Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis.

<h4>Background and purpose</h4>Patients with low estimated glomerular filtration rate (eGFR) and proteinuria may be at increased risk for stroke. This study investigated whether low eGFR and proteinuria are outcome predictors in stroke patients treated with intravenous thrombolysis.<h...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chih-Hao Chen, Sung-Chun Tang, Li-Kai Tsai, Shin-Joe Yeh, Kai-Hsiang Chen, Chen-Hua Li, Yu-Jen Hsiao, Yu-Wei Chen, Bak-Sau Yip, Jiann-Shing Jeng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/74890f948932472bbbc76cf86710e050
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:74890f948932472bbbc76cf86710e050
record_format	dspace
spelling	oai:doaj.org-article:74890f948932472bbbc76cf86710e0502021-11-18T08:45:02ZProteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis.1932-620310.1371/journal.pone.0080527https://doaj.org/article/74890f948932472bbbc76cf86710e0502013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278288/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and purpose</h4>Patients with low estimated glomerular filtration rate (eGFR) and proteinuria may be at increased risk for stroke. This study investigated whether low eGFR and proteinuria are outcome predictors in stroke patients treated with intravenous thrombolysis.<h4>Methods</h4>We studied 432 consecutive stroke patients who received thrombolysis from January 2006 to December 2012, in Taiwan. Unfavorable outcome was defined as modified Rankin scale ≥2 at 3 months after stroke. Proteinuria was classified as negative or trace, mild, and moderate to severe. Using logistic regression analysis, we identified independent factors for unfavorable outcome after thrombolysis.<h4>Results</h4>Of all patients, 32.7% had proteinuria. Patients with proteinuria were older, had higher frequencies of diabetes mellitus, hyperlipidemia, atrial fibrillation, lower eGFR, and greater severity of stroke upon admission than those without proteinuria. Proteinuria, not low eGFR, was an independent predictor for unfavorable outcome for stroke (OR = 2.00 for mild proteinuria, p = 0.035; OR = 2.54 for moderate to severe proteinuria, p = 0.035). However, no clear relationship was found between proteinuria and symptomatic hemorrhage after thrombolysis.<h4>Conclusions</h4>Proteinuria is an independent predictor of unfavorable outcome for acute ischemic stroke in patients treated with intravenous thrombolysis, indicating the crucial role of chronic kidney disease on the effectiveness of thrombolysis.Chih-Hao ChenSung-Chun TangLi-Kai TsaiShin-Joe YehKai-Hsiang ChenChen-Hua LiYu-Jen HsiaoYu-Wei ChenBak-Sau YipJiann-Shing JengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80527 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chih-Hao Chen Sung-Chun Tang Li-Kai Tsai Shin-Joe Yeh Kai-Hsiang Chen Chen-Hua Li Yu-Jen Hsiao Yu-Wei Chen Bak-Sau Yip Jiann-Shing Jeng Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis.
description	<h4>Background and purpose</h4>Patients with low estimated glomerular filtration rate (eGFR) and proteinuria may be at increased risk for stroke. This study investigated whether low eGFR and proteinuria are outcome predictors in stroke patients treated with intravenous thrombolysis.<h4>Methods</h4>We studied 432 consecutive stroke patients who received thrombolysis from January 2006 to December 2012, in Taiwan. Unfavorable outcome was defined as modified Rankin scale ≥2 at 3 months after stroke. Proteinuria was classified as negative or trace, mild, and moderate to severe. Using logistic regression analysis, we identified independent factors for unfavorable outcome after thrombolysis.<h4>Results</h4>Of all patients, 32.7% had proteinuria. Patients with proteinuria were older, had higher frequencies of diabetes mellitus, hyperlipidemia, atrial fibrillation, lower eGFR, and greater severity of stroke upon admission than those without proteinuria. Proteinuria, not low eGFR, was an independent predictor for unfavorable outcome for stroke (OR = 2.00 for mild proteinuria, p = 0.035; OR = 2.54 for moderate to severe proteinuria, p = 0.035). However, no clear relationship was found between proteinuria and symptomatic hemorrhage after thrombolysis.<h4>Conclusions</h4>Proteinuria is an independent predictor of unfavorable outcome for acute ischemic stroke in patients treated with intravenous thrombolysis, indicating the crucial role of chronic kidney disease on the effectiveness of thrombolysis.
format	article
author	Chih-Hao Chen Sung-Chun Tang Li-Kai Tsai Shin-Joe Yeh Kai-Hsiang Chen Chen-Hua Li Yu-Jen Hsiao Yu-Wei Chen Bak-Sau Yip Jiann-Shing Jeng
author_facet	Chih-Hao Chen Sung-Chun Tang Li-Kai Tsai Shin-Joe Yeh Kai-Hsiang Chen Chen-Hua Li Yu-Jen Hsiao Yu-Wei Chen Bak-Sau Yip Jiann-Shing Jeng
author_sort	Chih-Hao Chen
title	Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis.
title_short	Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis.
title_full	Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis.
title_fullStr	Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis.
title_full_unstemmed	Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis.
title_sort	proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/74890f948932472bbbc76cf86710e050
work_keys_str_mv	AT chihhaochen proteinuriaindependentlypredictsunfavorableoutcomeofischemicstrokepatientsreceivingintravenousthrombolysis AT sungchuntang proteinuriaindependentlypredictsunfavorableoutcomeofischemicstrokepatientsreceivingintravenousthrombolysis AT likaitsai proteinuriaindependentlypredictsunfavorableoutcomeofischemicstrokepatientsreceivingintravenousthrombolysis AT shinjoeyeh proteinuriaindependentlypredictsunfavorableoutcomeofischemicstrokepatientsreceivingintravenousthrombolysis AT kaihsiangchen proteinuriaindependentlypredictsunfavorableoutcomeofischemicstrokepatientsreceivingintravenousthrombolysis AT chenhuali proteinuriaindependentlypredictsunfavorableoutcomeofischemicstrokepatientsreceivingintravenousthrombolysis AT yujenhsiao proteinuriaindependentlypredictsunfavorableoutcomeofischemicstrokepatientsreceivingintravenousthrombolysis AT yuweichen proteinuriaindependentlypredictsunfavorableoutcomeofischemicstrokepatientsreceivingintravenousthrombolysis AT baksauyip proteinuriaindependentlypredictsunfavorableoutcomeofischemicstrokepatientsreceivingintravenousthrombolysis AT jiannshingjeng proteinuriaindependentlypredictsunfavorableoutcomeofischemicstrokepatientsreceivingintravenousthrombolysis
_version_	1718421389909688320

Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis.

Ejemplares similares