Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer

Purpose: Many studies identified that the preoperative neutrophil-to-lymphocyte ratio (PNLR) was associated with patient prognosis in non-muscle-invasive bladder cancer (NMIBC). We hypothesized that PNLR could be prognostic in patients with histological variants of NMIBC (VH-NMIBC). Materials and M...

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Autores principales:	Deng-xiong Li, Xiao-ming Wang, Yin Tang, Yu-bo Yang, De-chao Feng, Ao Li, Fa-cai Zhang, Yun-jin Bai, Ping Han
Formato:	article
Lenguaje:	EN
Publicado:	Korean Urological Association 2021
Materias:	bladder cancer histology lymphocyte neutrophil prognosis Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/7483ada899804b7c8b0a5f295531d87a
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spelling	oai:doaj.org-article:7483ada899804b7c8b0a5f295531d87a2021-11-10T04:25:30ZPrognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer10.4111/icu.202102782466-04932466-054Xhttps://doaj.org/article/7483ada899804b7c8b0a5f295531d87a2021-11-01T00:00:00Zhttps://icurology.org/pdf/10.4111/icu.20210278https://doaj.org/toc/2466-0493https://doaj.org/toc/2466-054XPurpose: Many studies identified that the preoperative neutrophil-to-lymphocyte ratio (PNLR) was associated with patient prognosis in non-muscle-invasive bladder cancer (NMIBC). We hypothesized that PNLR could be prognostic in patients with histological variants of NMIBC (VH-NMIBC). Materials and Methods: This retrospective study included patients with VH-NMIBC admitted at our center between January 2009 and May 2019. The best cut-off value of NLR was measured by the receiver operating characteristic curve and Youden index. The Kaplan-Meier method and Cox proportional hazard regression models were employed to evaluate the association between PNLR and disease prognosis, including recurrence-free survival (RFS), progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS). Results: A total of 243 patients with VH-NMIBC were enrolled in our study. According to the Kaplan-Meier method results, patients with PNLR ≥2.2 were associated with poor RFS (p<0.001), PFS (p<0.001), CSS (p<0.001), and OS (p<0.001). Multivariable analyses indicated that PNLR ≥ 2.2 was an independent prognostic factor of RFS (hazard ratio [HR], 2.11; 95% confidence interval [CI, 1.57–1.83; p<0.001), PFS (HR, 2.34; 95% CI, 1.70–3.21; p<0.001), CCS (HR, 2.87; 95% CI, 1.96–4.18; p< 0.001), and OS (HR, 2.83; 95% CI, 1.96–4.07; p<0.001). Conclusions: This study identified that PNLR ≥2.2 was usually associated with a poor prognosis for patients with VH-NMIBC.Deng-xiong LiXiao-ming WangYin TangYu-bo YangDe-chao FengAo LiFa-cai ZhangYun-jin BaiPing HanKorean Urological Associationarticlebladder cancerhistologylymphocyteneutrophilprognosisDiseases of the genitourinary system. UrologyRC870-923ENInvestigative and Clinical Urology, Vol 62, Iss 6, Pp 641-649 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bladder cancer histology lymphocyte neutrophil prognosis Diseases of the genitourinary system. Urology RC870-923
spellingShingle	bladder cancer histology lymphocyte neutrophil prognosis Diseases of the genitourinary system. Urology RC870-923 Deng-xiong Li Xiao-ming Wang Yin Tang Yu-bo Yang De-chao Feng Ao Li Fa-cai Zhang Yun-jin Bai Ping Han Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer
description	Purpose: Many studies identified that the preoperative neutrophil-to-lymphocyte ratio (PNLR) was associated with patient prognosis in non-muscle-invasive bladder cancer (NMIBC). We hypothesized that PNLR could be prognostic in patients with histological variants of NMIBC (VH-NMIBC). Materials and Methods: This retrospective study included patients with VH-NMIBC admitted at our center between January 2009 and May 2019. The best cut-off value of NLR was measured by the receiver operating characteristic curve and Youden index. The Kaplan-Meier method and Cox proportional hazard regression models were employed to evaluate the association between PNLR and disease prognosis, including recurrence-free survival (RFS), progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS). Results: A total of 243 patients with VH-NMIBC were enrolled in our study. According to the Kaplan-Meier method results, patients with PNLR ≥2.2 were associated with poor RFS (p<0.001), PFS (p<0.001), CSS (p<0.001), and OS (p<0.001). Multivariable analyses indicated that PNLR ≥ 2.2 was an independent prognostic factor of RFS (hazard ratio [HR], 2.11; 95% confidence interval [CI, 1.57–1.83; p<0.001), PFS (HR, 2.34; 95% CI, 1.70–3.21; p<0.001), CCS (HR, 2.87; 95% CI, 1.96–4.18; p< 0.001), and OS (HR, 2.83; 95% CI, 1.96–4.07; p<0.001). Conclusions: This study identified that PNLR ≥2.2 was usually associated with a poor prognosis for patients with VH-NMIBC.
format	article
author	Deng-xiong Li Xiao-ming Wang Yin Tang Yu-bo Yang De-chao Feng Ao Li Fa-cai Zhang Yun-jin Bai Ping Han
author_facet	Deng-xiong Li Xiao-ming Wang Yin Tang Yu-bo Yang De-chao Feng Ao Li Fa-cai Zhang Yun-jin Bai Ping Han
author_sort	Deng-xiong Li
title	Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer
title_short	Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer
title_full	Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer
title_fullStr	Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer
title_full_unstemmed	Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer
title_sort	prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer
publisher	Korean Urological Association
publishDate	2021
url	https://doaj.org/article/7483ada899804b7c8b0a5f295531d87a
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Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer

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