Management of chronic ocular sarcoidosis: challenges and solutions

Artemis Matsou,1 Konstantinos T Tsaousis2 1Second Department of Ophthalmology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Greece; 2Ophthalmology Department, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, UK Background: Sarcoidosis constitutes one...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Matsou A, Tsaousis KT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	ocular sarcoidosis uveitis immunosuppression biologic agents anti-TNFα Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/749445f97bae4dc2818b949fb2a7ce4c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:749445f97bae4dc2818b949fb2a7ce4c
record_format	dspace
spelling	oai:doaj.org-article:749445f97bae4dc2818b949fb2a7ce4c2021-12-02T02:08:02ZManagement of chronic ocular sarcoidosis: challenges and solutions1177-5483https://doaj.org/article/749445f97bae4dc2818b949fb2a7ce4c2018-03-01T00:00:00Zhttps://www.dovepress.com/management-of-chronic-ocular-sarcoidosis-challenges-and-solutions-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Artemis Matsou,1 Konstantinos T Tsaousis2 1Second Department of Ophthalmology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Greece; 2Ophthalmology Department, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, UK Background: Sarcoidosis constitutes one of the leading causes of ocular inflammation. Chronic ocular sarcoidosis can affect any segment of the eye and its adnexa, producing a wide range of clinical manifestations and severity. If left untreated, permanent visual impairment or even blindness may ensue. Treatment approaches vary from topical therapy to systemic agents that induce immunosuppression to different levels according to disease severity. Objective: To review the published literature on the management options for chronic ocular sarcoidosis and provide a comprehensive list of available treatment strategies, including the newer biologics. Summary: Ocular disease remains a challenging aspect of sarcoidosis and may even be the presenting sign of the disease. Prompt and effective therapy may reverse visual damage and prevent permanent loss of vision. Because of the complexity of the disease, a multidisciplinary approach is often required, with a view to addressing both the ocular and other systemic manifestations of sarcoidosis. Recent data suggest that achieving overall optimal systemic control is of paramount importance in controlling eye inflammation as well. Cytotoxic immunosuppressive agents for refractory chronic ocular disease, as well as biologic anti-TNFα therapies, have advanced the management of chronic disease and should be considered corticosteroid-sparing strategies before the onset of significant steroid-induced morbidity. Keywords: ocular sarcoidosis, uveitis, immunosuppression, biologic agents, anti-TNFαMatsou ATsaousis KTDove Medical Pressarticleocular sarcoidosisuveitisimmunosuppressionbiologic agentsanti-TNFαOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 519-532 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ocular sarcoidosis uveitis immunosuppression biologic agents anti-TNFα Ophthalmology RE1-994
spellingShingle	ocular sarcoidosis uveitis immunosuppression biologic agents anti-TNFα Ophthalmology RE1-994 Matsou A Tsaousis KT Management of chronic ocular sarcoidosis: challenges and solutions
description	Artemis Matsou,1 Konstantinos T Tsaousis2 1Second Department of Ophthalmology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Greece; 2Ophthalmology Department, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, UK Background: Sarcoidosis constitutes one of the leading causes of ocular inflammation. Chronic ocular sarcoidosis can affect any segment of the eye and its adnexa, producing a wide range of clinical manifestations and severity. If left untreated, permanent visual impairment or even blindness may ensue. Treatment approaches vary from topical therapy to systemic agents that induce immunosuppression to different levels according to disease severity. Objective: To review the published literature on the management options for chronic ocular sarcoidosis and provide a comprehensive list of available treatment strategies, including the newer biologics. Summary: Ocular disease remains a challenging aspect of sarcoidosis and may even be the presenting sign of the disease. Prompt and effective therapy may reverse visual damage and prevent permanent loss of vision. Because of the complexity of the disease, a multidisciplinary approach is often required, with a view to addressing both the ocular and other systemic manifestations of sarcoidosis. Recent data suggest that achieving overall optimal systemic control is of paramount importance in controlling eye inflammation as well. Cytotoxic immunosuppressive agents for refractory chronic ocular disease, as well as biologic anti-TNFα therapies, have advanced the management of chronic disease and should be considered corticosteroid-sparing strategies before the onset of significant steroid-induced morbidity. Keywords: ocular sarcoidosis, uveitis, immunosuppression, biologic agents, anti-TNFα
format	article
author	Matsou A Tsaousis KT
author_facet	Matsou A Tsaousis KT
author_sort	Matsou A
title	Management of chronic ocular sarcoidosis: challenges and solutions
title_short	Management of chronic ocular sarcoidosis: challenges and solutions
title_full	Management of chronic ocular sarcoidosis: challenges and solutions
title_fullStr	Management of chronic ocular sarcoidosis: challenges and solutions
title_full_unstemmed	Management of chronic ocular sarcoidosis: challenges and solutions
title_sort	management of chronic ocular sarcoidosis: challenges and solutions
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/749445f97bae4dc2818b949fb2a7ce4c
work_keys_str_mv	AT matsoua managementofchronicocularsarcoidosischallengesandsolutions AT tsaousiskt managementofchronicocularsarcoidosischallengesandsolutions
_version_	1718402655006490624

Management of chronic ocular sarcoidosis: challenges and solutions

Ejemplares similares