Increased DNA methylation variability in type 1 diabetes across three immune effector cell types
The incidence of type 1 diabetes is increasing, potentially implicating non-genetic factors. Here the authors conduct an epigenome-wide association study in disease-discordant twins and find increased DNA methylation variability at genes associated with immune cell metabolism and the cell cycle.
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/74847440186d44ba8513e31e9862b708 |
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oai:doaj.org-article:74847440186d44ba8513e31e9862b7082021-12-02T14:39:14ZIncreased DNA methylation variability in type 1 diabetes across three immune effector cell types10.1038/ncomms135552041-1723https://doaj.org/article/74847440186d44ba8513e31e9862b7082016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13555https://doaj.org/toc/2041-1723The incidence of type 1 diabetes is increasing, potentially implicating non-genetic factors. Here the authors conduct an epigenome-wide association study in disease-discordant twins and find increased DNA methylation variability at genes associated with immune cell metabolism and the cell cycle.Dirk S. PaulAndrew E. TeschendorffMary A.N. DangRobert LoweMohammed I. HawaSimone EckerHuriya BeyanStephanie CunninghamAlexandra R. FoutsAnita RameliusFrances BurdenSamantha FarrowSophia RowlstonKarola RehnstromMattia FrontiniKate DownesStephan BuscheWarren A. CheungBing GeMarie-Michelle SimonDavid BujoldTony KwanGuillaume BourqueAvik DattaErnesto LowyLaura ClarkePaul FlicekEmanuele LibertiniSimon HeathMarta GutIvo G GutWillem H. OuwehandTomi PastinenNicole SoranzoSabine E. HoferBeate KargesThomas MeissnerBernhard O. BoehmCorrado CilioHelena Elding LarssonÅke LernmarkAndrea K. SteckVardhman K. RakyanStephan BeckR. David LeslieNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
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DOAJ |
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EN |
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Science Q |
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Science Q Dirk S. Paul Andrew E. Teschendorff Mary A.N. Dang Robert Lowe Mohammed I. Hawa Simone Ecker Huriya Beyan Stephanie Cunningham Alexandra R. Fouts Anita Ramelius Frances Burden Samantha Farrow Sophia Rowlston Karola Rehnstrom Mattia Frontini Kate Downes Stephan Busche Warren A. Cheung Bing Ge Marie-Michelle Simon David Bujold Tony Kwan Guillaume Bourque Avik Datta Ernesto Lowy Laura Clarke Paul Flicek Emanuele Libertini Simon Heath Marta Gut Ivo G Gut Willem H. Ouwehand Tomi Pastinen Nicole Soranzo Sabine E. Hofer Beate Karges Thomas Meissner Bernhard O. Boehm Corrado Cilio Helena Elding Larsson Åke Lernmark Andrea K. Steck Vardhman K. Rakyan Stephan Beck R. David Leslie Increased DNA methylation variability in type 1 diabetes across three immune effector cell types |
| description |
The incidence of type 1 diabetes is increasing, potentially implicating non-genetic factors. Here the authors conduct an epigenome-wide association study in disease-discordant twins and find increased DNA methylation variability at genes associated with immune cell metabolism and the cell cycle. |
| format |
article |
| author |
Dirk S. Paul Andrew E. Teschendorff Mary A.N. Dang Robert Lowe Mohammed I. Hawa Simone Ecker Huriya Beyan Stephanie Cunningham Alexandra R. Fouts Anita Ramelius Frances Burden Samantha Farrow Sophia Rowlston Karola Rehnstrom Mattia Frontini Kate Downes Stephan Busche Warren A. Cheung Bing Ge Marie-Michelle Simon David Bujold Tony Kwan Guillaume Bourque Avik Datta Ernesto Lowy Laura Clarke Paul Flicek Emanuele Libertini Simon Heath Marta Gut Ivo G Gut Willem H. Ouwehand Tomi Pastinen Nicole Soranzo Sabine E. Hofer Beate Karges Thomas Meissner Bernhard O. Boehm Corrado Cilio Helena Elding Larsson Åke Lernmark Andrea K. Steck Vardhman K. Rakyan Stephan Beck R. David Leslie |
| author_facet |
Dirk S. Paul Andrew E. Teschendorff Mary A.N. Dang Robert Lowe Mohammed I. Hawa Simone Ecker Huriya Beyan Stephanie Cunningham Alexandra R. Fouts Anita Ramelius Frances Burden Samantha Farrow Sophia Rowlston Karola Rehnstrom Mattia Frontini Kate Downes Stephan Busche Warren A. Cheung Bing Ge Marie-Michelle Simon David Bujold Tony Kwan Guillaume Bourque Avik Datta Ernesto Lowy Laura Clarke Paul Flicek Emanuele Libertini Simon Heath Marta Gut Ivo G Gut Willem H. Ouwehand Tomi Pastinen Nicole Soranzo Sabine E. Hofer Beate Karges Thomas Meissner Bernhard O. Boehm Corrado Cilio Helena Elding Larsson Åke Lernmark Andrea K. Steck Vardhman K. Rakyan Stephan Beck R. David Leslie |
| author_sort |
Dirk S. Paul |
| title |
Increased DNA methylation variability in type 1 diabetes across three immune effector cell types |
| title_short |
Increased DNA methylation variability in type 1 diabetes across three immune effector cell types |
| title_full |
Increased DNA methylation variability in type 1 diabetes across three immune effector cell types |
| title_fullStr |
Increased DNA methylation variability in type 1 diabetes across three immune effector cell types |
| title_full_unstemmed |
Increased DNA methylation variability in type 1 diabetes across three immune effector cell types |
| title_sort |
increased dna methylation variability in type 1 diabetes across three immune effector cell types |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/74847440186d44ba8513e31e9862b708 |
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