Hypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy

Introduction Highly active antiretroviral therapy (HAART) and HIV/AIDS have been demonstrated to induce endocrine/metabolic dysfunction with a consequential increase in morbidity/mortality due to organ toxicities. This study aimed at investigating the possible protective effect of Hypoxis hemerocall...

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Autores principales:	Ismail Olasile Onanuga, Ayoola Isaac Jegede, Ugochukwu Offor, Oluwatosin O. Ogedengbe, Edwin C.S. Naidu, Anetkan I. Peter, Onyemaechi Okpara Azu
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	lipids antiretroviral therapy hypoxis hemerocallidea hepatic dysfunction metabolic disorder Medicine R
Acceso en línea:	https://doaj.org/article/74a49f3a971b447bbde22b06a83845e7
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spelling	oai:doaj.org-article:74a49f3a971b447bbde22b06a83845e72021-12-02T18:39:22ZHypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy1734-19221896-915110.5114/aoms.2018.75220https://doaj.org/article/74a49f3a971b447bbde22b06a83845e72019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Hypoxis-hemerocallidea-alters-metabolic-parameters-and-hepatic-histomorphology-in,75475,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Highly active antiretroviral therapy (HAART) and HIV/AIDS have been demonstrated to induce endocrine/metabolic dysfunction with a consequential increase in morbidity/mortality due to organ toxicities. This study aimed at investigating the possible protective effect of Hypoxis hemerocallidea (HH) against metabolic and hepatic histomorphology of diabetic rats under HAART. Material and methods Sixty-two adult male Sprague-Dawley rats were divided into a normoglycemic group A (n = 6) and 7 diabetic (110 mg/kg nicotinamide + 45 mg/kg streptozotocin) groups (B–H) (n = 8) and treated according to protocols. Concomitant treatment with adjuvant HH and HAART resulted in the least %body weight gain as the liver weight decreased in all treated animals. Results Significant changes in serum lipids were aggravated by treatment with HH and HAART, triglycerides and total cholesterol levels were elevated (p < 0.001/0.05), but changes in high-density lipoprotein (HDL) and total protein levels were insignificant. While artherosclerotic and cardiopulmonary indexes remained insignificant, concomitant use of HH with HAART in diabetes resulted in reduction of low-density lipoprotein (LDL) (p < 0.001), and increased triglyceride (p < 0.05) and total cholesterol (p < 0.001). The parameters of liver injury showed a significant (p < 0.05) increase in ALT of animals treated with HH alone, HAART + HH and melatonin; however, an insignificant decline in AST level was recorded. Treatment with adjuvant HAART, HH and melatonin resulted in significant (p < 0.005/0.0001) up-regulation of ALP and total bilirubin levels. Histopathology derangement ranged from severe hepatocellular distortions, necrosis with reduced glycogen expression following co-treatment of HAART+melatonin, HH and HAART alone in diabetes. Conclusions Presumptive hypoglycemic use of HH with HAART by people living with HIV/AIDS requires caution as implications for hepatocellular injuries are suspected with further uncontrolled metabolic disorder.Ismail Olasile OnanugaAyoola Isaac JegedeUgochukwu OfforOluwatosin O. OgedengbeEdwin C.S. NaiduAnetkan I. PeterOnyemaechi Okpara AzuTermedia Publishing Housearticlelipidsantiretroviral therapyhypoxis hemerocallideahepatic dysfunctionmetabolic disorderMedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 212-224 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	lipids antiretroviral therapy hypoxis hemerocallidea hepatic dysfunction metabolic disorder Medicine R
spellingShingle	lipids antiretroviral therapy hypoxis hemerocallidea hepatic dysfunction metabolic disorder Medicine R Ismail Olasile Onanuga Ayoola Isaac Jegede Ugochukwu Offor Oluwatosin O. Ogedengbe Edwin C.S. Naidu Anetkan I. Peter Onyemaechi Okpara Azu Hypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy
description	Introduction Highly active antiretroviral therapy (HAART) and HIV/AIDS have been demonstrated to induce endocrine/metabolic dysfunction with a consequential increase in morbidity/mortality due to organ toxicities. This study aimed at investigating the possible protective effect of Hypoxis hemerocallidea (HH) against metabolic and hepatic histomorphology of diabetic rats under HAART. Material and methods Sixty-two adult male Sprague-Dawley rats were divided into a normoglycemic group A (n = 6) and 7 diabetic (110 mg/kg nicotinamide + 45 mg/kg streptozotocin) groups (B–H) (n = 8) and treated according to protocols. Concomitant treatment with adjuvant HH and HAART resulted in the least %body weight gain as the liver weight decreased in all treated animals. Results Significant changes in serum lipids were aggravated by treatment with HH and HAART, triglycerides and total cholesterol levels were elevated (p < 0.001/0.05), but changes in high-density lipoprotein (HDL) and total protein levels were insignificant. While artherosclerotic and cardiopulmonary indexes remained insignificant, concomitant use of HH with HAART in diabetes resulted in reduction of low-density lipoprotein (LDL) (p < 0.001), and increased triglyceride (p < 0.05) and total cholesterol (p < 0.001). The parameters of liver injury showed a significant (p < 0.05) increase in ALT of animals treated with HH alone, HAART + HH and melatonin; however, an insignificant decline in AST level was recorded. Treatment with adjuvant HAART, HH and melatonin resulted in significant (p < 0.005/0.0001) up-regulation of ALP and total bilirubin levels. Histopathology derangement ranged from severe hepatocellular distortions, necrosis with reduced glycogen expression following co-treatment of HAART+melatonin, HH and HAART alone in diabetes. Conclusions Presumptive hypoglycemic use of HH with HAART by people living with HIV/AIDS requires caution as implications for hepatocellular injuries are suspected with further uncontrolled metabolic disorder.
format	article
author	Ismail Olasile Onanuga Ayoola Isaac Jegede Ugochukwu Offor Oluwatosin O. Ogedengbe Edwin C.S. Naidu Anetkan I. Peter Onyemaechi Okpara Azu
author_facet	Ismail Olasile Onanuga Ayoola Isaac Jegede Ugochukwu Offor Oluwatosin O. Ogedengbe Edwin C.S. Naidu Anetkan I. Peter Onyemaechi Okpara Azu
author_sort	Ismail Olasile Onanuga
title	Hypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy
title_short	Hypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy
title_full	Hypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy
title_fullStr	Hypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy
title_full_unstemmed	Hypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy
title_sort	hypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/74a49f3a971b447bbde22b06a83845e7
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Hypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy

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