Risk Factors of Influenza-Associated Respiratory Illnesses Reported to a Sentinel Hospital of Lahore, Pakistan: 2015-2016

Epidemiological data about determinants of influenza A virus (IAV) in the Pakistani population is scarce. We aimed to conduct a prospective hospital-based active surveillance study from October 2015 to May 2016 to identify potential risk factors associated with IAV infection among patients with infl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Saima Hasan, Muhammad Iqbal, Richard J. Webby, Jennifer DeBeauchamp, Hamad Bin Rashid, Mansur-ud-Din Ahmad, Jawad Nazir, Shakera Sadiq, Abdul Waheed Khan, Mamoona Chaudhry
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Infectious and parasitic diseases RC109-216 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7487b2e285ee4e79b7abea2ff1ebe2ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7487b2e285ee4e79b7abea2ff1ebe2ba
record_format	dspace
spelling	oai:doaj.org-article:7487b2e285ee4e79b7abea2ff1ebe2ba2021-11-08T02:35:38ZRisk Factors of Influenza-Associated Respiratory Illnesses Reported to a Sentinel Hospital of Lahore, Pakistan: 2015-20161918-149310.1155/2021/2460553https://doaj.org/article/7487b2e285ee4e79b7abea2ff1ebe2ba2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2460553https://doaj.org/toc/1918-1493Epidemiological data about determinants of influenza A virus (IAV) in the Pakistani population is scarce. We aimed to conduct a prospective hospital-based active surveillance study from October 2015 to May 2016 to identify potential risk factors associated with IAV infection among patients with influenza-like illness (ILI) and severe acute respiratory illness (SARI). Surveillance was conducted in Lahore General Hospital, selected as a sentinel site in Lahore District, Pakistan. Nasal/throat samples were collected along with epidemiological and clinical data from enrolled patients. Real-time reverse-transcription polymerase chain reaction (rRT-PCR) was performed to identify IAV and its subtypes (H1N1pdm09, H3N2). Data were analyzed to determine risk factors and risk markers associated with IAV infections. A total of 311 suspected ILI and SARI cases were enrolled in the study, and among these 50 were IAV-positive. Of these 50 confirmed cases of IAV, 14 were subtyped as H1N1pdm09 and 15 were H3N2; the remaining 21 were untyped. A final multivariable model identified four independent risk factors/markers for IAV infection: exposure history to ILI patients within last 7 days and gender being male were identified as risk factors of IAV infection, while use of antibiotics prior to hospital consultation and presence of fever were identified as risk markers. We concluded that adopting nonpharmaceutical interventions like hand hygiene, masks, social distancing, and where possible, avoiding identified risk factors could decrease the risk of IAV infection and may prevent imminent outbreaks of IAV in the community.Saima HasanMuhammad IqbalRichard J. WebbyJennifer DeBeauchampHamad Bin RashidMansur-ud-Din AhmadJawad NazirShakera SadiqAbdul Waheed KhanMamoona ChaudhryHindawi LimitedarticleInfectious and parasitic diseasesRC109-216MicrobiologyQR1-502ENCanadian Journal of Infectious Diseases and Medical Microbiology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Microbiology QR1-502
spellingShingle	Infectious and parasitic diseases RC109-216 Microbiology QR1-502 Saima Hasan Muhammad Iqbal Richard J. Webby Jennifer DeBeauchamp Hamad Bin Rashid Mansur-ud-Din Ahmad Jawad Nazir Shakera Sadiq Abdul Waheed Khan Mamoona Chaudhry Risk Factors of Influenza-Associated Respiratory Illnesses Reported to a Sentinel Hospital of Lahore, Pakistan: 2015-2016
description	Epidemiological data about determinants of influenza A virus (IAV) in the Pakistani population is scarce. We aimed to conduct a prospective hospital-based active surveillance study from October 2015 to May 2016 to identify potential risk factors associated with IAV infection among patients with influenza-like illness (ILI) and severe acute respiratory illness (SARI). Surveillance was conducted in Lahore General Hospital, selected as a sentinel site in Lahore District, Pakistan. Nasal/throat samples were collected along with epidemiological and clinical data from enrolled patients. Real-time reverse-transcription polymerase chain reaction (rRT-PCR) was performed to identify IAV and its subtypes (H1N1pdm09, H3N2). Data were analyzed to determine risk factors and risk markers associated with IAV infections. A total of 311 suspected ILI and SARI cases were enrolled in the study, and among these 50 were IAV-positive. Of these 50 confirmed cases of IAV, 14 were subtyped as H1N1pdm09 and 15 were H3N2; the remaining 21 were untyped. A final multivariable model identified four independent risk factors/markers for IAV infection: exposure history to ILI patients within last 7 days and gender being male were identified as risk factors of IAV infection, while use of antibiotics prior to hospital consultation and presence of fever were identified as risk markers. We concluded that adopting nonpharmaceutical interventions like hand hygiene, masks, social distancing, and where possible, avoiding identified risk factors could decrease the risk of IAV infection and may prevent imminent outbreaks of IAV in the community.
format	article
author	Saima Hasan Muhammad Iqbal Richard J. Webby Jennifer DeBeauchamp Hamad Bin Rashid Mansur-ud-Din Ahmad Jawad Nazir Shakera Sadiq Abdul Waheed Khan Mamoona Chaudhry
author_facet	Saima Hasan Muhammad Iqbal Richard J. Webby Jennifer DeBeauchamp Hamad Bin Rashid Mansur-ud-Din Ahmad Jawad Nazir Shakera Sadiq Abdul Waheed Khan Mamoona Chaudhry
author_sort	Saima Hasan
title	Risk Factors of Influenza-Associated Respiratory Illnesses Reported to a Sentinel Hospital of Lahore, Pakistan: 2015-2016
title_short	Risk Factors of Influenza-Associated Respiratory Illnesses Reported to a Sentinel Hospital of Lahore, Pakistan: 2015-2016
title_full	Risk Factors of Influenza-Associated Respiratory Illnesses Reported to a Sentinel Hospital of Lahore, Pakistan: 2015-2016
title_fullStr	Risk Factors of Influenza-Associated Respiratory Illnesses Reported to a Sentinel Hospital of Lahore, Pakistan: 2015-2016
title_full_unstemmed	Risk Factors of Influenza-Associated Respiratory Illnesses Reported to a Sentinel Hospital of Lahore, Pakistan: 2015-2016
title_sort	risk factors of influenza-associated respiratory illnesses reported to a sentinel hospital of lahore, pakistan: 2015-2016
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/7487b2e285ee4e79b7abea2ff1ebe2ba
work_keys_str_mv	AT saimahasan riskfactorsofinfluenzaassociatedrespiratoryillnessesreportedtoasentinelhospitaloflahorepakistan20152016 AT muhammadiqbal riskfactorsofinfluenzaassociatedrespiratoryillnessesreportedtoasentinelhospitaloflahorepakistan20152016 AT richardjwebby riskfactorsofinfluenzaassociatedrespiratoryillnessesreportedtoasentinelhospitaloflahorepakistan20152016 AT jenniferdebeauchamp riskfactorsofinfluenzaassociatedrespiratoryillnessesreportedtoasentinelhospitaloflahorepakistan20152016 AT hamadbinrashid riskfactorsofinfluenzaassociatedrespiratoryillnessesreportedtoasentinelhospitaloflahorepakistan20152016 AT mansuruddinahmad riskfactorsofinfluenzaassociatedrespiratoryillnessesreportedtoasentinelhospitaloflahorepakistan20152016 AT jawadnazir riskfactorsofinfluenzaassociatedrespiratoryillnessesreportedtoasentinelhospitaloflahorepakistan20152016 AT shakerasadiq riskfactorsofinfluenzaassociatedrespiratoryillnessesreportedtoasentinelhospitaloflahorepakistan20152016 AT abdulwaheedkhan riskfactorsofinfluenzaassociatedrespiratoryillnessesreportedtoasentinelhospitaloflahorepakistan20152016 AT mamoonachaudhry riskfactorsofinfluenzaassociatedrespiratoryillnessesreportedtoasentinelhospitaloflahorepakistan20152016
_version_	1718443196522954752

Risk Factors of Influenza-Associated Respiratory Illnesses Reported to a Sentinel Hospital of Lahore, Pakistan: 2015-2016

Ejemplares similares