Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—A Population-Based Study
Background: The rates of missed gastric cancers (MGC) at upper endoscopy (UE) has been reported at 5–10% in Western countries. We aimed to calculate the rate of MGC and identify factors associated with MGC. Methods: Retrospective population-based cohort study including 730 patients diagnosed with ga...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/748afd276e3548b6a220ca6251b7365b |
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| Sumario: | Background: The rates of missed gastric cancers (MGC) at upper endoscopy (UE) has been reported at 5–10% in Western countries. We aimed to calculate the rate of MGC and identify factors associated with MGC. Methods: Retrospective population-based cohort study including 730 patients diagnosed with gastric adenocarcinoma in Central Norway 2007–2016. MGCs were incident gastric adenocarcinomas diagnosed 6–36 months after a previous UE. Factors associated with MGC were examined. Definitely missed (UE 6–12 months prior) and potentially missed (UE 12–36 months prior) MGCs were compared. Results: Sixty-seven (9.2%) of 730 gastric cancers were MGC. MGC were associated with localization (<i>p</i> = 0.009) and more frequent in the corpus, Lauren’s histological type (<i>p</i> = 0.028) and diffuse type more prevalent, and previous Billroth 2-operation (14.9% vs. 4.7%, <i>p</i> = 0.001). MGCs were diagnosed at earlier stages (<i>p</i> = 0.037). An ulceration was more common in patients with definitely missed than potentially MGC (40.9% vs. 17.8%, <i>p</i> = 0.041). Conclusions: MGC accounted for 9.2% of gastric cancers in Central Norway. MGC were associated with localization in the corpus, Lauren´s diffuse type and previous Billroth-2-operation. Intensified follow-up and adequate biopsy sampling of patients with gastric ulcerations could reduce the rate of missed gastric cancers. |
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