Impact of metabolic status on the incidence of psoriasis: a Korean nationwide cohort study

Abstract Growing evidence suggests that obesity is a risk factor for incident psoriasis. This study was aimed to evaluate the association of obesity and metabolic status with the incidence of psoriasis. A total of 418,057 adults were followed-up using a nationwide prospective cohort study in Korea....

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Autores principales:	Eun Sook Kim, Kyungdo Han, Mee Kyoung Kim, Yong-Moon Park, Ki-Hyun Baek, Sung Dae Moon, Je-Ho Han, Ki-Ho Song, Hyuk-Sang Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/749aac7281204e88ba558714f3c98066
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spelling	oai:doaj.org-article:749aac7281204e88ba558714f3c980662021-12-02T12:32:02ZImpact of metabolic status on the incidence of psoriasis: a Korean nationwide cohort study10.1038/s41598-017-01983-y2045-2322https://doaj.org/article/749aac7281204e88ba558714f3c980662017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01983-yhttps://doaj.org/toc/2045-2322Abstract Growing evidence suggests that obesity is a risk factor for incident psoriasis. This study was aimed to evaluate the association of obesity and metabolic status with the incidence of psoriasis. A total of 418,057 adults were followed-up using a nationwide prospective cohort study in Korea. Participants were stratified based on the body mass index categories and metabolic condition. During the follow-up visit, 11054 (2.6%) cases were found to have psoriasis. Diabetes, hypertension, hyperlipidemia, and obesity were all found to be risk factors for incident psoriasis. The metabolically unhealthy non-obese (MUNO) subjects (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.22–1.37) and metabolically unhealthy obese subjects (MUO; HR, 1.33; 95% CI, 1. 26–1.41) had a significantly higher risk of psoriasis incidence as compared to metabolically healthy non-obese subjects. The risk of psoriasis development was found to be high among the MUNO and MUO subjects in both sexes and all age groups. In conclusion, the metabolic health status was significantly associated with an increased risk of psoriasis in both obese and non-obese individuals. However, further studies are needed to evaluate whether the control of metabolic parameters can lower the incidence of psoriasis.Eun Sook KimKyungdo HanMee Kyoung KimYong-Moon ParkKi-Hyun BaekSung Dae MoonJe-Ho HanKi-Ho SongHyuk-Sang KwonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eun Sook Kim Kyungdo Han Mee Kyoung Kim Yong-Moon Park Ki-Hyun Baek Sung Dae Moon Je-Ho Han Ki-Ho Song Hyuk-Sang Kwon Impact of metabolic status on the incidence of psoriasis: a Korean nationwide cohort study
description	Abstract Growing evidence suggests that obesity is a risk factor for incident psoriasis. This study was aimed to evaluate the association of obesity and metabolic status with the incidence of psoriasis. A total of 418,057 adults were followed-up using a nationwide prospective cohort study in Korea. Participants were stratified based on the body mass index categories and metabolic condition. During the follow-up visit, 11054 (2.6%) cases were found to have psoriasis. Diabetes, hypertension, hyperlipidemia, and obesity were all found to be risk factors for incident psoriasis. The metabolically unhealthy non-obese (MUNO) subjects (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.22–1.37) and metabolically unhealthy obese subjects (MUO; HR, 1.33; 95% CI, 1. 26–1.41) had a significantly higher risk of psoriasis incidence as compared to metabolically healthy non-obese subjects. The risk of psoriasis development was found to be high among the MUNO and MUO subjects in both sexes and all age groups. In conclusion, the metabolic health status was significantly associated with an increased risk of psoriasis in both obese and non-obese individuals. However, further studies are needed to evaluate whether the control of metabolic parameters can lower the incidence of psoriasis.
format	article
author	Eun Sook Kim Kyungdo Han Mee Kyoung Kim Yong-Moon Park Ki-Hyun Baek Sung Dae Moon Je-Ho Han Ki-Ho Song Hyuk-Sang Kwon
author_facet	Eun Sook Kim Kyungdo Han Mee Kyoung Kim Yong-Moon Park Ki-Hyun Baek Sung Dae Moon Je-Ho Han Ki-Ho Song Hyuk-Sang Kwon
author_sort	Eun Sook Kim
title	Impact of metabolic status on the incidence of psoriasis: a Korean nationwide cohort study
title_short	Impact of metabolic status on the incidence of psoriasis: a Korean nationwide cohort study
title_full	Impact of metabolic status on the incidence of psoriasis: a Korean nationwide cohort study
title_fullStr	Impact of metabolic status on the incidence of psoriasis: a Korean nationwide cohort study
title_full_unstemmed	Impact of metabolic status on the incidence of psoriasis: a Korean nationwide cohort study
title_sort	impact of metabolic status on the incidence of psoriasis: a korean nationwide cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/749aac7281204e88ba558714f3c98066
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Impact of metabolic status on the incidence of psoriasis: a Korean nationwide cohort study

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