Sjögren's syndrome and systemic lupus erythematosus: links and risks

Sjögren's syndrome and systemic lupus erythematosus: links and risks

Sandra Gofinet Pasoto,1,2 Victor Adriano de Oliveira Martins,1 Eloisa Bonfa1 1Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil; 2Laboratory Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paul...

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Autores principales: Pasoto SG, Adriano de Oliveira Martins V, Bonfa E
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Systemic lupus erythematosus
primary Sjögren’s syndrome
secondary Sjögren’s syndrome
polyautoimmunity
anti-Ro
anti-SSA
Diseases of the musculoskeletal system
RC925-935
Acceso en línea:https://doaj.org/article/74a305aa357c4af9899dadf47340b660
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spelling oai:doaj.org-article:74a305aa357c4af9899dadf47340b6602021-12-02T02:37:23ZSjögren's syndrome and systemic lupus erythematosus: links and risks1179-156Xhttps://doaj.org/article/74a305aa357c4af9899dadf47340b6602019-01-01T00:00:00Zhttps://www.dovepress.com/sjogrens-syndrome-and-systemic-lupus-erythematosus-links-and-risks-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XSandra Gofinet Pasoto,1,2 Victor Adriano de Oliveira Martins,1 Eloisa Bonfa1 1Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil; 2Laboratory Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Sao Paulo, Brazil Abstract: Systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) may coexist, and they are chronic complex disorders, with an autoimmune background, multifactorial etiology, multiple circulating autoantibodies, and variable prognosis. The prominent feature of SS is the impairment of the lacrimal and salivary glands leading to sicca symptoms. This disease may be classified as primary Sjögren’s syndrome (pSS), or secondary Sjögren’s syndrome (sSS) since it is often associated to other autoimmune disorders, principally SLE, rheumatoid arthritis, and systemic sclerosis. Systematic reviews and meta-analyses show an sSS prevalence in SLE patients of about 14%–17.8%. Herein, we updated important aspects of the clinical association between SLE and sSS through a narrative review of the PubMed database in the last 5 years (from July 2013 to October 2018) with the terms “Sjogren syndrome and systemic lupus erythematosus”. The following aspects are addressed: the classification criteria for sSS; differences and similarities between SLE and pSS regarding demographic, clinical, and serological characteristics (including new autoantibodies), as well as comorbidities; the etiopathogenic links between SLE and pSS (including genetic and environmental factors, B-cell activation, and autoantibodies); the predictive factors for sSS onset in SLE patients; the ocular and oral involvements due to sSS in SLE; and the main distinctive demographic, clinical, and serological features of SLE with and without associated SS. Keywords: systemic lupus erythematosus, primary Sjögren’s syndrome, secondary Sjögren’s syndrome, polyautoimmunity, anti-Ro, anti-SSA, autoantibodies, pathogenesisPasoto SGAdriano de Oliveira Martins VBonfa EDove Medical PressarticleSystemic lupus erythematosusprimary Sjögren’s syndromesecondary Sjögren’s syndromepolyautoimmunityanti-Roanti-SSADiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 11, Pp 33-45 (2019)
institution DOAJ
collection DOAJ
language EN
topic Systemic lupus erythematosus
primary Sjögren’s syndrome
secondary Sjögren’s syndrome
polyautoimmunity
anti-Ro
anti-SSA
Diseases of the musculoskeletal system
RC925-935
spellingShingle Systemic lupus erythematosus
primary Sjögren’s syndrome
secondary Sjögren’s syndrome
polyautoimmunity
anti-Ro
anti-SSA
Diseases of the musculoskeletal system
RC925-935
Pasoto SG
Adriano de Oliveira Martins V
Bonfa E
Sjögren's syndrome and systemic lupus erythematosus: links and risks
description Sandra Gofinet Pasoto,1,2 Victor Adriano de Oliveira Martins,1 Eloisa Bonfa1 1Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil; 2Laboratory Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Sao Paulo, Brazil Abstract: Systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) may coexist, and they are chronic complex disorders, with an autoimmune background, multifactorial etiology, multiple circulating autoantibodies, and variable prognosis. The prominent feature of SS is the impairment of the lacrimal and salivary glands leading to sicca symptoms. This disease may be classified as primary Sjögren’s syndrome (pSS), or secondary Sjögren’s syndrome (sSS) since it is often associated to other autoimmune disorders, principally SLE, rheumatoid arthritis, and systemic sclerosis. Systematic reviews and meta-analyses show an sSS prevalence in SLE patients of about 14%–17.8%. Herein, we updated important aspects of the clinical association between SLE and sSS through a narrative review of the PubMed database in the last 5 years (from July 2013 to October 2018) with the terms “Sjogren syndrome and systemic lupus erythematosus”. The following aspects are addressed: the classification criteria for sSS; differences and similarities between SLE and pSS regarding demographic, clinical, and serological characteristics (including new autoantibodies), as well as comorbidities; the etiopathogenic links between SLE and pSS (including genetic and environmental factors, B-cell activation, and autoantibodies); the predictive factors for sSS onset in SLE patients; the ocular and oral involvements due to sSS in SLE; and the main distinctive demographic, clinical, and serological features of SLE with and without associated SS. Keywords: systemic lupus erythematosus, primary Sjögren’s syndrome, secondary Sjögren’s syndrome, polyautoimmunity, anti-Ro, anti-SSA, autoantibodies, pathogenesis
format article
author Pasoto SG
Adriano de Oliveira Martins V
Bonfa E
author_facet Pasoto SG
Adriano de Oliveira Martins V
Bonfa E
author_sort Pasoto SG
title Sjögren's syndrome and systemic lupus erythematosus: links and risks
title_short Sjögren's syndrome and systemic lupus erythematosus: links and risks
title_full Sjögren's syndrome and systemic lupus erythematosus: links and risks
title_fullStr Sjögren's syndrome and systemic lupus erythematosus: links and risks
title_full_unstemmed Sjögren's syndrome and systemic lupus erythematosus: links and risks
title_sort sjögren's syndrome and systemic lupus erythematosus: links and risks
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/74a305aa357c4af9899dadf47340b660
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AT bonfae sjoumlgren39ssyndromeandsystemiclupuserythematosuslinksandrisks
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