Broad-Host-Range Expression Reveals Native and Host Regulatory Elements That Influence Heterologous Antibiotic Production in Gram-Negative Bacteria

ABSTRACT Heterologous expression has become a powerful tool for studying microbial biosynthetic gene clusters (BGCs). Here, we extend the transformation-associated recombination cloning and heterologous expression platform for microbial BGCs to include Gram-negative proteobacterial expression hosts....

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Bibliographic Details
Main Authors: Jia Jia Zhang, Xiaoyu Tang, Michelle Zhang, Darlene Nguyen, Bradley S. Moore
Format: article
Language:EN
Published: American Society for Microbiology 2017
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Online Access:https://doaj.org/article/748b1cccf587411e8ba73b0dbd938e30
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