Heimdallarchaea encodes profilin with eukaryotic-like actin regulation and polyproline binding

Chi and coworkers characterise proteins of Heimdallarchaeeota LC3, a member of the Asgard super phylum, and specifically investigate heim-Profilin and heim-Actin, and their interactions with polyproline and phospholipids. They also determine the 3D-structure of Heimdallarchaeota LC3 profilin. Their...

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Autores principales: Sabeen Survery, Fredrik Hurtig, Syed Razaul Haq, Jens Eriksson, Lionel Guy, K. Johan Rosengren, Ann-Christin Lindås, Celestine N. Chi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/748467ba73d04fdf9e54fc72819537ab
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Sumario:Chi and coworkers characterise proteins of Heimdallarchaeeota LC3, a member of the Asgard super phylum, and specifically investigate heim-Profilin and heim-Actin, and their interactions with polyproline and phospholipids. They also determine the 3D-structure of Heimdallarchaeota LC3 profilin. Their results suggest that a complex cytoskeleton existed in the last eukaryotic common ancestor indicating an origin predating the rise of the eukaryotes.