A single-chain antibody generation system yielding CAR-T cells with superior antitumor function

With the aim of optimizing CAR-T cells for immunotherapy, Ochi et al. have established a system to generate and screen a library of CAR-T cells expressing different immunoglobulin variable regions. They show that this approach can enhance anti-tumour activities of CAR-T cells in vivo.

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Autores principales:	Toshiki Ochi, Masaki Maruta, Kazushi Tanimoto, Fumitake Kondo, Toshihiro Yamamoto, Mie Kurata, Hiroshi Fujiwara, Junya Masumoto, Katsuto Takenaka, Masaki Yasukawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7485112821794b669a860dcd7c69ca80
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spelling	oai:doaj.org-article:7485112821794b669a860dcd7c69ca802021-12-02T13:19:20ZA single-chain antibody generation system yielding CAR-T cells with superior antitumor function10.1038/s42003-021-01791-12399-3642https://doaj.org/article/7485112821794b669a860dcd7c69ca802021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01791-1https://doaj.org/toc/2399-3642With the aim of optimizing CAR-T cells for immunotherapy, Ochi et al. have established a system to generate and screen a library of CAR-T cells expressing different immunoglobulin variable regions. They show that this approach can enhance anti-tumour activities of CAR-T cells in vivo.Toshiki OchiMasaki MarutaKazushi TanimotoFumitake KondoToshihiro YamamotoMie KurataHiroshi FujiwaraJunya MasumotoKatsuto TakenakaMasaki YasukawaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Toshiki Ochi Masaki Maruta Kazushi Tanimoto Fumitake Kondo Toshihiro Yamamoto Mie Kurata Hiroshi Fujiwara Junya Masumoto Katsuto Takenaka Masaki Yasukawa A single-chain antibody generation system yielding CAR-T cells with superior antitumor function
description	With the aim of optimizing CAR-T cells for immunotherapy, Ochi et al. have established a system to generate and screen a library of CAR-T cells expressing different immunoglobulin variable regions. They show that this approach can enhance anti-tumour activities of CAR-T cells in vivo.
format	article
author	Toshiki Ochi Masaki Maruta Kazushi Tanimoto Fumitake Kondo Toshihiro Yamamoto Mie Kurata Hiroshi Fujiwara Junya Masumoto Katsuto Takenaka Masaki Yasukawa
author_facet	Toshiki Ochi Masaki Maruta Kazushi Tanimoto Fumitake Kondo Toshihiro Yamamoto Mie Kurata Hiroshi Fujiwara Junya Masumoto Katsuto Takenaka Masaki Yasukawa
author_sort	Toshiki Ochi
title	A single-chain antibody generation system yielding CAR-T cells with superior antitumor function
title_short	A single-chain antibody generation system yielding CAR-T cells with superior antitumor function
title_full	A single-chain antibody generation system yielding CAR-T cells with superior antitumor function
title_fullStr	A single-chain antibody generation system yielding CAR-T cells with superior antitumor function
title_full_unstemmed	A single-chain antibody generation system yielding CAR-T cells with superior antitumor function
title_sort	single-chain antibody generation system yielding car-t cells with superior antitumor function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7485112821794b669a860dcd7c69ca80
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A single-chain antibody generation system yielding CAR-T cells with superior antitumor function

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