Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD

Abstract STARS-Adjunct was a multicenter, open-label effectiveness study of AKL-T01, an app and video-game-based treatment for inattention, as an adjunct to pharmacotherapy in 8–14-year-old children with attention-deficit/hyperactivity disorder (ADHD) on stimulant medication (n = 130) or not on any...

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Autores principales:	Scott H. Kollins, Ann Childress, Andrew C. Heusser, Jacqueline Lutz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Computer applications to medicine. Medical informatics R858-859.7
Acceso en línea:	https://doaj.org/article/7488369121eb42569b73133dbbf7a64f
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spelling	oai:doaj.org-article:7488369121eb42569b73133dbbf7a64f2021-12-02T17:04:08ZEffectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD10.1038/s41746-021-00429-02398-6352https://doaj.org/article/7488369121eb42569b73133dbbf7a64f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41746-021-00429-0https://doaj.org/toc/2398-6352Abstract STARS-Adjunct was a multicenter, open-label effectiveness study of AKL-T01, an app and video-game-based treatment for inattention, as an adjunct to pharmacotherapy in 8–14-year-old children with attention-deficit/hyperactivity disorder (ADHD) on stimulant medication (n = 130) or not on any ADHD medication (n = 76). Children used AKL-T01 for 4 weeks, followed by a 4-week pause and another 4-week treatment. The primary outcome was change in ADHD-related impairment (Impairment Rating Scale (IRS)) after 4 weeks. Secondary outcomes included changes in IRS, ADHD Rating Scale (ADHD-RS). and Clinical Global Impressions Scale—Improvement (CGI-I) on days 28, 56, and 84. IRS significantly improved in both cohorts (On Stimulants: −0.7, p < 0.001; No Stimulants: −0.5, p < 0.001) after 4 weeks. IRS, ADHD-RS, and CGI-I remained stable during the pause and improved with a second treatment period. The treatment was well-tolerated with no serious adverse events. STARS-Adjunct extends AKL-T01’s body of evidence to a medication-treated pediatric ADHD population, and suggests additional treatment benefit.Scott H. KollinsAnn ChildressAndrew C. HeusserJacqueline LutzNature PortfolioarticleComputer applications to medicine. Medical informaticsR858-859.7ENnpj Digital Medicine, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Computer applications to medicine. Medical informatics R858-859.7
spellingShingle	Computer applications to medicine. Medical informatics R858-859.7 Scott H. Kollins Ann Childress Andrew C. Heusser Jacqueline Lutz Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD
description	Abstract STARS-Adjunct was a multicenter, open-label effectiveness study of AKL-T01, an app and video-game-based treatment for inattention, as an adjunct to pharmacotherapy in 8–14-year-old children with attention-deficit/hyperactivity disorder (ADHD) on stimulant medication (n = 130) or not on any ADHD medication (n = 76). Children used AKL-T01 for 4 weeks, followed by a 4-week pause and another 4-week treatment. The primary outcome was change in ADHD-related impairment (Impairment Rating Scale (IRS)) after 4 weeks. Secondary outcomes included changes in IRS, ADHD Rating Scale (ADHD-RS). and Clinical Global Impressions Scale—Improvement (CGI-I) on days 28, 56, and 84. IRS significantly improved in both cohorts (On Stimulants: −0.7, p < 0.001; No Stimulants: −0.5, p < 0.001) after 4 weeks. IRS, ADHD-RS, and CGI-I remained stable during the pause and improved with a second treatment period. The treatment was well-tolerated with no serious adverse events. STARS-Adjunct extends AKL-T01’s body of evidence to a medication-treated pediatric ADHD population, and suggests additional treatment benefit.
format	article
author	Scott H. Kollins Ann Childress Andrew C. Heusser Jacqueline Lutz
author_facet	Scott H. Kollins Ann Childress Andrew C. Heusser Jacqueline Lutz
author_sort	Scott H. Kollins
title	Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD
title_short	Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD
title_full	Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD
title_fullStr	Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD
title_full_unstemmed	Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD
title_sort	effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric adhd
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7488369121eb42569b73133dbbf7a64f
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Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD

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