Autophagy-enhancing drugs limit mucosal HIV-1 acquisition and suppress viral replication ex vivo

Autophagy-enhancing drugs limit mucosal HIV-1 acquisition and suppress viral replication ex vivo

Abstract Current direct-acting antiviral therapies are highly effective in suppressing HIV-1 replication. However, mucosal inflammation undermines prophylactic treatment efficacy, and HIV-1 persists in long-lived tissue-derived dendritic cells (DCs) and CD4+ T cells of treated patients. Host-directe...

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Main Authors: Alexandra P. M. Cloherty, Nienke H. van Teijlingen, Tracy-Jane T. H. D. Eisden, John L. van Hamme, Anusca G. Rader, Teunis B. H. Geijtenbeek, Renée R. C. E. Schreurs, Carla M. S. Ribeiro
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/747ad914bf0d46c9860d30f8766e3ccd
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