Graphical Abstract
format	article
author	Yi-Cheng Zhu Biao Cai Quan Jiang Yuan Zhang Jianjun Sha Shaowei Xie
author_facet	Yi-Cheng Zhu Biao Cai Quan Jiang Yuan Zhang Jianjun Sha Shaowei Xie
author_sort	Yi-Cheng Zhu
title	MXene-assisted organic electrochemical transistor biosensor with multiple spiral interdigitated electrodes for sensitive quantification of fPSA/tPSA
title_short	MXene-assisted organic electrochemical transistor biosensor with multiple spiral interdigitated electrodes for sensitive quantification of fPSA/tPSA
title_full	MXene-assisted organic electrochemical transistor biosensor with multiple spiral interdigitated electrodes for sensitive quantification of fPSA/tPSA
title_fullStr	MXene-assisted organic electrochemical transistor biosensor with multiple spiral interdigitated electrodes for sensitive quantification of fPSA/tPSA
title_full_unstemmed	MXene-assisted organic electrochemical transistor biosensor with multiple spiral interdigitated electrodes for sensitive quantification of fPSA/tPSA
title_sort	mxene-assisted organic electrochemical transistor biosensor with multiple spiral interdigitated electrodes for sensitive quantification of fpsa/tpsa
publisher	BMC
publishDate	2021
url	https://doaj.org/article/7476cc5d24ee4f6cadcc24e77c955b19
work_keys_str_mv	AT yichengzhu mxeneassistedorganicelectrochemicaltransistorbiosensorwithmultiplespiralinterdigitatedelectrodesforsensitivequantificationoffpsatpsa AT biaocai mxeneassistedorganicelectrochemicaltransistorbiosensorwithmultiplespiralinterdigitatedelectrodesforsensitivequantificationoffpsatpsa AT quanjiang mxeneassistedorganicelectrochemicaltransistorbiosensorwithmultiplespiralinterdigitatedelectrodesforsensitivequantificationoffpsatpsa AT yuanzhang mxeneassistedorganicelectrochemicaltransistorbiosensorwithmultiplespiralinterdigitatedelectrodesforsensitivequantificationoffpsatpsa AT jianjunsha mxeneassistedorganicelectrochemicaltransistorbiosensorwithmultiplespiralinterdigitatedelectrodesforsensitivequantificationoffpsatpsa AT shaoweixie mxeneassistedorganicelectrochemicaltransistorbiosensorwithmultiplespiralinterdigitatedelectrodesforsensitivequantificationoffpsatpsa
_version_	1718407963261009920

MXene-assisted organic electrochemical transistor biosensor with multiple spiral interdigitated electrodes for sensitive quantification of fPSA/tPSA

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