Alzheimer's disease and primary open-angle glaucoma: is there a connection

Alzheimer's disease and primary open-angle glaucoma: is there a connection

Fani Tsolaki1, Eleni Gogaki1, Sotiria Tiganita1, Christina Skatharoudi1, Chrysanthi Lopatatzidi1, Fotios Topouzis2, Magdalini Tsolaki31Ophthalmology Department, Hippokrateion General Hospital, Thessaloniki, Greece; 2Ophthalmology Department, Aristotle University of Thessaloniki, Greece; 3Neurology D...

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Autores principales: Tsolaki F, Gogaki E, Tiganita S, Skatharoudi C, Lopatatzidi C, Topouzis F, Tsolaki M
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2011
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/749442ccd42b448eade3c57f471a986b
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spelling oai:doaj.org-article:749442ccd42b448eade3c57f471a986b2021-12-02T07:42:06ZAlzheimer's disease and primary open-angle glaucoma: is there a connection1177-54671177-5483https://doaj.org/article/749442ccd42b448eade3c57f471a986b2011-06-01T00:00:00Zhttp://www.dovepress.com/alzheimer39s-disease-and-primary-open-angle-glaucoma-is-there-a-connec-a7755https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Fani Tsolaki1, Eleni Gogaki1, Sotiria Tiganita1, Christina Skatharoudi1, Chrysanthi Lopatatzidi1, Fotios Topouzis2, Magdalini Tsolaki31Ophthalmology Department, Hippokrateion General Hospital, Thessaloniki, Greece; 2Ophthalmology Department, Aristotle University of Thessaloniki, Greece; 3Neurology Department, Aristotle University of Thessaloniki, GreeceAim: To present, through a thorough literature research, current and older scientific efforts to investigate the putative association between Alzheimer's disease (AD) and glaucoma, especially primary open-angle glaucoma (POAG).Methods: We included in our review article epidemiological, experimental and clinical laboratory studies.Results: While many authors support the existence of a strong correlation between the AD and POAG, based on epidemiological, genetic and immunohistochemical data, others present contradictory results, leaving the issue unresolved.Conclusion: Further research, probably targeted towards genetic parameters and based on large, multicenter studies has yet to be conducted. It is the authors' opinion however, that the existing data already justify the need for at least some degree of elevated clinical alertness for the occurrence of AD in patients with glaucoma and of glaucoma in patients with AD.Keywords: Alzheimer's disease, primary open-angle glaucoma, amyloid beta, apolipoprotein E, cerebrospinal fluid pressure, review article Tsolaki FGogaki ETiganita SSkatharoudi CLopatatzidi CTopouzis FTsolaki MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 887-890 (2011)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Tsolaki F
Gogaki E
Tiganita S
Skatharoudi C
Lopatatzidi C
Topouzis F
Tsolaki M
Alzheimer's disease and primary open-angle glaucoma: is there a connection
description Fani Tsolaki1, Eleni Gogaki1, Sotiria Tiganita1, Christina Skatharoudi1, Chrysanthi Lopatatzidi1, Fotios Topouzis2, Magdalini Tsolaki31Ophthalmology Department, Hippokrateion General Hospital, Thessaloniki, Greece; 2Ophthalmology Department, Aristotle University of Thessaloniki, Greece; 3Neurology Department, Aristotle University of Thessaloniki, GreeceAim: To present, through a thorough literature research, current and older scientific efforts to investigate the putative association between Alzheimer's disease (AD) and glaucoma, especially primary open-angle glaucoma (POAG).Methods: We included in our review article epidemiological, experimental and clinical laboratory studies.Results: While many authors support the existence of a strong correlation between the AD and POAG, based on epidemiological, genetic and immunohistochemical data, others present contradictory results, leaving the issue unresolved.Conclusion: Further research, probably targeted towards genetic parameters and based on large, multicenter studies has yet to be conducted. It is the authors' opinion however, that the existing data already justify the need for at least some degree of elevated clinical alertness for the occurrence of AD in patients with glaucoma and of glaucoma in patients with AD.Keywords: Alzheimer's disease, primary open-angle glaucoma, amyloid beta, apolipoprotein E, cerebrospinal fluid pressure, review article 
format article
author Tsolaki F
Gogaki E
Tiganita S
Skatharoudi C
Lopatatzidi C
Topouzis F
Tsolaki M
author_facet Tsolaki F
Gogaki E
Tiganita S
Skatharoudi C
Lopatatzidi C
Topouzis F
Tsolaki M
author_sort Tsolaki F
title Alzheimer's disease and primary open-angle glaucoma: is there a connection
title_short Alzheimer's disease and primary open-angle glaucoma: is there a connection
title_full Alzheimer's disease and primary open-angle glaucoma: is there a connection
title_fullStr Alzheimer's disease and primary open-angle glaucoma: is there a connection
title_full_unstemmed Alzheimer's disease and primary open-angle glaucoma: is there a connection
title_sort alzheimer's disease and primary open-angle glaucoma: is there a connection
publisher Dove Medical Press
publishDate 2011
url https://doaj.org/article/749442ccd42b448eade3c57f471a986b
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AT tiganitas alzheimeramp39sdiseaseandprimaryopenangleglaucomaisthereaconnection
AT skatharoudic alzheimeramp39sdiseaseandprimaryopenangleglaucomaisthereaconnection
AT lopatatzidic alzheimeramp39sdiseaseandprimaryopenangleglaucomaisthereaconnection
AT topouzisf alzheimeramp39sdiseaseandprimaryopenangleglaucomaisthereaconnection
AT tsolakim alzheimeramp39sdiseaseandprimaryopenangleglaucomaisthereaconnection
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