REVIEW: POTENTIAL OF RED BETEL LEAVES (Piper crocatum) AS ANTI-INFLAMMATORY IN Rheumatoid Arthritis

Indonesia is a country with fertile soil and rich in plant species. Currently in society the use of medicinal plants as herbal treatment has increased. Elderly people often experience Rheumatoid Arthritis, which is inflammation of the synovial lining of the joints. One of the plants used by the com...

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Autores principales:	Novia Misnawati Aisyiyah, Khalish Arsy Al Khairy Siregar, Paula Mariana Kustiawan
Formato:	article
Lenguaje:	ID
Publicado:	Universitas Muhammadiyah Magelang 2021
Materias:	Antiinflammation Brazilin Flavonoid Piper crocatum Rheumatoid Arthritis Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/7488675c837c43ec84f823c3e84ceb19
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spelling	oai:doaj.org-article:7488675c837c43ec84f823c3e84ceb192021-12-01T09:52:49ZREVIEW: POTENTIAL OF RED BETEL LEAVES (Piper crocatum) AS ANTI-INFLAMMATORY IN Rheumatoid Arthritis10.31603/pharmacy.v7i2.52832549-90682579-4558https://doaj.org/article/7488675c837c43ec84f823c3e84ceb192021-12-01T00:00:00Zhttps://journal.unimma.ac.id/index.php/pharmacy/article/view/5283https://doaj.org/toc/2549-9068https://doaj.org/toc/2579-4558 Indonesia is a country with fertile soil and rich in plant species. Currently in society the use of medicinal plants as herbal treatment has increased. Elderly people often experience Rheumatoid Arthritis, which is inflammation of the synovial lining of the joints. One of the plants used by the community is red betel leaf (Piper crocatum). However, scientific information related to the potential of red betel as an anti-inflammatory in Rheumatoid Arthritis is still not widely known by the public. This study was conducted to explore the potential of P. crocatum leaves to treat Rheumatoid Arthritis which can be used as references regarding Rheumatoid Arthritis therapy. This study uses a narrative review method from previous studies that were collected related to the topic which was then discussed systematically. By using keywords in the search for Piper crocatum, anti-inflammatory activity, red betel bioactivity, secondary compounds in red betel leaf, and Rheumatoid Arthritis. P. crocatum leaves contain various bioactive compounds. Flavonoids have activity as primary and secondary antioxidants. Flavonoid compounds such as brazilien, brazilin, taxifolin, procyanidin found in red betel have anti-inflammatory activity in rheumatoid arthritis. Brazilin is one of the flavonoid compounds from P. crocatum leaves that has the potential as an anti-inflammatory in rheumatoid arthritis by regulating the transcription factor nuclear factor kappa B (NF-kB) for TNF- expression against inflammation. Novia Misnawati AisyiyahKhalish Arsy Al Khairy SiregarPaula Mariana KustiawanUniversitas Muhammadiyah MagelangarticleAntiinflammationBrazilinFlavonoidPiper crocatumRheumatoid ArthritisMedicineRPharmacy and materia medicaRS1-441IDJurnal Farmasi Sains dan Praktis, Vol 7, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	ID
topic	Antiinflammation Brazilin Flavonoid Piper crocatum Rheumatoid Arthritis Medicine R Pharmacy and materia medica RS1-441
spellingShingle	Antiinflammation Brazilin Flavonoid Piper crocatum Rheumatoid Arthritis Medicine R Pharmacy and materia medica RS1-441 Novia Misnawati Aisyiyah Khalish Arsy Al Khairy Siregar Paula Mariana Kustiawan REVIEW: POTENTIAL OF RED BETEL LEAVES (Piper crocatum) AS ANTI-INFLAMMATORY IN Rheumatoid Arthritis
description	Indonesia is a country with fertile soil and rich in plant species. Currently in society the use of medicinal plants as herbal treatment has increased. Elderly people often experience Rheumatoid Arthritis, which is inflammation of the synovial lining of the joints. One of the plants used by the community is red betel leaf (Piper crocatum). However, scientific information related to the potential of red betel as an anti-inflammatory in Rheumatoid Arthritis is still not widely known by the public. This study was conducted to explore the potential of P. crocatum leaves to treat Rheumatoid Arthritis which can be used as references regarding Rheumatoid Arthritis therapy. This study uses a narrative review method from previous studies that were collected related to the topic which was then discussed systematically. By using keywords in the search for Piper crocatum, anti-inflammatory activity, red betel bioactivity, secondary compounds in red betel leaf, and Rheumatoid Arthritis. P. crocatum leaves contain various bioactive compounds. Flavonoids have activity as primary and secondary antioxidants. Flavonoid compounds such as brazilien, brazilin, taxifolin, procyanidin found in red betel have anti-inflammatory activity in rheumatoid arthritis. Brazilin is one of the flavonoid compounds from P. crocatum leaves that has the potential as an anti-inflammatory in rheumatoid arthritis by regulating the transcription factor nuclear factor kappa B (NF-kB) for TNF- expression against inflammation.
format	article
author	Novia Misnawati Aisyiyah Khalish Arsy Al Khairy Siregar Paula Mariana Kustiawan
author_facet	Novia Misnawati Aisyiyah Khalish Arsy Al Khairy Siregar Paula Mariana Kustiawan
author_sort	Novia Misnawati Aisyiyah
title	REVIEW: POTENTIAL OF RED BETEL LEAVES (Piper crocatum) AS ANTI-INFLAMMATORY IN Rheumatoid Arthritis
title_short	REVIEW: POTENTIAL OF RED BETEL LEAVES (Piper crocatum) AS ANTI-INFLAMMATORY IN Rheumatoid Arthritis
title_full	REVIEW: POTENTIAL OF RED BETEL LEAVES (Piper crocatum) AS ANTI-INFLAMMATORY IN Rheumatoid Arthritis
title_fullStr	REVIEW: POTENTIAL OF RED BETEL LEAVES (Piper crocatum) AS ANTI-INFLAMMATORY IN Rheumatoid Arthritis
title_full_unstemmed	REVIEW: POTENTIAL OF RED BETEL LEAVES (Piper crocatum) AS ANTI-INFLAMMATORY IN Rheumatoid Arthritis
title_sort	review: potential of red betel leaves (piper crocatum) as anti-inflammatory in rheumatoid arthritis
publisher	Universitas Muhammadiyah Magelang
publishDate	2021
url	https://doaj.org/article/7488675c837c43ec84f823c3e84ceb19
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REVIEW: POTENTIAL OF RED BETEL LEAVES (Piper crocatum) AS ANTI-INFLAMMATORY IN Rheumatoid Arthritis

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