Geographical variation and factors associated with gastric cancer in Manitoba.

<h4>Objectives</h4>We investigated the spatial disparities and factors associated with gastric cancer (GC) Incidence in Manitoba.<h4>Methods</h4>We combined information from Manitoba Cancer registry and Census data to obtain an age-sex adjusted relative risk (IRR) of GC incid...

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Autores principales:	Oluwagbenga Fakanye, Harminder Singh, Danielle Desautels, Mahmoud Torabi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/747ec8ab28ad484eb0aa1ada137ae6ab
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spelling	oai:doaj.org-article:747ec8ab28ad484eb0aa1ada137ae6ab2021-12-02T20:15:33ZGeographical variation and factors associated with gastric cancer in Manitoba.1932-620310.1371/journal.pone.0253650https://doaj.org/article/747ec8ab28ad484eb0aa1ada137ae6ab2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253650https://doaj.org/toc/1932-6203<h4>Objectives</h4>We investigated the spatial disparities and factors associated with gastric cancer (GC) Incidence in Manitoba.<h4>Methods</h4>We combined information from Manitoba Cancer registry and Census data to obtain an age-sex adjusted relative risk (IRR) of GC incidence. We geocoded the IRR to the 96 regional health authority districts (RHADs) using the postal code conversion file (PCCF). Bayesian spatial and spatio-temporal Poisson regression models were used for the analysis.<h4>Results</h4>Adjusting for the effect of socio-economic score index (SESI), Indigenous, and immigrant population, 25 districts with high overall GC risk were identified. One unit increase in SESI was associated with reduced risk of cardia GC (CGC) by 14% (IRR = 0.859; 95% CI: 0.780-0.947) and the risk of non-cardia GC (NCGC) by approximately 10% (IRR = 0.898; 95% CI: 0.812-0.995); 1% increase in regional Indigenous population proportion reduced the risk of CGC by 1.4% (IRR = 0.986; 95% CI: 0.978-0.994). In the analysis stratified by sex, one unit increase in SESI reduced the risk of CGC among women by 26.2% (IRR = 0.738; 95% CI: 0.618-0.879), and a 1% increase in Indigenous population proportion reduced the risk of CGC among women by 1.9% (IRR = 0.981; 95% CI: 0.966-0.996).<h4>Conclusion</h4>Our results support a significant association between SESI and NCGC. We report regional variation of GC IRR and a varying temporal pattern across the RHADs. These results could be used to prioritize interventions for regions with high and progressive risk of GC.Oluwagbenga FakanyeHarminder SinghDanielle DesautelsMahmoud TorabiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253650 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Oluwagbenga Fakanye Harminder Singh Danielle Desautels Mahmoud Torabi Geographical variation and factors associated with gastric cancer in Manitoba.
description	<h4>Objectives</h4>We investigated the spatial disparities and factors associated with gastric cancer (GC) Incidence in Manitoba.<h4>Methods</h4>We combined information from Manitoba Cancer registry and Census data to obtain an age-sex adjusted relative risk (IRR) of GC incidence. We geocoded the IRR to the 96 regional health authority districts (RHADs) using the postal code conversion file (PCCF). Bayesian spatial and spatio-temporal Poisson regression models were used for the analysis.<h4>Results</h4>Adjusting for the effect of socio-economic score index (SESI), Indigenous, and immigrant population, 25 districts with high overall GC risk were identified. One unit increase in SESI was associated with reduced risk of cardia GC (CGC) by 14% (IRR = 0.859; 95% CI: 0.780-0.947) and the risk of non-cardia GC (NCGC) by approximately 10% (IRR = 0.898; 95% CI: 0.812-0.995); 1% increase in regional Indigenous population proportion reduced the risk of CGC by 1.4% (IRR = 0.986; 95% CI: 0.978-0.994). In the analysis stratified by sex, one unit increase in SESI reduced the risk of CGC among women by 26.2% (IRR = 0.738; 95% CI: 0.618-0.879), and a 1% increase in Indigenous population proportion reduced the risk of CGC among women by 1.9% (IRR = 0.981; 95% CI: 0.966-0.996).<h4>Conclusion</h4>Our results support a significant association between SESI and NCGC. We report regional variation of GC IRR and a varying temporal pattern across the RHADs. These results could be used to prioritize interventions for regions with high and progressive risk of GC.
format	article
author	Oluwagbenga Fakanye Harminder Singh Danielle Desautels Mahmoud Torabi
author_facet	Oluwagbenga Fakanye Harminder Singh Danielle Desautels Mahmoud Torabi
author_sort	Oluwagbenga Fakanye
title	Geographical variation and factors associated with gastric cancer in Manitoba.
title_short	Geographical variation and factors associated with gastric cancer in Manitoba.
title_full	Geographical variation and factors associated with gastric cancer in Manitoba.
title_fullStr	Geographical variation and factors associated with gastric cancer in Manitoba.
title_full_unstemmed	Geographical variation and factors associated with gastric cancer in Manitoba.
title_sort	geographical variation and factors associated with gastric cancer in manitoba.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/747ec8ab28ad484eb0aa1ada137ae6ab
work_keys_str_mv	AT oluwagbengafakanye geographicalvariationandfactorsassociatedwithgastriccancerinmanitoba AT harmindersingh geographicalvariationandfactorsassociatedwithgastriccancerinmanitoba AT danielledesautels geographicalvariationandfactorsassociatedwithgastriccancerinmanitoba AT mahmoudtorabi geographicalvariationandfactorsassociatedwithgastriccancerinmanitoba
_version_	1718374588787720192

Geographical variation and factors associated with gastric cancer in Manitoba.

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