Transcranial light-emitting diode therapy for neuropsychological improvement after traumatic brain injury: a new perspective for diffuse axonal lesion management

João Gustavo Rocha Peixoto dos Santos, Wellingson Silva Paiva, Manoel Jacobsen Teixeira Department of Neurological Surgery, University of São Paulo School of Medicine, São Paulo, Brazil Abstract: The cost of traumatic brain injury (TBI) for public health policies is...

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Autores principales:	Santos JG, Paiva WS, Teixeira MJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Brain Injuries Traumatic;Diffuse Axonal Injury;Low-Level Light Therapy;Neurologic Manifestations;Post-Concussion Syndrome;Quality of Life. Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/7493898871924f6f8440aad7c0634d1b
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spelling	oai:doaj.org-article:7493898871924f6f8440aad7c0634d1b2021-12-02T00:43:02ZTranscranial light-emitting diode therapy for neuropsychological improvement after traumatic brain injury: a new perspective for diffuse axonal lesion management1179-1470https://doaj.org/article/7493898871924f6f8440aad7c0634d1b2018-04-01T00:00:00Zhttps://www.dovepress.com/transcranial-light-emitting-diode-therapy-for-neuropsychological-impro-peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470João Gustavo Rocha Peixoto dos Santos, Wellingson Silva Paiva, Manoel Jacobsen Teixeira Department of Neurological Surgery, University of São Paulo School of Medicine, São Paulo, Brazil Abstract: The cost of traumatic brain injury (TBI) for public health policies is undeniable today. Even patients who suffer from mild TBI may persist with cognitive symptoms weeks after the accident. Most of them show no lesion in computed tomography or conventional magnetic resonance imaging, but microstructural white matter abnormalities (diffuse axonal lesion) can be found in diffusion tensor imaging. Different brain networks work together to form an important part of the cognition process, and they can be affected by TBI. The default mode network (DMN) plays an important central role in normal brain activities, presenting greater relative deactivation during more cognitively demanding tasks. After deactivation, it allows a distinct network to activate. This network (the central executive network) acts mainly during tasks involving executive functions. The salience network is another network necessary for normal executive function, and its activation leads to deactivation of the DMN. The use of red or near-infrared (NIR) light to stimulate or regenerate tissue is known as photobiomodulation. It was discovered that NIR (wavelength 800–900 nm) and red (wavelength 600 nm) light-emitting diodes (LEDs) are able to penetrate through scalp and skull and have the potential to improve the subnormal, cellular activity of compromised brain tissue. Based on this, different experimental and clinical studies were done to test LED therapy for TBI, and promising results were found. It leads us to consider developing different approaches to maximize the positive effects of this therapy and improve the quality of life of TBI patients. Keywords: traumatic brain injuries, diffuse axonal injury, low-level light therapy, neurologic manifestations, post-concussion syndrome, quality of lifeSantos JGPaiva WSTeixeira MJDove Medical PressarticleBrain InjuriesTraumatic;Diffuse Axonal Injury;Low-Level Light Therapy;Neurologic Manifestations;Post-Concussion Syndrome;Quality of Life.Medical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol Volume 11, Pp 139-146 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Brain Injuries Traumatic;Diffuse Axonal Injury;Low-Level Light Therapy;Neurologic Manifestations;Post-Concussion Syndrome;Quality of Life. Medical technology R855-855.5
spellingShingle	Brain Injuries Traumatic;Diffuse Axonal Injury;Low-Level Light Therapy;Neurologic Manifestations;Post-Concussion Syndrome;Quality of Life. Medical technology R855-855.5 Santos JG Paiva WS Teixeira MJ Transcranial light-emitting diode therapy for neuropsychological improvement after traumatic brain injury: a new perspective for diffuse axonal lesion management
description	João Gustavo Rocha Peixoto dos Santos, Wellingson Silva Paiva, Manoel Jacobsen Teixeira Department of Neurological Surgery, University of São Paulo School of Medicine, São Paulo, Brazil Abstract: The cost of traumatic brain injury (TBI) for public health policies is undeniable today. Even patients who suffer from mild TBI may persist with cognitive symptoms weeks after the accident. Most of them show no lesion in computed tomography or conventional magnetic resonance imaging, but microstructural white matter abnormalities (diffuse axonal lesion) can be found in diffusion tensor imaging. Different brain networks work together to form an important part of the cognition process, and they can be affected by TBI. The default mode network (DMN) plays an important central role in normal brain activities, presenting greater relative deactivation during more cognitively demanding tasks. After deactivation, it allows a distinct network to activate. This network (the central executive network) acts mainly during tasks involving executive functions. The salience network is another network necessary for normal executive function, and its activation leads to deactivation of the DMN. The use of red or near-infrared (NIR) light to stimulate or regenerate tissue is known as photobiomodulation. It was discovered that NIR (wavelength 800–900 nm) and red (wavelength 600 nm) light-emitting diodes (LEDs) are able to penetrate through scalp and skull and have the potential to improve the subnormal, cellular activity of compromised brain tissue. Based on this, different experimental and clinical studies were done to test LED therapy for TBI, and promising results were found. It leads us to consider developing different approaches to maximize the positive effects of this therapy and improve the quality of life of TBI patients. Keywords: traumatic brain injuries, diffuse axonal injury, low-level light therapy, neurologic manifestations, post-concussion syndrome, quality of life
format	article
author	Santos JG Paiva WS Teixeira MJ
author_facet	Santos JG Paiva WS Teixeira MJ
author_sort	Santos JG
title	Transcranial light-emitting diode therapy for neuropsychological improvement after traumatic brain injury: a new perspective for diffuse axonal lesion management
title_short	Transcranial light-emitting diode therapy for neuropsychological improvement after traumatic brain injury: a new perspective for diffuse axonal lesion management
title_full	Transcranial light-emitting diode therapy for neuropsychological improvement after traumatic brain injury: a new perspective for diffuse axonal lesion management
title_fullStr	Transcranial light-emitting diode therapy for neuropsychological improvement after traumatic brain injury: a new perspective for diffuse axonal lesion management
title_full_unstemmed	Transcranial light-emitting diode therapy for neuropsychological improvement after traumatic brain injury: a new perspective for diffuse axonal lesion management
title_sort	transcranial light-emitting diode therapy for neuropsychological improvement after traumatic brain injury: a new perspective for diffuse axonal lesion management
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/7493898871924f6f8440aad7c0634d1b
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Transcranial light-emitting diode therapy for neuropsychological improvement after traumatic brain injury: a new perspective for diffuse axonal lesion management

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