A network meta-analysis on the effectiveness and safety of acupuncture in treating patients with major depressive disorder

Abstract Acupuncture is an important alternative therapy in treating major depressive disorder (MDD), but its efficacy and safety are still not well assessed. This study is the first network meta-analysis exploring the effectiveness and safety of acupuncture, common pharmacological treatments or oth...

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Autores principales:	Hu Zhichao, Lam Wai Ching, Li Huijuan, Yao Liang, Wang Zhiyu, Huang Weiyang, Bian Zhaoxiang, Zhong L. D. Linda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7481529d58194427a744cd9de4cc069b
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spelling	oai:doaj.org-article:7481529d58194427a744cd9de4cc069b2021-12-02T16:51:14ZA network meta-analysis on the effectiveness and safety of acupuncture in treating patients with major depressive disorder10.1038/s41598-021-88263-y2045-2322https://doaj.org/article/7481529d58194427a744cd9de4cc069b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88263-yhttps://doaj.org/toc/2045-2322Abstract Acupuncture is an important alternative therapy in treating major depressive disorder (MDD), but its efficacy and safety are still not well assessed. This study is the first network meta-analysis exploring the effectiveness and safety of acupuncture, common pharmacological treatments or other non-medication therapies for MDD. Eight databases including PubMed, Embase, Allied and Complementary Medicine Database, Cochrane Library, Wan Fang Data, China National Knowledge Infrastructure, China Biology Medicine disc, and Chongqing VIP Database were searched up to Jan 17, 2021. Articles were screened and selected by two reviewers independently. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to assess the certainty of the evidence. A total of 71 eligible studies were included. The network analysis results indicated that the combined interventions of electro-acupuncture (EA) with selective serotonin reuptake inhibitors (SSRIs) and manual acupuncture (MA) with SSRIs were more effective in improving depression symptoms compared with acupuncture alone, pharmacological interventions alone, or other inactive groups. Among all the regimens, EA with SSRIs was found to have the highest effect in improving depression symptoms of MDD. In addition, there were slight differences in the estimations of the various treatment durations. The combination of acupuncture and serotonin-norepinephrine reuptake inhibitors (SNRIs) was found to be more effective than SNRIs alone. In conclusion, acupuncture and its combinations could be safe and effective interventions for MDD patients. EA with SSRIs seems to be the most effective intervention among the assessed interventions. Well-designed and large-scale studies with long-term follow-up should be conducted in the future.Hu ZhichaoLam Wai ChingLi HuijuanYao LiangWang ZhiyuHuang WeiyangBian ZhaoxiangZhong L. D. LindaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hu Zhichao Lam Wai Ching Li Huijuan Yao Liang Wang Zhiyu Huang Weiyang Bian Zhaoxiang Zhong L. D. Linda A network meta-analysis on the effectiveness and safety of acupuncture in treating patients with major depressive disorder
description	Abstract Acupuncture is an important alternative therapy in treating major depressive disorder (MDD), but its efficacy and safety are still not well assessed. This study is the first network meta-analysis exploring the effectiveness and safety of acupuncture, common pharmacological treatments or other non-medication therapies for MDD. Eight databases including PubMed, Embase, Allied and Complementary Medicine Database, Cochrane Library, Wan Fang Data, China National Knowledge Infrastructure, China Biology Medicine disc, and Chongqing VIP Database were searched up to Jan 17, 2021. Articles were screened and selected by two reviewers independently. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to assess the certainty of the evidence. A total of 71 eligible studies were included. The network analysis results indicated that the combined interventions of electro-acupuncture (EA) with selective serotonin reuptake inhibitors (SSRIs) and manual acupuncture (MA) with SSRIs were more effective in improving depression symptoms compared with acupuncture alone, pharmacological interventions alone, or other inactive groups. Among all the regimens, EA with SSRIs was found to have the highest effect in improving depression symptoms of MDD. In addition, there were slight differences in the estimations of the various treatment durations. The combination of acupuncture and serotonin-norepinephrine reuptake inhibitors (SNRIs) was found to be more effective than SNRIs alone. In conclusion, acupuncture and its combinations could be safe and effective interventions for MDD patients. EA with SSRIs seems to be the most effective intervention among the assessed interventions. Well-designed and large-scale studies with long-term follow-up should be conducted in the future.
format	article
author	Hu Zhichao Lam Wai Ching Li Huijuan Yao Liang Wang Zhiyu Huang Weiyang Bian Zhaoxiang Zhong L. D. Linda
author_facet	Hu Zhichao Lam Wai Ching Li Huijuan Yao Liang Wang Zhiyu Huang Weiyang Bian Zhaoxiang Zhong L. D. Linda
author_sort	Hu Zhichao
title	A network meta-analysis on the effectiveness and safety of acupuncture in treating patients with major depressive disorder
title_short	A network meta-analysis on the effectiveness and safety of acupuncture in treating patients with major depressive disorder
title_full	A network meta-analysis on the effectiveness and safety of acupuncture in treating patients with major depressive disorder
title_fullStr	A network meta-analysis on the effectiveness and safety of acupuncture in treating patients with major depressive disorder
title_full_unstemmed	A network meta-analysis on the effectiveness and safety of acupuncture in treating patients with major depressive disorder
title_sort	network meta-analysis on the effectiveness and safety of acupuncture in treating patients with major depressive disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7481529d58194427a744cd9de4cc069b
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A network meta-analysis on the effectiveness and safety of acupuncture in treating patients with major depressive disorder

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