Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—A Population-Based Study

Background: The rates of missed gastric cancers (MGC) at upper endoscopy (UE) has been reported at 5–10% in Western countries. We aimed to calculate the rate of MGC and identify factors associated with MGC. Methods: Retrospective population-based cohort study including 730 patients diagnosed with ga...

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Autores principales:	Marianne Beck, Erling A. Bringeland, Gunnar Qvigstad, Reidar Fossmark
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gastric cancer missed cancer upper endoscopy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/748afd276e3548b6a220ca6251b7365b
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spelling	oai:doaj.org-article:748afd276e3548b6a220ca6251b7365b2021-11-25T17:01:49ZGastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—A Population-Based Study10.3390/cancers132256282072-6694https://doaj.org/article/748afd276e3548b6a220ca6251b7365b2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5628https://doaj.org/toc/2072-6694Background: The rates of missed gastric cancers (MGC) at upper endoscopy (UE) has been reported at 5–10% in Western countries. We aimed to calculate the rate of MGC and identify factors associated with MGC. Methods: Retrospective population-based cohort study including 730 patients diagnosed with gastric adenocarcinoma in Central Norway 2007–2016. MGCs were incident gastric adenocarcinomas diagnosed 6–36 months after a previous UE. Factors associated with MGC were examined. Definitely missed (UE 6–12 months prior) and potentially missed (UE 12–36 months prior) MGCs were compared. Results: Sixty-seven (9.2%) of 730 gastric cancers were MGC. MGC were associated with localization (<i>p</i> = 0.009) and more frequent in the corpus, Lauren’s histological type (<i>p</i> = 0.028) and diffuse type more prevalent, and previous Billroth 2-operation (14.9% vs. 4.7%, <i>p</i> = 0.001). MGCs were diagnosed at earlier stages (<i>p</i> = 0.037). An ulceration was more common in patients with definitely missed than potentially MGC (40.9% vs. 17.8%, <i>p</i> = 0.041). Conclusions: MGC accounted for 9.2% of gastric cancers in Central Norway. MGC were associated with localization in the corpus, Lauren´s diffuse type and previous Billroth-2-operation. Intensified follow-up and adequate biopsy sampling of patients with gastric ulcerations could reduce the rate of missed gastric cancers.Marianne BeckErling A. BringelandGunnar QvigstadReidar FossmarkMDPI AGarticlegastric cancermissed cancerupper endoscopyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5628, p 5628 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric cancer missed cancer upper endoscopy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	gastric cancer missed cancer upper endoscopy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Marianne Beck Erling A. Bringeland Gunnar Qvigstad Reidar Fossmark Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—A Population-Based Study
description	Background: The rates of missed gastric cancers (MGC) at upper endoscopy (UE) has been reported at 5–10% in Western countries. We aimed to calculate the rate of MGC and identify factors associated with MGC. Methods: Retrospective population-based cohort study including 730 patients diagnosed with gastric adenocarcinoma in Central Norway 2007–2016. MGCs were incident gastric adenocarcinomas diagnosed 6–36 months after a previous UE. Factors associated with MGC were examined. Definitely missed (UE 6–12 months prior) and potentially missed (UE 12–36 months prior) MGCs were compared. Results: Sixty-seven (9.2%) of 730 gastric cancers were MGC. MGC were associated with localization (<i>p</i> = 0.009) and more frequent in the corpus, Lauren’s histological type (<i>p</i> = 0.028) and diffuse type more prevalent, and previous Billroth 2-operation (14.9% vs. 4.7%, <i>p</i> = 0.001). MGCs were diagnosed at earlier stages (<i>p</i> = 0.037). An ulceration was more common in patients with definitely missed than potentially MGC (40.9% vs. 17.8%, <i>p</i> = 0.041). Conclusions: MGC accounted for 9.2% of gastric cancers in Central Norway. MGC were associated with localization in the corpus, Lauren´s diffuse type and previous Billroth-2-operation. Intensified follow-up and adequate biopsy sampling of patients with gastric ulcerations could reduce the rate of missed gastric cancers.
format	article
author	Marianne Beck Erling A. Bringeland Gunnar Qvigstad Reidar Fossmark
author_facet	Marianne Beck Erling A. Bringeland Gunnar Qvigstad Reidar Fossmark
author_sort	Marianne Beck
title	Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—A Population-Based Study
title_short	Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—A Population-Based Study
title_full	Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—A Population-Based Study
title_fullStr	Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—A Population-Based Study
title_full_unstemmed	Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—A Population-Based Study
title_sort	gastric cancers missed at upper endoscopy in central norway 2007 to 2016—a population-based study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/748afd276e3548b6a220ca6251b7365b
work_keys_str_mv	AT mariannebeck gastriccancersmissedatupperendoscopyincentralnorway2007to2016apopulationbasedstudy AT erlingabringeland gastriccancersmissedatupperendoscopyincentralnorway2007to2016apopulationbasedstudy AT gunnarqvigstad gastriccancersmissedatupperendoscopyincentralnorway2007to2016apopulationbasedstudy AT reidarfossmark gastriccancersmissedatupperendoscopyincentralnorway2007to2016apopulationbasedstudy
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Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—A Population-Based Study

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