Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion

Purpose Silent information regulator 1 (SIRT1) in the brain is essential for maintaining cellular homeostasis and plays a neuroprotective role in cerebral ischemia and neurodegenerative disorders. The effect of preischemic treadmill exercise on chronic cerebral hypoperfusion (CCH)-induced spatial le...

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Autores principales:	Jae-Min Lee, Jongmin Park, Joo-Hee Lee, Min Kyung Song, Youn-Jung Kim
Formato:	article
Lenguaje:	EN
Publicado:	Korean Continence Society 2021
Materias:	chronic cerebral hypoperfusion bilateral common carotid artery occlusion preischemic treadmill exercise silent information regulator 1 Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/74a2becb118e404ab47012a92a0748ae
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spelling	oai:doaj.org-article:74a2becb118e404ab47012a92a0748ae2021-11-30T04:10:47ZPreischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion2093-47772093-693110.5213/inj.2142340.170https://doaj.org/article/74a2becb118e404ab47012a92a0748ae2021-11-01T00:00:00Zhttp://www.einj.org/upload/pdf/inj-2142340-170.pdfhttps://doaj.org/toc/2093-4777https://doaj.org/toc/2093-6931Purpose Silent information regulator 1 (SIRT1) in the brain is essential for maintaining cellular homeostasis and plays a neuroprotective role in cerebral ischemia and neurodegenerative disorders. The effect of preischemic treadmill exercise on chronic cerebral hypoperfusion (CCH)-induced spatial learning memory impairment, microvascular injury, and blood-brain barrier (BBB) disruption in relation with SIRT1 expression was evaluated. Methods Prior to bilateral common carotid artery occlusion (BCCAO) surgery, the rats in the exercise groups performed low-intensity treadmill running for 30 minutes once daily during 8 weeks. BCCAO surgery was performed on male Wistar rats at 12 weeks of age. Spatial learning memory was measured using the Morris water maze test. Neuronal nuclear antigen, SIRT1, and rat endothelial cells antigen 1 were determined by immunohistochemistry and platelet-derived growth factor receptor beta was determined by immunofluorescence. Results Preischemic treadmill exercise ameliorated spatial learning memory impairment and enhanced SIRT1 expression in the BCCAO rats. Preischemic treadmill exercise ameliorated BCCAO-induced damage to microvasculature and pericytes that make up the BBB. The effect of preischemic treadmill exercise was lost with sirtinol treatment. Conclusions These results can apply treadmill exercise prior to cerebral ischemia as a rational preventive and therapeutic intervention strategy to improve cognitive dysfunction in CCH patients.Jae-Min LeeJongmin ParkJoo-Hee LeeMin Kyung SongYoun-Jung KimKorean Continence Societyarticlechronic cerebral hypoperfusionbilateral common carotid artery occlusionpreischemic treadmill exercisesilent information regulator 1Diseases of the genitourinary system. UrologyRC870-923ENInternational Neurourology Journal, Vol 25, Iss Suppl 2, Pp S72-80 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic cerebral hypoperfusion bilateral common carotid artery occlusion preischemic treadmill exercise silent information regulator 1 Diseases of the genitourinary system. Urology RC870-923
spellingShingle	chronic cerebral hypoperfusion bilateral common carotid artery occlusion preischemic treadmill exercise silent information regulator 1 Diseases of the genitourinary system. Urology RC870-923 Jae-Min Lee Jongmin Park Joo-Hee Lee Min Kyung Song Youn-Jung Kim Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion
description	Purpose Silent information regulator 1 (SIRT1) in the brain is essential for maintaining cellular homeostasis and plays a neuroprotective role in cerebral ischemia and neurodegenerative disorders. The effect of preischemic treadmill exercise on chronic cerebral hypoperfusion (CCH)-induced spatial learning memory impairment, microvascular injury, and blood-brain barrier (BBB) disruption in relation with SIRT1 expression was evaluated. Methods Prior to bilateral common carotid artery occlusion (BCCAO) surgery, the rats in the exercise groups performed low-intensity treadmill running for 30 minutes once daily during 8 weeks. BCCAO surgery was performed on male Wistar rats at 12 weeks of age. Spatial learning memory was measured using the Morris water maze test. Neuronal nuclear antigen, SIRT1, and rat endothelial cells antigen 1 were determined by immunohistochemistry and platelet-derived growth factor receptor beta was determined by immunofluorescence. Results Preischemic treadmill exercise ameliorated spatial learning memory impairment and enhanced SIRT1 expression in the BCCAO rats. Preischemic treadmill exercise ameliorated BCCAO-induced damage to microvasculature and pericytes that make up the BBB. The effect of preischemic treadmill exercise was lost with sirtinol treatment. Conclusions These results can apply treadmill exercise prior to cerebral ischemia as a rational preventive and therapeutic intervention strategy to improve cognitive dysfunction in CCH patients.
format	article
author	Jae-Min Lee Jongmin Park Joo-Hee Lee Min Kyung Song Youn-Jung Kim
author_facet	Jae-Min Lee Jongmin Park Joo-Hee Lee Min Kyung Song Youn-Jung Kim
author_sort	Jae-Min Lee
title	Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion
title_short	Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion
title_full	Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion
title_fullStr	Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion
title_full_unstemmed	Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion
title_sort	preischemic treadmill exercise ameliorates memory impairment and microvasculature damage in rat model of chronic cerebral hypoperfusion
publisher	Korean Continence Society
publishDate	2021
url	https://doaj.org/article/74a2becb118e404ab47012a92a0748ae
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Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion

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