How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases

Wolfgang Kopp Retired Head, Diagnostikzentrum Graz, Graz 8043, AustriaCorrespondence: Wolfgang Kopp Mariatrosterstraße 41, Graz 8043, AustriaEmail w.kopp@weiz.ccAbstract: Westernized populations are plagued by a plethora of chronic non-infectious degenerative diseases, termed as &ldquo...

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Autor principal:	Kopp W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Diabetes obesity metabolic syndrome insulin hypersecretion oxidative stress Paleolithic diet pathogenesis. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/748273d2951f4f6a9fad45b1b9da3033
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spelling	oai:doaj.org-article:748273d2951f4f6a9fad45b1b9da30332021-12-02T03:21:56ZHow Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases1178-7007https://doaj.org/article/748273d2951f4f6a9fad45b1b9da30332019-10-01T00:00:00Zhttps://www.dovepress.com/how-western-diet-and-lifestyle-drive-the-pandemic-of-obesity-and-civil-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Wolfgang Kopp Retired Head, Diagnostikzentrum Graz, Graz 8043, AustriaCorrespondence: Wolfgang Kopp Mariatrosterstraße 41, Graz 8043, AustriaEmail w.kopp@weiz.ccAbstract: Westernized populations are plagued by a plethora of chronic non-infectious degenerative diseases, termed as “civilization diseases”, like obesity, diabetes, cardiovascular diseases, cancer, autoimmune diseases, Alzheimer’s disease and many more, diseases which are rare or virtually absent in hunter-gatherers and other non-westernized populations. There is a growing awareness that the cause of this amazing discrepancy lies in the profound changes in diet and lifestyle during recent human history. This paper shows that the transition from Paleolithic nutrition to Western diets, along with lack of corresponding genetic adaptations, cause significant distortions of the fine-tuned metabolism that has evolved over millions of years of human evolution in adaptation to Paleolithic diets. With the increasing spread of Western diet and lifestyle worldwide, overweight and civilization diseases are also rapidly increasing in developing countries. It is suggested that the diet-related key changes in the developmental process include an increased production of reactive oxygen species and oxidative stress, development of hyperinsulinemia and insulin resistance, low-grade inflammation and an abnormal activation of the sympathetic nervous system and the renin-angiotensin system, all of which play pivotal roles in the development of diseases of civilization. In addition, diet-related epigenetic changes and fetal programming play an important role. The suggested pathomechanism is also able to explain the well-known but not completely understood close relationship between obesity and the wide range of comorbidities, like type 2 diabetes mellitus, cardiovascular disease, etc., as diseases of the same etiopathology. Changing our lifestyle in accordance with our genetic makeup, including diet and physical activity, may help prevent or limit the development of these diseases.Keywords: diabetes, obesity, metabolic syndrome, insulin hypersecretion, oxidative stress, paleolithic diet, pathogenesisKopp WDove Medical PressarticleDiabetesobesitymetabolic syndromeinsulin hypersecretionoxidative stressPaleolithic dietpathogenesis.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 2221-2236 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diabetes obesity metabolic syndrome insulin hypersecretion oxidative stress Paleolithic diet pathogenesis. Specialties of internal medicine RC581-951
spellingShingle	Diabetes obesity metabolic syndrome insulin hypersecretion oxidative stress Paleolithic diet pathogenesis. Specialties of internal medicine RC581-951 Kopp W How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
description	Wolfgang Kopp Retired Head, Diagnostikzentrum Graz, Graz 8043, AustriaCorrespondence: Wolfgang Kopp Mariatrosterstraße 41, Graz 8043, AustriaEmail w.kopp@weiz.ccAbstract: Westernized populations are plagued by a plethora of chronic non-infectious degenerative diseases, termed as “civilization diseases”, like obesity, diabetes, cardiovascular diseases, cancer, autoimmune diseases, Alzheimer’s disease and many more, diseases which are rare or virtually absent in hunter-gatherers and other non-westernized populations. There is a growing awareness that the cause of this amazing discrepancy lies in the profound changes in diet and lifestyle during recent human history. This paper shows that the transition from Paleolithic nutrition to Western diets, along with lack of corresponding genetic adaptations, cause significant distortions of the fine-tuned metabolism that has evolved over millions of years of human evolution in adaptation to Paleolithic diets. With the increasing spread of Western diet and lifestyle worldwide, overweight and civilization diseases are also rapidly increasing in developing countries. It is suggested that the diet-related key changes in the developmental process include an increased production of reactive oxygen species and oxidative stress, development of hyperinsulinemia and insulin resistance, low-grade inflammation and an abnormal activation of the sympathetic nervous system and the renin-angiotensin system, all of which play pivotal roles in the development of diseases of civilization. In addition, diet-related epigenetic changes and fetal programming play an important role. The suggested pathomechanism is also able to explain the well-known but not completely understood close relationship between obesity and the wide range of comorbidities, like type 2 diabetes mellitus, cardiovascular disease, etc., as diseases of the same etiopathology. Changing our lifestyle in accordance with our genetic makeup, including diet and physical activity, may help prevent or limit the development of these diseases.Keywords: diabetes, obesity, metabolic syndrome, insulin hypersecretion, oxidative stress, paleolithic diet, pathogenesis
format	article
author	Kopp W
author_facet	Kopp W
author_sort	Kopp W
title	How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
title_short	How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
title_full	How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
title_fullStr	How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
title_full_unstemmed	How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
title_sort	how western diet and lifestyle drive the pandemic of obesity and civilization diseases
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/748273d2951f4f6a9fad45b1b9da3033
work_keys_str_mv	AT koppw howwesterndietandlifestyledrivethepandemicofobesityandcivilizationdiseases
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How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases

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