Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses

Humanized mice are an enabling technology to explore human immunity and disease. Here, Douam et al. provide an in-depth comparison of immune responses to yellow fever vaccine in human vaccinees, conventional and second-generation humanized mice and define a workflow to evaluate and refine these mode...

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Autores principales:	Florian Douam, Carly G. K. Ziegler, Gabriela Hrebikova, Bruno Fant, Robert Leach, Lance Parsons, Wei Wang, Jenna M. Gaska, Benjamin Y. Winer, Brigitte Heller, Alex K. Shalek, Alexander Ploss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74919627ccd0481f9143428c27498c08
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spelling	oai:doaj.org-article:74919627ccd0481f9143428c27498c082021-12-02T14:38:50ZSelective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses10.1038/s41467-018-07478-22041-1723https://doaj.org/article/74919627ccd0481f9143428c27498c082018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07478-2https://doaj.org/toc/2041-1723Humanized mice are an enabling technology to explore human immunity and disease. Here, Douam et al. provide an in-depth comparison of immune responses to yellow fever vaccine in human vaccinees, conventional and second-generation humanized mice and define a workflow to evaluate and refine these models.Florian DouamCarly G. K. ZieglerGabriela HrebikovaBruno FantRobert LeachLance ParsonsWei WangJenna M. GaskaBenjamin Y. WinerBrigitte HellerAlex K. ShalekAlexander PlossNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florian Douam Carly G. K. Ziegler Gabriela Hrebikova Bruno Fant Robert Leach Lance Parsons Wei Wang Jenna M. Gaska Benjamin Y. Winer Brigitte Heller Alex K. Shalek Alexander Ploss Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
description	Humanized mice are an enabling technology to explore human immunity and disease. Here, Douam et al. provide an in-depth comparison of immune responses to yellow fever vaccine in human vaccinees, conventional and second-generation humanized mice and define a workflow to evaluate and refine these models.
format	article
author	Florian Douam Carly G. K. Ziegler Gabriela Hrebikova Bruno Fant Robert Leach Lance Parsons Wei Wang Jenna M. Gaska Benjamin Y. Winer Brigitte Heller Alex K. Shalek Alexander Ploss
author_facet	Florian Douam Carly G. K. Ziegler Gabriela Hrebikova Bruno Fant Robert Leach Lance Parsons Wei Wang Jenna M. Gaska Benjamin Y. Winer Brigitte Heller Alex K. Shalek Alexander Ploss
author_sort	Florian Douam
title	Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
title_short	Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
title_full	Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
title_fullStr	Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
title_full_unstemmed	Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
title_sort	selective expansion of myeloid and nk cells in humanized mice yields human-like vaccine responses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/74919627ccd0481f9143428c27498c08
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Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses

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