Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails

The intrinsic disorder of histone tails poses challenges in their characterization. Here the authors apply extensive molecular dynamics simulations of the full nucleosome to show reversible binding to DNA with specific binding modes of different types of histone tails, where charge-altering modifica...

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Autores principales:	Yunhui Peng, Shuxiang Li, Alexey Onufriev, David Landsman, Anna R. Panchenko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7499acb911de44ebb564828f5709af4e
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id	oai:doaj.org-article:7499acb911de44ebb564828f5709af4e
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spelling	oai:doaj.org-article:7499acb911de44ebb564828f5709af4e2021-12-02T17:41:19ZBinding of regulatory proteins to nucleosomes is modulated by dynamic histone tails10.1038/s41467-021-25568-62041-1723https://doaj.org/article/7499acb911de44ebb564828f5709af4e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25568-6https://doaj.org/toc/2041-1723The intrinsic disorder of histone tails poses challenges in their characterization. Here the authors apply extensive molecular dynamics simulations of the full nucleosome to show reversible binding to DNA with specific binding modes of different types of histone tails, where charge-altering modifications suppress tail-DNA interactions and may boost interactions between nucleosomes and nucleosome-binding proteins.Yunhui PengShuxiang LiAlexey OnufrievDavid LandsmanAnna R. PanchenkoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunhui Peng Shuxiang Li Alexey Onufriev David Landsman Anna R. Panchenko Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails
description	The intrinsic disorder of histone tails poses challenges in their characterization. Here the authors apply extensive molecular dynamics simulations of the full nucleosome to show reversible binding to DNA with specific binding modes of different types of histone tails, where charge-altering modifications suppress tail-DNA interactions and may boost interactions between nucleosomes and nucleosome-binding proteins.
format	article
author	Yunhui Peng Shuxiang Li Alexey Onufriev David Landsman Anna R. Panchenko
author_facet	Yunhui Peng Shuxiang Li Alexey Onufriev David Landsman Anna R. Panchenko
author_sort	Yunhui Peng
title	Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails
title_short	Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails
title_full	Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails
title_fullStr	Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails
title_full_unstemmed	Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails
title_sort	binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7499acb911de44ebb564828f5709af4e
work_keys_str_mv	AT yunhuipeng bindingofregulatoryproteinstonucleosomesismodulatedbydynamichistonetails AT shuxiangli bindingofregulatoryproteinstonucleosomesismodulatedbydynamichistonetails AT alexeyonufriev bindingofregulatoryproteinstonucleosomesismodulatedbydynamichistonetails AT davidlandsman bindingofregulatoryproteinstonucleosomesismodulatedbydynamichistonetails AT annarpanchenko bindingofregulatoryproteinstonucleosomesismodulatedbydynamichistonetails
_version_	1718379712476086272

Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails

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