Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.

<h4>Background</h4>Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD).<h4>Methods and findings</h4&g...

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Autores principales:	Zitta B Harboe, Reimar W Thomsen, Anders Riis, Palle Valentiner-Branth, Jens Jørgen Christensen, Lotte Lambertsen, Karen A Krogfelt, Helle B Konradsen, Thomas L Benfield
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/749a146ceb854e2b9037865444454544
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spelling	oai:doaj.org-article:749a146ceb854e2b90378654444545442021-11-25T05:37:38ZPneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.1549-12771549-167610.1371/journal.pmed.1000081https://doaj.org/article/749a146ceb854e2b90378654444545442009-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19468297/pdf/?tool=EBIhttps://doaj.org/toc/1549-1277https://doaj.org/toc/1549-1676<h4>Background</h4>Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD).<h4>Methods and findings</h4>In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio >or=3, p<0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality.<h4>Conclusions</h4>Specific pneumococcal serotypes strongly and independently affect IPD associated mortality.Zitta B HarboeReimar W ThomsenAnders RiisPalle Valentiner-BranthJens Jørgen ChristensenLotte LambertsenKaren A KrogfeltHelle B KonradsenThomas L BenfieldPublic Library of Science (PLoS)articleMedicineRENPLoS Medicine, Vol 6, Iss 5, p e1000081 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Zitta B Harboe Reimar W Thomsen Anders Riis Palle Valentiner-Branth Jens Jørgen Christensen Lotte Lambertsen Karen A Krogfelt Helle B Konradsen Thomas L Benfield Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.
description	<h4>Background</h4>Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD).<h4>Methods and findings</h4>In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio >or=3, p<0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality.<h4>Conclusions</h4>Specific pneumococcal serotypes strongly and independently affect IPD associated mortality.
format	article
author	Zitta B Harboe Reimar W Thomsen Anders Riis Palle Valentiner-Branth Jens Jørgen Christensen Lotte Lambertsen Karen A Krogfelt Helle B Konradsen Thomas L Benfield
author_facet	Zitta B Harboe Reimar W Thomsen Anders Riis Palle Valentiner-Branth Jens Jørgen Christensen Lotte Lambertsen Karen A Krogfelt Helle B Konradsen Thomas L Benfield
author_sort	Zitta B Harboe
title	Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.
title_short	Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.
title_full	Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.
title_fullStr	Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.
title_full_unstemmed	Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.
title_sort	pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/749a146ceb854e2b9037865444454544
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Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.

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