Social cognitive training for adults with Noonan syndrome: a feasibility study

Renée L Roelofs,1,2 Ellen Wingbermühle,1,2 Roy PC Kessels,2–4 Jos IM Egger1–3,5 1Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands; 2Donders Institute for Brain, Cognition and Behaviour, Radboud Unive...

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Autores principales:	Roelofs RL, Wingbermühle E, Kessels RPC, Egger JIM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Noonan syndrome social cognition alexithymia cognition social cognitive training social cognitive intervention Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/748da2b5e47741f6922d229843fbe2ea
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spelling	oai:doaj.org-article:748da2b5e47741f6922d229843fbe2ea2021-12-02T05:37:27ZSocial cognitive training for adults with Noonan syndrome: a feasibility study1178-2021https://doaj.org/article/748da2b5e47741f6922d229843fbe2ea2019-02-01T00:00:00Zhttps://www.dovepress.com/social-cognitive-training-for-adults-with-noonan-syndrome-a-feasibilit-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Renée L Roelofs,1,2 Ellen Wingbermühle,1,2 Roy PC Kessels,2–4 Jos IM Egger1–3,5 1Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands; 2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands; 3Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands; 4Department of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands; 5Stevig Specialized and Forensic Care for Patients with Intellectual Disabilities, Dichterbij, Oostrum, The Netherlands Purpose: Noonan syndrome (NS) is a genetic disorder that is associated with social cognitive problems. While treatment aimed at the improvement of social cognition is available for other neuropsychiatric disorders, no such interventions yet exist for NS patients. In this study, the development of the first social cognitive training for NS patients is described and its applicability and feasibility evaluated. Methods: Eleven adult patients with NS participated in this controlled proof-of-principle study. Six patients were included in the treatment group and five in the control group. Neuropsychological testing was performed in both groups at baseline and posttreatment. Social cognition was a primary outcome measure and nonsocial cognition and psychopathology secondary outcome measures. Differences between pre- and posttest were investigated with Wilcoxon signed-rank tests, and a process evaluation was performed to aid interpretation of the results. Results: Both groups were comparable with regard to age, estimated intelligence, and baseline performance. Although no significant differences were found between pre- and posttest scores on primary and secondary outcome measures in either group, a medium–large effect size was found on emotion recognition in the treatment group. Also, the process evaluation demonstrated the feasibility of the training. Conclusion: This first social cognitive training for adult patients with NS has proven to be feasible for this population and showed some encouraging results regarding emotion recognition, although the training protocol could be optimized. Further investigation is required using a randomized controlled design in a larger sample, in order to substantiate the overall effectiveness of the training. Keywords: social cognition, alexithymia, cognition, social cognitive intervention, genetic syndromeRoelofs RLWingbermühle EKessels RPCEgger JIMDove Medical PressarticleNoonan syndromesocial cognitionalexithymiacognitionsocial cognitive trainingsocial cognitive interventionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 611-626 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Noonan syndrome social cognition alexithymia cognition social cognitive training social cognitive intervention Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Noonan syndrome social cognition alexithymia cognition social cognitive training social cognitive intervention Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Roelofs RL Wingbermühle E Kessels RPC Egger JIM Social cognitive training for adults with Noonan syndrome: a feasibility study
description	Renée L Roelofs,1,2 Ellen Wingbermühle,1,2 Roy PC Kessels,2–4 Jos IM Egger1–3,5 1Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands; 2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands; 3Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands; 4Department of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands; 5Stevig Specialized and Forensic Care for Patients with Intellectual Disabilities, Dichterbij, Oostrum, The Netherlands Purpose: Noonan syndrome (NS) is a genetic disorder that is associated with social cognitive problems. While treatment aimed at the improvement of social cognition is available for other neuropsychiatric disorders, no such interventions yet exist for NS patients. In this study, the development of the first social cognitive training for NS patients is described and its applicability and feasibility evaluated. Methods: Eleven adult patients with NS participated in this controlled proof-of-principle study. Six patients were included in the treatment group and five in the control group. Neuropsychological testing was performed in both groups at baseline and posttreatment. Social cognition was a primary outcome measure and nonsocial cognition and psychopathology secondary outcome measures. Differences between pre- and posttest were investigated with Wilcoxon signed-rank tests, and a process evaluation was performed to aid interpretation of the results. Results: Both groups were comparable with regard to age, estimated intelligence, and baseline performance. Although no significant differences were found between pre- and posttest scores on primary and secondary outcome measures in either group, a medium–large effect size was found on emotion recognition in the treatment group. Also, the process evaluation demonstrated the feasibility of the training. Conclusion: This first social cognitive training for adult patients with NS has proven to be feasible for this population and showed some encouraging results regarding emotion recognition, although the training protocol could be optimized. Further investigation is required using a randomized controlled design in a larger sample, in order to substantiate the overall effectiveness of the training. Keywords: social cognition, alexithymia, cognition, social cognitive intervention, genetic syndrome
format	article
author	Roelofs RL Wingbermühle E Kessels RPC Egger JIM
author_facet	Roelofs RL Wingbermühle E Kessels RPC Egger JIM
author_sort	Roelofs RL
title	Social cognitive training for adults with Noonan syndrome: a feasibility study
title_short	Social cognitive training for adults with Noonan syndrome: a feasibility study
title_full	Social cognitive training for adults with Noonan syndrome: a feasibility study
title_fullStr	Social cognitive training for adults with Noonan syndrome: a feasibility study
title_full_unstemmed	Social cognitive training for adults with Noonan syndrome: a feasibility study
title_sort	social cognitive training for adults with noonan syndrome: a feasibility study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/748da2b5e47741f6922d229843fbe2ea
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Social cognitive training for adults with Noonan syndrome: a feasibility study

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