Literature reviews of stroke with hypereosinophilic syndrome

Hypereosinophilic syndrome (HES) is defined by persistently elevated blood eosinophil levels and is associated with evidence of organ damage. Cardiovascular involvement in HES is most commonly associated with Loffler endocarditis (cardiac HES). Cardiac HES is typically characterized by progressive s...

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Autores principales:	Ryohei Ono, Togo Iwahana, Hirotoshi Kato, Sho Okada, Yoshio Kobayashi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Hypereosinophilic syndrome Loffler’s endocarditis Review Stroke Thrombosis Watershed infarcts Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/748e0b51fc0842f2a3594c9d7ffab0bc
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spelling	oai:doaj.org-article:748e0b51fc0842f2a3594c9d7ffab0bc2021-11-28T04:34:39ZLiterature reviews of stroke with hypereosinophilic syndrome2352-906710.1016/j.ijcha.2021.100915https://doaj.org/article/748e0b51fc0842f2a3594c9d7ffab0bc2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352906721002037https://doaj.org/toc/2352-9067Hypereosinophilic syndrome (HES) is defined by persistently elevated blood eosinophil levels and is associated with evidence of organ damage. Cardiovascular involvement in HES is most commonly associated with Loffler endocarditis (cardiac HES). Cardiac HES is typically characterized by progressive subendocardial fibrosis with overlying mural thrombus formation, leading to restrictive dysfunction of the left ventricle. The thrombus from cardiac HES could result in cardiogenic stroke; however, most of the stroke cases with HES were not associated with huge thromboembolism rather multiple infarcts in the watershed area. The major clinical features of 97 previously reported cases of stroke with HES are as follows: the median age was 52 years, of which 61 (63%) were men; the initial presenting symptoms were neurological (73%), followed by headache (16%), respiratory symptoms (9%), and visual symptoms (9%). Almost half of the cases were diagnosed with cardiac HES. The characteristics of cardiac findings were mural thrombi, endomyocardial fibrosis, and a restrictive pattern of heart failure. Cerebral findings revealed 78 cases (80%) were described as multiple infarctions and 55 cases (57 %) were involved with watershed areas, whereas 11 cases (11％) were described as embolic stroke for one proximal large-vessel occlusion. Regarding treatment, 71 (73%), 28 (29%), and 16 (16%) patients were treated with steroids, anticoagulants, and antiplatelets, respectively. The overall mortality and recovery rates were 11% and 89%, respectively. Physicians should know most cases of stroke with HES are characterized by multiple infarctions in the watershed area, and cardiac HES is not always associated with stroke.Ryohei OnoTogo IwahanaHirotoshi KatoSho OkadaYoshio KobayashiElsevierarticleHypereosinophilic syndromeLoffler’s endocarditisReviewStrokeThrombosisWatershed infarctsDiseases of the circulatory (Cardiovascular) systemRC666-701ENInternational Journal of Cardiology: Heart & Vasculature, Vol 37, Iss , Pp 100915- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hypereosinophilic syndrome Loffler’s endocarditis Review Stroke Thrombosis Watershed infarcts Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Hypereosinophilic syndrome Loffler’s endocarditis Review Stroke Thrombosis Watershed infarcts Diseases of the circulatory (Cardiovascular) system RC666-701 Ryohei Ono Togo Iwahana Hirotoshi Kato Sho Okada Yoshio Kobayashi Literature reviews of stroke with hypereosinophilic syndrome
description	Hypereosinophilic syndrome (HES) is defined by persistently elevated blood eosinophil levels and is associated with evidence of organ damage. Cardiovascular involvement in HES is most commonly associated with Loffler endocarditis (cardiac HES). Cardiac HES is typically characterized by progressive subendocardial fibrosis with overlying mural thrombus formation, leading to restrictive dysfunction of the left ventricle. The thrombus from cardiac HES could result in cardiogenic stroke; however, most of the stroke cases with HES were not associated with huge thromboembolism rather multiple infarcts in the watershed area. The major clinical features of 97 previously reported cases of stroke with HES are as follows: the median age was 52 years, of which 61 (63%) were men; the initial presenting symptoms were neurological (73%), followed by headache (16%), respiratory symptoms (9%), and visual symptoms (9%). Almost half of the cases were diagnosed with cardiac HES. The characteristics of cardiac findings were mural thrombi, endomyocardial fibrosis, and a restrictive pattern of heart failure. Cerebral findings revealed 78 cases (80%) were described as multiple infarctions and 55 cases (57 %) were involved with watershed areas, whereas 11 cases (11％) were described as embolic stroke for one proximal large-vessel occlusion. Regarding treatment, 71 (73%), 28 (29%), and 16 (16%) patients were treated with steroids, anticoagulants, and antiplatelets, respectively. The overall mortality and recovery rates were 11% and 89%, respectively. Physicians should know most cases of stroke with HES are characterized by multiple infarctions in the watershed area, and cardiac HES is not always associated with stroke.
format	article
author	Ryohei Ono Togo Iwahana Hirotoshi Kato Sho Okada Yoshio Kobayashi
author_facet	Ryohei Ono Togo Iwahana Hirotoshi Kato Sho Okada Yoshio Kobayashi
author_sort	Ryohei Ono
title	Literature reviews of stroke with hypereosinophilic syndrome
title_short	Literature reviews of stroke with hypereosinophilic syndrome
title_full	Literature reviews of stroke with hypereosinophilic syndrome
title_fullStr	Literature reviews of stroke with hypereosinophilic syndrome
title_full_unstemmed	Literature reviews of stroke with hypereosinophilic syndrome
title_sort	literature reviews of stroke with hypereosinophilic syndrome
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/748e0b51fc0842f2a3594c9d7ffab0bc
work_keys_str_mv	AT ryoheiono literaturereviewsofstrokewithhypereosinophilicsyndrome AT togoiwahana literaturereviewsofstrokewithhypereosinophilicsyndrome AT hirotoshikato literaturereviewsofstrokewithhypereosinophilicsyndrome AT shookada literaturereviewsofstrokewithhypereosinophilicsyndrome AT yoshiokobayashi literaturereviewsofstrokewithhypereosinophilicsyndrome
_version_	1718408324559405056

Literature reviews of stroke with hypereosinophilic syndrome

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