COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL FAILURE AND HEMODIALYTIC PATIENTS

BACKGROUND AND OBJECTIVE: Various abnormalities of the immune system have been demonstrated in patients on hemodialysis. Imbalances in Th1 and Th2 responses have an important role in these complications. These cells produce predominantly some cytokine profiles and also express preferentially co-stim...

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Autores principales: AR Rafiei, A Makhlough, S Hashemi Nasab, MR Mahdavi, AM Mirabi
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Publicado: Babol University of Medical Sciences 2008
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spelling oai:doaj.org-article:74a673184ae8474b8934105dafbd574e2021-11-10T09:07:19ZCOMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL FAILURE AND HEMODIALYTIC PATIENTS1561-41072251-7170https://doaj.org/article/74a673184ae8474b8934105dafbd574e2008-04-01T00:00:00Zhttp://jbums.org/article-1-2479-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Various abnormalities of the immune system have been demonstrated in patients on hemodialysis. Imbalances in Th1 and Th2 responses have an important role in these complications. These cells produce predominantly some cytokine profiles and also express preferentially co-stimulatory CD26 and CD30 molecules. The aim of the present study was to determine the levels of soluble CD26 and CD30 co-stimulatory molecules in sera of chronic renal failure (CRF) and hemodialytic patients (HD). METHODS: This case-control study was performed on 60 CRF patients (30 patients with CRF and 30 end-stage renal diseases under hemodialysis) and 60 healthy individuals. Renal function was evaluated by measuring serum levels of creatinine, albumin and urea. The serum levels of soluble CD26 and CD30 were determined by a sandwich enzyme-linked immunosorbent assay. FINDINGS: The serum levels of CD26 in the HD, CRF patients, and healthy controls were 275.4±125.6, 402.9± 103.1, and 389.2±117 ng/ml, respectively. The levels of CD26 was significantly decreased in the HD group compared to the CRF and control groups (p=0.002). On the other hand, the serum levels of CD30 in the HD, CRF patients, and healthy controls were 45.3±13.7, 38.9±14.5, 20.7±10.5 U/ml, respectively. The CD30 levels were significantly higher in HD and CRF patients than controls (p<0.0001). There was no significant difference between HD and CRF groups (p=0.05). CONCLUSION: High serum levels of CD30 in line with low expression of CD26 indicate a Th2 polarization in immune responses of HD patients. It is possible that this Th2- dominated immune response may contribute to the abnormality of the immune system in HD patients.AR Rafiei,A MakhloughS Hashemi NasabMR MahdaviAM MirabiBabol University of Medical Sciencesarticlechronic renal failureheamodialysiscd26cd30MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 10, Iss 1, Pp 20-27 (2008)
institution DOAJ
collection DOAJ
language EN
FA
topic chronic renal failure
heamodialysis
cd26
cd30
Medicine
R
Medicine (General)
R5-920
spellingShingle chronic renal failure
heamodialysis
cd26
cd30
Medicine
R
Medicine (General)
R5-920
AR Rafiei,
A Makhlough
S Hashemi Nasab
MR Mahdavi
AM Mirabi
COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL FAILURE AND HEMODIALYTIC PATIENTS
description BACKGROUND AND OBJECTIVE: Various abnormalities of the immune system have been demonstrated in patients on hemodialysis. Imbalances in Th1 and Th2 responses have an important role in these complications. These cells produce predominantly some cytokine profiles and also express preferentially co-stimulatory CD26 and CD30 molecules. The aim of the present study was to determine the levels of soluble CD26 and CD30 co-stimulatory molecules in sera of chronic renal failure (CRF) and hemodialytic patients (HD). METHODS: This case-control study was performed on 60 CRF patients (30 patients with CRF and 30 end-stage renal diseases under hemodialysis) and 60 healthy individuals. Renal function was evaluated by measuring serum levels of creatinine, albumin and urea. The serum levels of soluble CD26 and CD30 were determined by a sandwich enzyme-linked immunosorbent assay. FINDINGS: The serum levels of CD26 in the HD, CRF patients, and healthy controls were 275.4±125.6, 402.9± 103.1, and 389.2±117 ng/ml, respectively. The levels of CD26 was significantly decreased in the HD group compared to the CRF and control groups (p=0.002). On the other hand, the serum levels of CD30 in the HD, CRF patients, and healthy controls were 45.3±13.7, 38.9±14.5, 20.7±10.5 U/ml, respectively. The CD30 levels were significantly higher in HD and CRF patients than controls (p<0.0001). There was no significant difference between HD and CRF groups (p=0.05). CONCLUSION: High serum levels of CD30 in line with low expression of CD26 indicate a Th2 polarization in immune responses of HD patients. It is possible that this Th2- dominated immune response may contribute to the abnormality of the immune system in HD patients.
format article
author AR Rafiei,
A Makhlough
S Hashemi Nasab
MR Mahdavi
AM Mirabi
author_facet AR Rafiei,
A Makhlough
S Hashemi Nasab
MR Mahdavi
AM Mirabi
author_sort AR Rafiei,
title COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL FAILURE AND HEMODIALYTIC PATIENTS
title_short COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL FAILURE AND HEMODIALYTIC PATIENTS
title_full COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL FAILURE AND HEMODIALYTIC PATIENTS
title_fullStr COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL FAILURE AND HEMODIALYTIC PATIENTS
title_full_unstemmed COMPARISON OF SERUM LEVELS OF CD26 AND CD30 IN CHRONIC RENAL FAILURE AND HEMODIALYTIC PATIENTS
title_sort comparison of serum levels of cd26 and cd30 in chronic renal failure and hemodialytic patients
publisher Babol University of Medical Sciences
publishDate 2008
url https://doaj.org/article/74a673184ae8474b8934105dafbd574e
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AT amakhlough comparisonofserumlevelsofcd26andcd30inchronicrenalfailureandhemodialyticpatients
AT shasheminasab comparisonofserumlevelsofcd26andcd30inchronicrenalfailureandhemodialyticpatients
AT mrmahdavi comparisonofserumlevelsofcd26andcd30inchronicrenalfailureandhemodialyticpatients
AT ammirabi comparisonofserumlevelsofcd26andcd30inchronicrenalfailureandhemodialyticpatients
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